chs 828 and fk 866
chs 828 has been researched along with fk 866 in 9 studies
Compound Research Comparison
| Studies (chs 828) | Trials (chs 828) | Recent Studies (post-2010) (chs 828) | Studies (fk 866) | Trials (fk 866) | Recent Studies (post-2010) (fk 866) |
|---|---|---|---|---|---|
| 21 | 0 | 17 | 188 | 3 | 154 |
Protein Interaction Comparison
| Protein | Taxonomy | chs 828 (IC50) | fk 866 (IC50) |
|---|---|---|---|
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.001 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.001 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.001 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.001 | |
| Nicotinamide phosphoribosyltransferase | Homo sapiens (human) | 0.0095 | |
| Nicotinamide phosphoribosyltransferase | Mus musculus (house mouse) | 0.0038 |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Boniface, JJ; Davis, T; Fleischer, TC; Flick, JS; Gao, ZH; McKinnon, R; Murphy, BR; Ostanin, K; Terry-Lorenzo, RT; Willardsen, JA | 1 |
| Bair, KW; Bauer, P; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Dragovich, PS; Gunzner-Toste, J; Han, B; Ho, YC; Kley, N; Lin, J; Oh, A; Reynolds, DJ; Sharma, G; Smith, CC; Wang, W; Wang, Z; Yuen, PW; Zak, M; Zhao, G; Zheng, X | 1 |
| Fakhfouri, G; Galli, U; Genazzani, AA; Massarotti, A; Rahimian, R; Travelli, C; Tron, GC | 1 |
| Bair, KW; Bauer, P; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Dragovich, PS; Gunzner-Toste, J; Han, B; Ho, YC; Kley, N; Liederer, BM; Lin, J; Ly, J; O'Brien, T; Oh, A; Reynolds, DJ; Sharma, G; Smith, CC; Wang, L; Wang, W; Wang, Z; Xiao, Y; Yuen, PW; Zak, M; Zhao, G; Zheng, X | 1 |
| Björkling, F; Christensen, MK; Erichsen, KD; Fristrup, P; Garten, A; Jensen, PB; Kalvinsh, I; Kiess, W; Loza, E; Nielsen, SJ; Olesen, UH; Sehested, M; Thougaard, A; Tjørnelund, J | 1 |
| Bair, KW; Baumeister, T; Bravo, BJ; Cheng, E; Crocker, L; Dragovich, PS; Feng, Y; Giannetti, AM; Gunzner-Toste, J; Ho, YC; Hua, R; Liederer, BM; Liu, Y; Ma, X; O'Brien, T; Oeh, J; Sampath, D; Shen, Y; Skelton, NJ; Wang, C; Wang, L; Wang, W; Wu, H; Xiao, Y; Yuen, PW; Zak, M; Zhao, G; Zhao, Q; Zheng, X | 1 |
| Bair, KW; Dragovich, PS; Ho, YC; Hua, R; Liederer, BM; Liu, X; O'Brien, T; Oeh, J; Patel, S; Sampath, D; Skelton, N; Sodhi, J; Wang, W; Wang, Y; Xiao, Y; Yuen, PW; Zak, M; Zhang, L; Zhao, G; Zheng, X | 1 |
| Aguirre, AL; Algire, MA; Badagnani, I; Buchanan, FG; Cheng, D; Cheng, M; Chiang, GG; Clark, RF; Curtin, ML; Doherty, GA; Frey, RR; Guo, J; Hansen, TM; Heyman, HR; Korepanova, AV; Kovar, PJ; Longenecker, KL; Maag, D; Marin, VL; Michaelides, MR; Pliushchev, MA; Raich, D; Richardson, PL; Sarris, KA; Shrestha, A; Soni, NB; Sorensen, BK; Sweis, RF; Tse, C; Tu, N; Vasudevan, A; Wilsbacher, JL; Woller, K | 1 |
| Alisi, MA; Aprile, S; Clemente, N; Colombo, G; Galli, U; Genazzani, AA; Grosa, G; Mattoteia, D; Polenzani, L; Scanziani, E; Terrazzino, S; Travelli, C; Tron, GC | 1 |
Reviews
1 review(s) available for chs 828 and fk 866
| Article | Year |
|---|---|
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.
Topics: Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Nicotinamide Phosphoribosyltransferase; Structure-Activity Relationship | 2013 |
Other Studies
8 other study(ies) available for chs 828 and fk 866
| Article | Year |
|---|---|
Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound.
Topics: Antineoplastic Agents; Drug Discovery; HCT116 Cells; Humans; Nicotinamide Phosphoribosyltransferase; Orphan Drug Production; Proteomics; Quinazolines | 2010 |
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Topics: Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Nicotinamide Phosphoribosyltransferase; Protein Conformation; Structure-Activity Relationship; Urea | 2013 |
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
Topics: Animals; Drug Discovery; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Nicotinamide Phosphoribosyltransferase; Spectrometry, Mass, Electrospray Ionization | 2013 |
Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Enzyme Inhibitors; Guanidines; Humans; Hydrogen Bonding; Hydroxamic Acids; Inhibitory Concentration 50; Mice; Molecular Docking Simulation; Nicotinamide Phosphoribosyltransferase; Protein Conformation; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2013 |
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Topics: Amides; Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Cyclopropanes; Drug Screening Assays, Antitumor; Heterografts; Humans; Mice; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Nicotinamide Phosphoribosyltransferase; Protein Conformation; Pyridines; Stereoisomerism; Structure-Activity Relationship; Sulfones | 2014 |
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Drug Discovery; Enzyme Inhibitors; Female; Humans; Mice; Mice, Nude; Models, Molecular; Neoplasms; Nicotinamide Phosphoribosyltransferase; Pyridines | 2016 |
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Cytokines; Drug Discovery; Enzyme Inhibitors; Humans; Isoindoles; Mice; Models, Molecular; Neoplasms; Nicotinamide Phosphoribosyltransferase; Structure-Activity Relationship; Urea | 2017 |
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group.
Topics: Animals; Cell Line, Tumor; Click Chemistry; Cytokines; Enzyme Inhibitors; Humans; Mice; Neoplasms; Nicotinamide Phosphoribosyltransferase; Triazoles | 2019 |