Page last updated: 2024-09-04

chs 828 and fk 866

chs 828 has been researched along with fk 866 in 9 studies

Compound Research Comparison

Studies
(chs 828)
Trials
(chs 828)
Recent Studies (post-2010)
(chs 828)
Studies
(fk 866)
Trials
(fk 866)
Recent Studies (post-2010) (fk 866)
210171883154

Protein Interaction Comparison

ProteinTaxonomychs 828 (IC50)fk 866 (IC50)
Cytochrome P450 1A2Homo sapiens (human)0.001
Cytochrome P450 3A4Homo sapiens (human)0.001
Cytochrome P450 2C9 Homo sapiens (human)0.001
Cytochrome P450 2C19Homo sapiens (human)0.001
Nicotinamide phosphoribosyltransferaseHomo sapiens (human)0.0095
Nicotinamide phosphoribosyltransferaseMus musculus (house mouse)0.0038

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boniface, JJ; Davis, T; Fleischer, TC; Flick, JS; Gao, ZH; McKinnon, R; Murphy, BR; Ostanin, K; Terry-Lorenzo, RT; Willardsen, JA1
Bair, KW; Bauer, P; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Dragovich, PS; Gunzner-Toste, J; Han, B; Ho, YC; Kley, N; Lin, J; Oh, A; Reynolds, DJ; Sharma, G; Smith, CC; Wang, W; Wang, Z; Yuen, PW; Zak, M; Zhao, G; Zheng, X1
Fakhfouri, G; Galli, U; Genazzani, AA; Massarotti, A; Rahimian, R; Travelli, C; Tron, GC1
Bair, KW; Bauer, P; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Dragovich, PS; Gunzner-Toste, J; Han, B; Ho, YC; Kley, N; Liederer, BM; Lin, J; Ly, J; O'Brien, T; Oh, A; Reynolds, DJ; Sharma, G; Smith, CC; Wang, L; Wang, W; Wang, Z; Xiao, Y; Yuen, PW; Zak, M; Zhao, G; Zheng, X1
Björkling, F; Christensen, MK; Erichsen, KD; Fristrup, P; Garten, A; Jensen, PB; Kalvinsh, I; Kiess, W; Loza, E; Nielsen, SJ; Olesen, UH; Sehested, M; Thougaard, A; Tjørnelund, J1
Bair, KW; Baumeister, T; Bravo, BJ; Cheng, E; Crocker, L; Dragovich, PS; Feng, Y; Giannetti, AM; Gunzner-Toste, J; Ho, YC; Hua, R; Liederer, BM; Liu, Y; Ma, X; O'Brien, T; Oeh, J; Sampath, D; Shen, Y; Skelton, NJ; Wang, C; Wang, L; Wang, W; Wu, H; Xiao, Y; Yuen, PW; Zak, M; Zhao, G; Zhao, Q; Zheng, X1
Bair, KW; Dragovich, PS; Ho, YC; Hua, R; Liederer, BM; Liu, X; O'Brien, T; Oeh, J; Patel, S; Sampath, D; Skelton, N; Sodhi, J; Wang, W; Wang, Y; Xiao, Y; Yuen, PW; Zak, M; Zhang, L; Zhao, G; Zheng, X1
Aguirre, AL; Algire, MA; Badagnani, I; Buchanan, FG; Cheng, D; Cheng, M; Chiang, GG; Clark, RF; Curtin, ML; Doherty, GA; Frey, RR; Guo, J; Hansen, TM; Heyman, HR; Korepanova, AV; Kovar, PJ; Longenecker, KL; Maag, D; Marin, VL; Michaelides, MR; Pliushchev, MA; Raich, D; Richardson, PL; Sarris, KA; Shrestha, A; Soni, NB; Sorensen, BK; Sweis, RF; Tse, C; Tu, N; Vasudevan, A; Wilsbacher, JL; Woller, K1
Alisi, MA; Aprile, S; Clemente, N; Colombo, G; Galli, U; Genazzani, AA; Grosa, G; Mattoteia, D; Polenzani, L; Scanziani, E; Terrazzino, S; Travelli, C; Tron, GC1

Reviews

1 review(s) available for chs 828 and fk 866

ArticleYear
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.
    Journal of medicinal chemistry, 2013, Aug-22, Volume: 56, Issue:16

    Topics: Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Nicotinamide Phosphoribosyltransferase; Structure-Activity Relationship

2013

Other Studies

8 other study(ies) available for chs 828 and fk 866

ArticleYear
Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound.
    Chemistry & biology, 2010, Jun-25, Volume: 17, Issue:6

    Topics: Antineoplastic Agents; Drug Discovery; HCT116 Cells; Humans; Nicotinamide Phosphoribosyltransferase; Orphan Drug Production; Proteomics; Quinazolines

2010
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
    Journal of medicinal chemistry, 2013, Jun-27, Volume: 56, Issue:12

    Topics: Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Nicotinamide Phosphoribosyltransferase; Protein Conformation; Structure-Activity Relationship; Urea

2013
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
    Journal of medicinal chemistry, 2013, Aug-22, Volume: 56, Issue:16

    Topics: Animals; Drug Discovery; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Nicotinamide Phosphoribosyltransferase; Spectrometry, Mass, Electrospray Ionization

2013
Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.
    Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Enzyme Inhibitors; Guanidines; Humans; Hydrogen Bonding; Hydroxamic Acids; Inhibitory Concentration 50; Mice; Molecular Docking Simulation; Nicotinamide Phosphoribosyltransferase; Protein Conformation; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2013
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
    Journal of medicinal chemistry, 2014, Feb-13, Volume: 57, Issue:3

    Topics: Amides; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Cyclopropanes; Drug Screening Assays, Antitumor; Heterografts; Humans; Mice; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Nicotinamide Phosphoribosyltransferase; Protein Conformation; Pyridines; Stereoisomerism; Structure-Activity Relationship; Sulfones

2014
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
    Journal of medicinal chemistry, 2016, 09-22, Volume: 59, Issue:18

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Drug Discovery; Enzyme Inhibitors; Female; Humans; Mice; Mice, Nude; Models, Molecular; Neoplasms; Nicotinamide Phosphoribosyltransferase; Pyridines

2016
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
    Bioorganic & medicinal chemistry letters, 2017, 08-01, Volume: 27, Issue:15

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Cytokines; Drug Discovery; Enzyme Inhibitors; Humans; Isoindoles; Mice; Models, Molecular; Neoplasms; Nicotinamide Phosphoribosyltransferase; Structure-Activity Relationship; Urea

2017
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group.
    European journal of medicinal chemistry, 2019, Nov-01, Volume: 181

    Topics: Animals; Cell Line, Tumor; Click Chemistry; Cytokines; Enzyme Inhibitors; Humans; Mice; Neoplasms; Nicotinamide Phosphoribosyltransferase; Triazoles

2019