cyc 202 has been researched along with u 0126 in 20 studies
| Studies (cyc 202) | Trials (cyc 202) | Recent Studies (post-2010) (cyc 202) | Studies (u 0126) | Trials (u 0126) | Recent Studies (post-2010) (u 0126) |
|---|---|---|---|---|---|
| 979 | 7 | 393 | 2,816 | 2 | 1,213 |
| Protein | Taxonomy | cyc 202 (IC50) | u 0126 (IC50) |
|---|---|---|---|
| RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens (human) | 0.29 | |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | 0.25 | |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 0.07 | |
| Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens (human) | 0.2816 | |
| Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (human) | 0.2529 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Bharate, SB; Raghuvanshi, R | 1 |
| Caballero, E; García-Cárceles, J; Gil, C; Martínez, A | 1 |
| Levasseur, M; McDougall, A | 1 |
| Lane, MD; Otto, TC; Tang, QQ | 1 |
| Groigno, L; Harrison, PK; Larman, MG; Leckie, CP; Philipova, R; Whitaker, M | 1 |
| Arlot-Bonnemains, Y; Dalbiès-Tran, R; Dupont, J; Mermillod, P; Papillier, P; Pennetier, S; Perreau, C; Prigent, C; Thélie, A; Uzbekov, R; Uzbekova, S | 1 |
| Beamish, H; De Boer, L; Desouza, C; Gabrielli, B; Giles, N; Oakes, V; Somodevilla-Torres, M; Stevens, F | 1 |
| Kabashima, K; Matsuzaki, M; Suzuki, H | 1 |
| Cui, XS; Kim, NH; Li, YH; Park, WJ; Sun, SC; Xu, YN; Zhang, DX | 1 |
| Flemr, M; Ma, J; Schultz, RM; Strnad, H; Svoboda, P | 1 |
| Shao, H; Xue, Q; Yu, B; Zhang, H; Zhang, X | 1 |
| Fujiwara, K; Hirose, M; Ito, J; Kamoshita, M; Kashiwazaki, N; Kato, T; Parys, JB; Sathanawongs, A; Wojcikiewicz, RJ | 1 |
| Beckstrom, B; Mendoza, C; Stanislawski, E; Stricker, SA; Wodajo, T | 1 |
| Cai, L; Guo, G; Liu, J; Wu, H; Xu, Y; Yang, J; Zhang, X; Zhao, Y | 1 |
| Goto, T; Kanda, K; Nishikata, T | 1 |
| Chen, J; Chen, Y; Li, L; Xie, Y; Zhong, Y | 1 |
1 review(s) available for cyc 202 and u 0126
| Article | Year |
|---|---|
Kinase Inhibitors as Underexplored Antiviral Agents.
Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses | 2022 |
19 other study(ies) available for cyc 202 and u 0126
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases | 2022 |
Sperm-induced calcium oscillations at fertilisation in ascidians are controlled by cyclin B1-dependent kinase activity.
Topics: Animals; Butadienes; Calcium; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Kinetics; Male; Microinjections; Nitriles; Oocytes; Oscillometry; Protein Biosynthesis; Protein Kinases; Purines; Recombinant Fusion Proteins; RNA, Messenger; Roscovitine; Sperm-Ovum Interactions; Spermatozoa; Urochordata | 2000 |
Mitotic clonal expansion: a synchronous process required for adipogenesis.
Topics: 3T3 Cells; Adipocytes; Animals; Butadienes; Cell Cycle; Cell Differentiation; Cell Nucleus; Enzyme Inhibitors; Kinetics; MAP Kinase Kinase Kinase 1; Mice; Mitosis; Nitriles; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purines; Roscovitine; Time Factors | 2003 |
Inhibiting MAP kinase activity prevents calcium transients and mitosis entry in early sea urchin embryos.
Topics: Animals; Blotting, Western; Butadienes; Calcium; CDC2 Protein Kinase; Cell Nucleus; Chromatin; Chromosomes; Cyclin B; Dextrans; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Fertilization; Immunoprecipitation; Lytechinus; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Phosphatases; Mitosis; Nitriles; Protein Tyrosine Phosphatases; Purines; Recombinant Fusion Proteins; Roscovitine; Time Factors; Xenopus Proteins | 2005 |
Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation.
Topics: Animals; Aurora Kinase A; Aurora Kinase B; Aurora Kinase C; Aurora Kinases; Butadienes; Cattle; CDC2 Protein Kinase; Cyclin B; Cyclin B1; Cytoplasm; Embryo, Mammalian; Female; Fertilization; Meiosis; Metformin; mRNA Cleavage and Polyadenylation Factors; Nitriles; Oocytes; Piperazines; Polyadenylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-mos; Purines; RNA, Messenger; Roscovitine | 2008 |
Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.
