Page last updated: 2024-09-05

biotin and desthiobiotin

biotin has been researched along with desthiobiotin in 113 studies

Compound Research Comparison

Studies
(biotin)
Trials
(biotin)
Recent Studies (post-2010)
(biotin)
Studies
(desthiobiotin)
Trials
(desthiobiotin)
Recent Studies (post-2010) (desthiobiotin)
14,847953,882123041

Protein Interaction Comparison

ProteinTaxonomybiotin (IC50)desthiobiotin (IC50)
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))1.57
photoreceptor-specific nuclear receptorHomo sapiens (human)0.1491
nuclear receptor corepressor 2 isoform 2Homo sapiens (human)1.378
peroxisome proliferator-activated receptor gamma isoform 2Homo sapiens (human)1.378

Research

Studies (113)

TimeframeStudies, this research(%)All Research%
pre-199026 (23.01)18.7374
1990's21 (18.58)18.2507
2000's25 (22.12)29.6817
2010's35 (30.97)24.3611
2020's6 (5.31)2.80

Authors

AuthorsStudies
Bednar, B; Cunningham, ME; Kapitskaya, M; Kornienko, O; Lacson, R; Petrukhin, K1
Barker, D; Campbell, A; Campillo-Campbell, AD1
Frappier, F; Guillerm, G; Marquet, A; Salib, AG1
Chen, CS; De Titta, GT; Parthasarathy, R1
Fukushima, S; Haze, S; Ifuku, O; Kishimoto, J; Yanagi, M1
Said, HM1
Bernard, S; Gloeckler, R; Kamogawa, K; Kisou, T; Ledoux, C; Lemoine, Y; Ohsawa, I; Speck, D; Villeval, D; Zinsius, M1
Dinkins, R; Meinke, DW; Robinson, K; Schneider, T; Shellhammer, J1
Nylander, W; Redha, R; Said, HM1
Izumi, Y; Osakai, M; Tamura, K; Yamada, H1
DeMoll, E; Shive, W1
Imanishi, Y; Ohsugi, M1
Bothner-By, AA; Finn, FM; Hofmann, K; Mishra, PK; Romovacek, H; Zhang, WJ1
Azoulay, M; Desbene, PL; Frappier, F; Georges, Y1
Frappier, F; Guillerm, G; Tabet, JC1
Henderson, GI; Hu, ZQ; Mock, DM; Schenker, S1
Bui, BT; Florentin, D; Izumi, Y; Marquet, A; Ohshiro, T; Yamamoto, M2
Florin, EL; Gaub, HE; Moy, VT2
Haze, S; Ifuku, O; Kishimoto, J; Koga, N; Wachi, Y1
Flint, D; Gibson, KJ; Huang, W; Lindqvist, Y; Lorimer, G; Schneider, G1
Cohen, G; Flint, DH; Sanyal, I1
Chiruvolu, S; Israelachvili, J; Leckband, D; Schmitt, FJ; Walker, S; Zasadzinski, JA1
Bowman, WC; DeMoll, E1
Elliott, BD; Frosto, T; Henderson, GI; Hu, ZQ; Johnson, RF; Mock, DM; Schenker, S; Yang, Y1
Bui, BT; Florentin, D; Izumi, Y; Marquet, A; Méjean, A; Ploux, O1
Florentin, D; Jestin, E; Marquet, A; Moreau, F1
Gibson, KJ1
Skerra, A; Voss, S1
Gibson, KJ; Käck, H; Lindqvist, Y; Schneider, G1
Gibson, KJ; Käck, H; Lindqvist, Y; Sandmark, J; Schneider, G1
David, GS; Knowles, SK; Nova, MP; Parandoosh, Z; Xiao, XY; Zhao, C1
Baldwin, JE; Birch, OM; Burgdorf, K; Fuhrmann, M; Hewitson, KS; Roach, PL; Shaw, NM1
Baumgartner, ER; Baur, B; Suormala, T1
Fontecave, M; Hewitson, KS; Münck, E; Ollagnier-de Choudens, S; Roach, P; Sanakis, Y1
Beechem, JM; Eslamizar, L; Filanoski, BJ; Haugland, RP; Hirsch, JD; Malekzadeh, N1
Asakura, A; Hoshino, T; Kiyasu, T; Nagahashi, Y1
Frederick, KK; Jarrett, JT; Ugulava, NB1
Lewis, B; McMahon, RJ; Rodriguez-Melendez, R; Zempleni, J1
COSCARELLI, W; PRAMER, D1
EISENBERG, MA1
NIMURA, T; SAHASHI, Y; SUZUKI, T3
LICHSTEIN, HC; PAI, CH1
Berkovitch, F; Drennan, CL; Jarrett, JT; Nicolet, Y; Wan, JT1
Cosper, MM; Hernández, HL; Huynh, BH; Jameson, GN; Johnson, MK1
Wong, SL; Wu, SC1
