clonidine and u-50488

clonidine has been researched along with u-50488 in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19907 (28.00)18.7374
1990's9 (36.00)18.2507
2000's5 (20.00)29.6817
2010's3 (12.00)24.3611
2020's1 (4.00)2.80

Authors

AuthorsStudies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Brammer, MJ; Campbell, IC; Xiang, JZ1
Attali, B; Nah, SY; Vogel, Z1
Arts, KS; Fujimoto, J; Rady, J; Tseng, L1
Arts, KS; Fujimoto, JM; Rady, JJ; Tseng, LF1
Adamson, P; Brammer, MJ; Campbell, IC; Mantzourides, T; Xiang, JZ1
Louis, WJ; Verberne, AJ1
Adamson, P; Brammer, MJ; Campbell, IC; Hajimohammadreza, I; Mantzouridis, T; Xiang, JZ1
Conway, S; Koenig, JI; Krulich, L; Mayfield, MA; McCann, SM1
Schulz, R1
Belknap, JK; Danielson, PW; Laursen, SE; Noordewier, B1
Leander, JD1
Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K1
Paul, D; Tran, JG1
Baeyens, JM; OcaƱa, M1
Malmberg, AB; Yaksh, TL1
Amico, MC; Morrone, LA; Romanelli, L; Valeri, P1
Kishioka, S; Ko, MC; Woods, JH1
Krall, CM; McDougall, SA; Nazarian, A; Osburn, JR1
Baker, AK; Hoffmann, VL; Meert, TF1
Chernes, Y; Pick, CG; Rice, KC; Rigai, T; Schreiber, S1
Jun, JH; Kim, HJ; Lee, HJ; Seol, TK; Yaksh, TL1
Al-Hasani, R; Bruchas, MR; Foshage, AM; McCall, JG1
Diatchenko, L; Erasso, DM; Fu, ES; Kang, Y; Levitt, RC; Maixner, W; Martin, ER; Ozdemir, M; Sarantopoulos, KD; Smith, SB; Upadhyay, U; Wiltshire, T; Zhuang, GY1
Andoh, T; Konno, M; Kuraishi, Y; Suzuki, K; Tsuneyama, K1

Other Studies

25 other study(ies) available for clonidine and u-50488

ArticleYear
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Studies of receptor-mediated inhibition of 45Ca accumulation into synaptosomes.
    British journal of pharmacology, 1990, Volume: 101, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Calcium; Calcium Radioisotopes; Clonidine; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mitochondria; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Drug; Synaptosomes; Tetradecanoylphorbol Acetate; Vanadates

1990
Phorbol ester pretreatment desensitizes the inhibition of Ca2+ channels induced by kappa-opiate, alpha 2-adrenergic, and muscarinic receptor agonists.
    Journal of neurochemistry, 1991, Volume: 57, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Calcium Channels; Cell Communication; Cells, Cultured; Clonidine; Ganglia, Spinal; Kinetics; Neurons; Oxotremorine; Potassium; Pyrrolidines; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Tetradecanoylphorbol Acetate

1991
Intracerebroventricular analgesia enhanced by intrathecal (IT) dynorphin A(1-17) antibody.
    Progress in clinical and biological research, 1990, Volume: 328

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Physostigmine; Pyrrolidines

1990
Spinal dynorphin A (1-17): possible mediator of antianalgesic action.
    Neuropharmacology, 1990, Volume: 29, Issue:7

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antibodies; Clonidine; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Nociceptors; Physostigmine; Pyrrolidines; Spinal Cord

1990
Presynaptic alpha 2-adrenoceptor and kappa-opiate receptor occupancy promotes closure of neuronal (N-type) calcium channels.
    European journal of pharmacology, 1989, Dec-12, Volume: 174, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzofurans; Calcium; Calcium Channels; Clonidine; Dioxanes; Fura-2; Idazoxan; In Vitro Techniques; Male; Mollusk Venoms; Naloxone; Neurons; Nifedipine; omega-Conotoxin GVIA; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptosomes

1989
Interaction between the cardiovascular effects of clonidine and the kappa-opioid agonist U-50,488H in the anterior hypothalamic area of the rat brain.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Hypothalamus, Anterior; Male; Pyrrolidines; Rats; Rats, Inbred WKY; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors

1989
Alpha 2-adrenergic, kappa-opiate, and P1-purinergic autoreceptors have mutually antagonistic effects: a new regulatory mechanism?
    Journal of neurochemistry, 1989, Volume: 53, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Caffeine; Calcium; Cerebral Cortex; Clonidine; Dioxanes; Fluorescent Dyes; Fura-2; Homeostasis; Idazoxan; Male; Naloxone; Phenylisopropyladenosine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Purinergic; Synaptosomes

