Compounds > cyc 202
Page last updated: 2024-09-04

cyc 202 and sb 216763

cyc 202 has been researched along with sb 216763 in 8 studies

Compound Research Comparison

Studies
(cyc 202)		Trials
(cyc 202)		Recent Studies (post-2010)
(cyc 202)		Studies
(sb 216763)		Trials
(sb 216763)		Recent Studies (post-2010) (sb 216763)
97973933420225

Protein Interaction Comparison

ProteinTaxonomycyc 202 (IC50)sb 216763 (IC50)
G2/mitotic-specific cyclin-B2Homo sapiens (human)0.55
Cyclin-dependent kinase 1Homo sapiens (human)0.55
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.55
Cyclin-A2Homo sapiens (human)0.269
Cyclin-dependent kinase 2Homo sapiens (human)0.269
Glycogen synthase kinase-3 alphaHomo sapiens (human)0.0477
Glycogen synthase kinase-3 betaHomo sapiens (human)0.0342
Cyclin-A1Homo sapiens (human)0.269
G2/mitotic-specific cyclin-B3Homo sapiens (human)0.55

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Duan, Y; Han, J; Hou, S; Liao, C; Wang, Q; Xie, Z; Yang, X1
Ohyashiki, T; Takadera, T1
Chen, L; Li, X; Salinas, GD1
Chen, YY; Chien, CL; Han, SK; Kan, D; Lee, WC; Lu, KS1
Jin, X; Kong, X; Li, G; Liu, T; Wang, L1

Reviews

1 review(s) available for cyc 202 and sb 216763

ArticleYear
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
    Journal of medicinal chemistry, 2022, 05-12, Volume: 65, Issue:9

    Topics: Antineoplastic Agents; Cell Cycle; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Drug Discovery; Humans; Neoplasms; Protein Kinase Inhibitors

2022

Other Studies

7 other study(ies) available for cyc 202 and sb 216763

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Glycogen synthase kinase-3 inhibitors prevent caspase-dependent apoptosis induced by ethanol in cultured rat cortical neurons.
    European journal of pharmacology, 2004, Sep-24, Volume: 499, Issue:3

    Topics: Animals; Apoptosis; Calcium; Caspase 3; Caspase Inhibitors; Caspases; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinases; DNA Fragmentation; Dose-Response Relationship, Drug; Ethanol; Glycogen Synthase Kinase 3; Indoles; Intracellular Space; Maleimides; N-Methylaspartate; Peptides; Protein Kinase Inhibitors; Proteins; Purines; Rats; Roscovitine

2004
Regulation of serotonin 1B receptor by glycogen synthase kinase-3.
    Molecular pharmacology, 2009, Volume: 76, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Benzazepines; Cell Line; CHO Cells; Cholera Toxin; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Inbred BALB C; Oxadiazoles; Oximes; Piperidines; Piperidones; Protein Kinase Inhibitors; Purines; Pyridines; Receptor, Serotonin, 5-HT1B; Roscovitine; Serotonin; Spiro Compounds

2009
Suppression of extensive neurofilament phosphorylation rescues α-Internexin/peripherin-overexpressing PC12 cells from neuronal cell death.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Animals; Cell Death; Cell Survival; Cyclin-Dependent Kinase 5; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Intermediate Filament Proteins; Maleimides; Membrane Glycoproteins; Mitochondria; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; PC12 Cells; Peripherins; Phosphorylation; Protein Transport; Purines; Rats; Roscovitine

2012
Hippocampal glycogen synthase kinase 3β is critical for the antidepressant effect of cyclin-dependent kinase 5 inhibitor in rats.
    Journal of molecular neuroscience : MN, 2014, Volume: 54, Issue:1

    Topics: 4-Butyrolactone; Animals; Antidepressive Agents; Chromones; Cyclin-Dependent Kinase 5; Depression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Helplessness, Learned; Hippocampus; Indoles; Male; Maleimides; Morpholines; Purines; Rats; Rats, Sprague-Dawley; Roscovitine

2014