Topics: Butadienes; Cell Line; Cell Nucleus; Centrosome; Cyclin A; Cyclin-Dependent Kinase 2; Enzyme Inhibitors; G1 Phase; HeLa Cells; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitosis; Nitriles; Purines; RNA, Small Interfering; Roscovitine | 2008 |
Intermediate filament keratin dynamics during oocyte maturation requires maturation/M-phase promoting factor and mitogen-activated protein kinase kinase activities in the hamster.
Topics: Animals; Butadienes; Cricetinae; Enzyme Inhibitors; Female; Keratins; Maturation-Promoting Factor; Meiosis; Mesocricetus; Mitogen-Activated Protein Kinase Kinases; Nitriles; Oocytes; Purines; Roscovitine | 2010 |
Regulation of maternal gene expression by MEK/MAPK and MPF signaling in porcine oocytes during in vitro meiotic maturation.
Topics: Animals; Bone Morphogenetic Protein 15; Butadienes; CDC2 Protein Kinase; Cumulus Cells; Cyclin B1; Female; Gene Expression Regulation, Developmental; Growth Differentiation Factor 9; MAP Kinase Signaling System; Maturation-Promoting Factor; Mitosis; Mitosis Modulators; Nitriles; Oocytes; Oogenesis; Polyadenylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-mos; Purines; RNA, Messenger; Roscovitine; Sus scrofa | 2011 |
Maternally recruited DCP1A and DCP2 contribute to messenger RNA degradation during oocyte maturation and genome activation in mouse.
Topics: Animals; Butadienes; Endoribonucleases; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Mice; Nitriles; Oocytes; Protein Kinase Inhibitors; Purines; RNA Stability; RNA, Messenger; Roscovitine; Trans-Activators | 2013 |
ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity.
Topics: Animals; Butadienes; Cyclin-Dependent Kinase 5; Enzyme Activation; Fixatives; Formaldehyde; Hyperalgesia; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Neurons; Nitriles; Pain; Phosphorylation; Protein Kinase Inhibitors; Purines; Rats; Rats, Sprague-Dawley; Roscovitine | 2014 |
The effect of M-phase stage-dependent kinase inhibitors on inositol 1,4,5-trisphosphate receptor 1 (IP3 R1) expression and localization in pig oocytes.
Topics: Animals; Butadienes; Calcium; Cell Cycle Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; Inositol 1,4,5-Trisphosphate Receptors; Mice; Nitriles; Oocytes; Phosphorylation; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Purines; Roscovitine; Swine | 2015 |
Oocyte aging in a marine protostome worm: The roles of maturation-promoting factor and extracellular signal regulated kinase form of mitogen-activated protein kinase.
Topics: Animals; Apoptosis; Butadienes; Cells, Cultured; Cellular Senescence; Colforsin; Extracellular Signal-Regulated MAP Kinases; Female; Immunoblotting; Invertebrates; Maturation-Promoting Factor; Nitriles; Oocytes; Protein Kinase Inhibitors; Purines; Roscovitine; Seawater; Time Factors; Vasodilator Agents | 2016 |
Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling.
Topics: Animals; Apoptosis Regulatory Proteins; Butadienes; Caspase 3; Cells, Cultured; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase 5; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3 beta; Hippocampus; Maze Learning; Methyl Ethers; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Neurons; Nitriles; Phosphorylation; PPAR gamma; Purines; Roscovitine; Sevoflurane; Signal Transduction; tau Proteins | 2017 |
Non-centrosomal microtubule structures regulated by egg activation signaling contribute to cytoplasmic and cortical reorganization in the ascidian egg.
Topics: Animals; Butadienes; Calcium Signaling; Cell Cycle; Centrosome; Cyclin-Dependent Kinases; Male; Meiosis; Microtubules; Models, Biological; Nitriles; Ovum; Roscovitine; Signal Transduction; Spermatozoa; Urochordata | 2019 |
Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury.
Topics: Animals; Astrocytes; Butadienes; Constriction, Pathologic; Cyclin-Dependent Kinase 5; Disease Models, Animal; Enzyme Inhibitors; Male; MAP Kinase Signaling System; Nitriles; Phosphotransferases; PPAR gamma; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Roscovitine; Sciatic Neuropathy; Spinal Cord | 2019 |