elacridar and ko 143
elacridar has been researched along with ko 143 in 8 studies
Compound Research Comparison
| Studies (elacridar) | Trials (elacridar) | Recent Studies (post-2010) (elacridar) | Studies (ko 143) | Trials (ko 143) | Recent Studies (post-2010) (ko 143) |
|---|---|---|---|---|---|
| 284 | 8 | 119 | 51 | 0 | 42 |
Protein Interaction Comparison
| Protein | Taxonomy | elacridar (IC50) | ko 143 (IC50) |
|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 0.271 | |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | 4.325 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.1882 |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Bernhardt, G; Buschauer, A; Egger, M; Fricker, G; König, B; Kühnle, M; Mahringer, A; Müller, C | 1 |
| Müller, H; Pick, A; Wiese, M | 1 |
| Black, C; Caputo, R; Gan, LS; Hetu, G; Rohde, E; Sands, E; Wang, J; Xiao, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Adler, P; Falson, P; Gimenez, AS; Gros, G; Hasserodt, J; Martinez, L; Maurin, P; Wolkowicz, R | 1 |
| Bauer, S; Bernhardt, G; Buschauer, A; König, B; Kühnle, M; Ochoa-Puentes, C | 1 |
| Baubichon-Cortay, H; Falson, P; Ferreira, MU; Khonkarn, R; Madeira Girio, P; Moreno, A; Mulhovo, S; Paterna, A | 1 |
Other Studies
8 other study(ies) available for elacridar and ko 143
| Article | Year |
|---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Multiple; Female; Humans; Inhibitory Concentration 50; Multidrug Resistance-Associated Protein 2; Neoplasm Proteins; Quinolines; Structure-Activity Relationship | 2009 |
Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line, Tumor; Chlorophyll; Humans; Molecular Conformation; Neoplasm Proteins; Phenylurea Compounds; Small Molecule Libraries | 2010 |
Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Dantrolene; Digoxin; Dose-Response Relationship, Drug; Humans; Mice; Mice, Knockout; Pharmaceutical Preparations; Time Factors; Tissue Distribution | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell Survival; HEK293 Cells; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Mice; Neoplasm Proteins; NIH 3T3 Cells; Urea | 2013 |
Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators.
Topics: | 2013 |
Monoterpene indole alkaloid azine derivatives as MDR reversal agents.
Topics: Alkaloids; Animals; Cell Line; Cell Proliferation; Cell Survival; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HEK293 Cells; Humans; Hydrazines; Indoles; Mice; Molecular Structure; NIH 3T3 Cells; Structure-Activity Relationship | 2018 |