1989
Opioid kappa receptors and the secretion of prolactin (PRL) and growth hormone (GH) in the rat. II. GH and PRL release-inhibiting effects of the opioid kappa receptor agonists bremazocine and U-50,488.
    Neuroendocrinology, 1986, Volume: 42, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Clonidine; Growth Hormone; Injections, Intravenous; Male; Morphinans; Morphine; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Serotonin; Time Factors

1986
Dependence and cross-dependence in the guinea-pig myenteric plexus.
    Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 337, Issue:6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Drug Tolerance; Fentanyl; Guinea Pigs; Male; Morphine Dependence; Muscle Contraction; Myenteric Plexus; Pertussis Toxin; Pyrrolidines; Virulence Factors, Bordetella

1988
Selective breeding for levorphanol-induced antinociception on the hot-plate assay: commonalities in mechanism of action with morphine, pentazocine, ethylketocyclazocine, U-50488H and clonidine in mice.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Clonidine; Cyclazocine; Ethylketocyclazocine; Female; Levorphanol; Male; Mice; Morphine; Narcotics; Pain; Pentazocine; Pyrrolidines

1987
Kappa opioid agonists and antagonists: effects on drinking and urinary output.
    Appetite, 1984, Volume: 5, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Clonidine; Cyclazocine; Drinking; Ethylketocyclazocine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vasopressins

1984
Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H.
    Anesthesiology, 1995, Volume: 83, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Colon; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum

1995
Differential cross-tolerance between analgesia produced by alpha 2-adrenoceptor agonists and receptor subtype selective opioid treatments.
    European journal of pharmacology, 1995, Jan-05, Volume: 272, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics; Animals; Binding Sites; Clonidine; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Xylazine

1995
Differential effects of K+ channel blockers on antinociception induced by alpha 2-adrenoceptor, GABAB and kappa-opioid receptor agonists.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 4-Aminopyridine; Adrenergic alpha-Agonists; Analgesics; Animals; Baclofen; Clonidine; Drug Interactions; Female; Mice; Mice, Inbred Strains; Nociceptors; Potassium Channels; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, GABA; Receptors, Opioid, kappa; Sulfonylurea Compounds; Tetraethylammonium; Tetraethylammonium Compounds

1993
Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction.
    Anesthesiology, 1993, Volume: 79, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Drug Combinations; Drug Interactions; Formaldehyde; Ketorolac; Male; Morphine; Motor Activity; Nociceptors; Phenylisopropyladenosine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tolmetin

1993
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Nifedipine; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome

1993
Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys.
    European journal of pharmacology, 2000, May-26, Volume: 397, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzimidazoles; Calcium Channel Blockers; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Female; Fentanyl; Heroin; Macaca mulatta; Male; Morphine; Nalbuphine; Pain Measurement; Receptors, Opioid; Respiration; Time Factors

2000
Ultrasonic vocalizations of preweanling rats: involvement of both alpha(2)-adrenoceptor and kappa-opioid receptor systems.
    European journal of pharmacology, 2001, Volume: 415, Issue:2-3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Animals, Newborn; Animals, Suckling; Clonidine; Female; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Vocalization, Animal; Yohimbine

2001
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.
    Acta anaesthesiologica Belgica, 2002, Volume: 53, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzamides; Clonidine; Dextromethorphan; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Ketamine; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Piperazines; Reaction Time; Receptors, Opioid

2002
The antinociceptive effect of zolpidem and zopiclone in mice.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic Agonists; Adrenergic Antagonists; Analgesics; Animals; Azabicyclo Compounds; Behavior, Animal; Benzamides; Clonidine; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Piperazines; Pyridines; Receptors, Opioid; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Zolpidem

2005
The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats.
    Journal of anesthesia, 2011, Volume: 25, Issue:6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Animals; Burns; Clonidine; Enkephalin, D-Penicillamine (2,5)-; Hyperalgesia; Male; Morphine; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

2011
Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013, Volume: 38, Issue:12

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Cocaine; Conditioning, Psychological; Drug-Seeking Behavior; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Naltrexone; Propanolamines; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Opioid, kappa

2013
Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2017, Volume: 28, Issue:9-10

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Biomarkers, Tumor; Calcium; Clonidine; Dose-Response Relationship, Drug; Ganglia, Spinal; Gene Expression Regulation; Genetic Variation; Genome-Wide Association Study; Male; Mice; Morphine; Nerve Tissue Proteins; Pain Measurement; Pharmacogenomic Variants; Quantitative Trait Loci; Regulatory Sequences, Nucleic Acid

2017
Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus.
    Biological & pharmaceutical bulletin, 2020, Volume: 43, Issue:7

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-2 Receptor Agonists; Animals; Antipruritics; Bile Ducts; Cholestasis; Clonidine; Disease Models, Animal; Ligation; Liver; Male; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pruritus; Receptors, Opioid, kappa

2020