Escalettes, F; Florentin, D; Lotierzo, M; Marquet, A; Tse Sum Bui, B2
Choi-Rhee, E; Cronan, JE2
Seki, M1
Angelov, GS; Baumgaertner, P; Guillaume, P; Luescher, IF; Speiser, D1
Balser, S; Flauger, B; Gerl, MJ; Lill, R; Mühlenhoff, U; Pirner, HM; Richhardt, N; Stolz, J1
Boldt, K; Gloeckner, CJ; Roepman, R; Schumacher, A; Ueffing, M1
Abdel-Hamid, AM; Cronan, JE1
SWAIN, G1
Patchornik, G1
Aizawa, Y; Funatsu, T; Kato, T; Sakamoto, A; Watanabe, T; Yamagishi, M1
Farrar, CE; Jarrett, JT; Taylor, AM1
DUSCHINSKY, R; RUBIN, SH1
PERLMAN, D1
Berezovski, MV; Drabovich, AP; Krylov, SN; Musheev, MU1
Farrar, CE; Jarrett, JT1
SCHULTZ, EM1
Chen, R; Darling, D; Farzaneh, F; Folarin, N; Ho, VH; McNally, D; Slater, NK1
Delli-Bovi, TA; Prigge, ST; Spalding, MD1
BROWN, GB; Du VIGNEAUD, V1
BROWN, GB; FERGER, MF1
DOLAN, LA; DUSCHINSKY, R2
TATUM, EL1
Almo, SC; Czekster, CM; Guan, R; Levy, M; Magalhães, ML; Malashkevich, VN1
Aldrich, CC; Duckworth, BP; Manjunatha, U; Muretta, JM; Sham, YY; Shi, C; Thomas, DD; Wilson, DJ1
Fugate, CJ; Jarrett, JT1
Alban, C; Cobessi, D; Dumas, R; Ferrer, JL; Meinguet, C; Pautre, V1
Deniaud, A; Panwar, P; Pebay-Peyroula, E1
Ikeda, M; Kitano, Y; Mitsuhashi, S; Miyamoto, A; Mutoh, S; Shirakura, D; Tajima, M; Takasaki, M; Takeno, S1
Colby, T; Kaiser, M; Kaschani, F; Oeljeklaus, J; Patricelli, MP; van der Hoorn, RA; Villamor, JG; Zhao, D1
Burley, GA; Dawson, MD; Guilhabert, B; Haughey, AM; Kanibolotsky, AL; Laurand, N; Skabara, PJ1
Ellington, AD; Kincaid, R; Levy, M; Lu, WC1
Atkins, C; Evans, CW; Noah, JW; Nordin, B; Patricelli, MP; Reynolds, R; Wennerberg, K1
Jain, T; Liu, DR; McGregor, LM1
Ellington, AD; Lu, WC1
Ghosal, A; Said, HM; Sekar, TV1
Burley, GA; Dawson, MD; Guilhabert, B; Haughey, AM; Laurand, N1
Amos, JR; Ansari, A; Imoukhuede, PI; Lee-Montiel, FT1
Bai, Y; Chen, YA; Fang, B; Haura, EB; Kim, JY; Kinose, F; Koomen, JM; Li, J; Rix, U1
Basseguy, R; Gauquelin, C; Meynial-Salles, I; Rouvre, I1
Chen, X; Fan, X; Li, H1
Magwamba, CC; Palittapongarnpim, P; Rukseree, K1
Ford, HR; Grishin, AV; Wang, J1
Ahrens, M; Bracht, T; Eisenacher, M; Knobloch, J; Koch, A; Megger, DA; Müller, C; Rosowski, K; Sitek, B; Witzke, KE1
Friedl, G; Gruber, HJ; Knoglinger, C; Müller, K; Poslední, K; Ruttmann, B; Schorpp, A; Traxler, L; Zich, A; Zimmermann, M1
Chen, X; Ferguson, ML; Hayden, EJ; Hoskins, AA; Panchapakesan, SSS; Unrau, PJ1
Huynh, V; Wylie, RG1
Huynh, V; Lambert, CR; Nijsure, D; Wylie, RG1
Felley-Bosco, E; Kresoja-Rakic, J1
Britt, RD; Fugate, CJ; Jarrett, JT; Stich, TA; Tao, L1
Aggarwal, K; Fikes, AG; Greer, SM; Mehta, R; Ngo, C; Que, EL; Santos, IC1
An, J; Cheng, K; Li, C; Liu, B; Song, YY; Xuan, Y; Yang, XQ; Zhang, MZ; Zhang, XS; Zhao, YD1
Maresh, ME; Trader, DJ1
Miranda, V; Torcato, IM; Ventura, MR; Xavier, KB1
Ding, Y; Hunter, CA; Williams, NH1
Dalal, S; Dapper, C; Elahi, R; Helm, RF; Klemba, M; Ray, WK1
Hacker, SM; Lewald, L; Zanon, PRA1
Kapcan, E; Lake, B; Rullo, AF; Serniuck, N; Wang, A1
Bali, AP; Buerger, J; Genee, HJ; Gronenberg, LS; Lennox-Hvenekilde, D; Myling-Petersen, N; Salomonsen, B; Sommer, MOA1
Cai, R; Dong, X; He, X; Liu, X; Wang, Y; Yu, K1
Chen, C; Lin, J; Su, L; Sun, M; Wang, J; Yan, X1
Bruns, S; Dlugosch, L; Groon, LA; Simon, M; Sultana, S; Wienhausen, G; Wilkes, H1

