cgp 46381 has been researched along with baclofen in 7 studies
| Studies (cgp 46381) | Trials (cgp 46381) | Recent Studies (post-2010) (cgp 46381) | Studies (baclofen) | Trials (baclofen) | Recent Studies (post-2010) (baclofen) |
|---|---|---|---|---|---|
| 25 | 0 | 5 | 6,017 | 372 | 1,535 |
| Protein | Taxonomy | cgp 46381 (IC50) | baclofen (IC50) |
|---|---|---|---|
| Gamma-aminobutyric acid type B receptor subunit 2 | Homo sapiens (human) | 0.05 | |
| Gamma-aminobutyric acid type B receptor subunit 2 | Rattus norvegicus (Norway rat) | 0.2762 | |
| Gamma-aminobutyric acid type B receptor subunit 1 | Homo sapiens (human) | 0.05 | |
| Gamma-aminobutyric acid type B receptor subunit 1 | Rattus norvegicus (Norway rat) | 0.2762 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Curtis, DR; Lacey, G | 1 |
| Bowery, NG; Da Silva, H; Malcangio, M | 1 |
| Bexis, S; Ong, J; White, J | 1 |
| Duty, S; Johnston, T | 1 |
| Chai, CY; Cheng, YW; Ho, CM; Ku, MC; Su, CK | 1 |
| Hampson, DR; Heximer, SP; Pacey, LK | 1 |
| Cheng, ZY; Han, XG; Schmid, KL; Wang, XP | 1 |
7 other study(ies) available for cgp 46381 and baclofen
| Article | Year |
|---|---|
GABA-B receptor-mediated spinal inhibition.
Topics: Afferent Pathways; Animals; Baclofen; Bicuculline; Cats; Decerebrate State; Depression, Chemical; GABA Antagonists; gamma-Aminobutyric Acid; Organophosphorus Compounds; Phosphinic Acids; Receptors, GABA; Reflex, Monosynaptic; Spinal Cord; Tetany | 1994 |
Plasticity of GABAB receptor in rat spinal cord detected by autoradiography.
Topics: Animals; Autoradiography; Baclofen; Binding Sites; gamma-Aminobutyric Acid; Organophosphorus Compounds; Phosphinic Acids; Rats; Receptors, GABA-B; Spinal Cord; Up-Regulation | 1993 |
Attenuation of morphine withdrawal signs by the GABA(B) receptor agonist baclofen.
Topics: Animals; Baclofen; Behavior, Animal; Drug Antagonism; Drug Combinations; GABA Agonists; GABA Antagonists; Male; Morphine Dependence; Naloxone; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2001 |
GABA(B) receptor agonists reverse akinesia following intranigral or intracerebroventricular injection in the reserpine-treated rat.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Globus Pallidus; Hypokinesia; Injections, Intraventricular; Male; Motor Activity; Organophosphorus Compounds; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Reserpine; Substantia Nigra | 2003 |
GABAB-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats.
Topics: Age Factors; Animals; Animals, Newborn; Baclofen; Cadmium; Calcium; Cesium; GABA Agonists; GABA Antagonists; Hypertension; Membrane Potentials; Neural Inhibition; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Spinal Cord; Splanchnic Nerves; Sympathetic Nervous System | 2005 |
Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures.
Topics: Animals; Baclofen; Disease Susceptibility; Female; Fragile X Mental Retardation Protein; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphinic Acids; Receptor, Metabotropic Glutamate 5; Receptors, GABA-B; Receptors, Metabotropic Glutamate; RGS Proteins; Seizures; Signal Transduction | 2009 |
GABAB1 and GABAB2 receptor subunits co-expressed in cultured human RPE cells regulate intracellular Ca2+ via Gi/o-protein and phospholipase C pathways.
Topics: Baclofen; Calcium; Cells, Cultured; Enzyme Inhibitors; Estrenes; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Intracellular Space; Pertussis Toxin; Phosphinic Acids; Pyrrolidinones; Receptors, GABA-A; Retinal Pigment Epithelium; RNA, Messenger; Type C Phospholipases | 2014 |