Reviews

3 review(s) available for biotin and desthiobiotin

ArticleYear
Biotin synthase mechanism: an overview.
    Biochemical Society transactions, 2005, Volume: 33, Issue:Pt 4

    Topics: Biotin; Free Radicals; Iron-Sulfur Proteins; Kinetics; Sulfur; Sulfurtransferases

2005
Biological significance and development of practical synthesis of biotin.
    Medicinal research reviews, 2006, Volume: 26, Issue:4

    Topics: Animals; Avidin; Biotin; Catalysis; Cysteine; Hypoglycemic Agents; Insulin; Insulin Secretion; Iron; Lactones; Models, Biological; Models, Chemical; Pimelic Acids; Rhizobium

2006
Biotin synthase: insights into radical-mediated carbon-sulfur bond formation.
    Biochimica et biophysica acta, 2012, Volume: 1824, Issue:11

    Topics: Bacterial Proteins; Biocatalysis; Biotin; Carbon; Free Radicals; Fungal Proteins; Iron-Sulfur Proteins; Kinetics; Models, Molecular; Plants; S-Adenosylmethionine; Sulfur; Sulfurtransferases; Thermodynamics

2012

Other Studies

110 other study(ies) available for biotin and desthiobiotin

ArticleYear
Development of the high throughput screening assay for identification of agonists of an orphan nuclear receptor.
    Assay and drug development technologies, 2006, Volume: 4, Issue:3

    Topics: Animals; Biological Assay; CHO Cells; Cricetinae; Cricetulus; Drug Design; Flow Cytometry; Orphan Nuclear Receptors; Pharmaceutical Preparations; Protein Interaction Mapping; Receptors, Cytoplasmic and Nuclear; Transcription Factors

2006
Repression of biotin biosynthesis in Escherichia coli during growth on biotin vitamers.
    Journal of bacteriology, 1978, Volume: 135, Issue:1

    Topics: beta-Galactosidase; Biotin; Enzyme Repression; Escherichia coli; Galactosidases; Mutation; Transduction, Genetic

1978
On the mechanism of conversion of dethiobiotin to biotin in Escherichia coli. Discussion of the occurrence of an intermediate hydroxylation.
    Biochemical and biophysical research communications, 1979, Nov-28, Volume: 91, Issue:2

    Topics: Biological Transport; Biotin; Escherichia coli; Hydroxylation; Kinetics

1979
Crystal and molecular structure of d, l-dethiobiotin. Role of sulfur in biotin stereochemistry.
    Journal of the American Chemical Society, 1976, Aug-04, Volume: 98, Issue:16

    Topics: Biotin; Chemical Phenomena; Chemistry; Hot Temperature; Hydrogen Bonding; Molecular Conformation; Stereoisomerism; Sulfur; X-Ray Diffraction

1976
Conversion of dethiobiotin to biotin in cell-free extracts of Escherichia coli.
    Bioscience, biotechnology, and biochemistry, 1992, Volume: 56, Issue:11

    Topics: Base Sequence; Biotechnology; Biotin; Cell-Free System; DNA, Bacterial; Enzymes; Escherichia coli; Fructosediphosphates; Genes, Bacterial; Molecular Sequence Data; Plasmids

1992
Movement of biotin across the rat intestinal basolateral membrane. Studies with membrane vesicles.
    The Biochemical journal, 1991, Nov-01, Volume: 279 ( Pt 3)

    Topics: Animals; Anions; Biological Transport; Biotin; Cell Membrane; Intestinal Mucosa; Jejunum; Membrane Potentials; Rats; Rats, Inbred Strains; Thioctic Acid; Time Factors

1991
Cloning and characterization of the Bacillus sphaericus genes controlling the bioconversion of pimelate into dethiobiotin.
    Gene, 1990, Mar-01, Volume: 87, Issue:1

    Topics: Bacillus; Bacillus subtilis; Base Sequence; Biotin; Biotransformation; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Genotype; Molecular Sequence Data; Mutation; Pimelic Acids; Restriction Mapping

1990
An embryo-lethal mutant of Arabidopsis thaliana is a biotin auxotroph.
    Developmental biology, 1989, Volume: 131, Issue:1

    Topics: Biotin; Culture Techniques; Genes, Lethal; Homozygote; Mutation; Plant Development; Plants; Seeds

1989
A carrier-mediated, Na+ gradient-dependent transport for biotin in human intestinal brush-border membrane vesicles.
    The American journal of physiology, 1987, Volume: 253, Issue:5 Pt 1

    Topics: Biological Transport; Biotin; Carrier Proteins; Humans; Intestinal Mucosa; Jejunum; Kinetics; Male; Membrane Potentials; Microvilli; Middle Aged; Osmolar Concentration; Sodium; Thioctic Acid

1987
Reinvestigation of compound X, a suspected biotin intermediate: identification of N-formyl derivatives of biotin and dethiobiotin.
    Journal of nutritional science and vitaminology, 1986, Volume: 32, Issue:3

    Topics: Biotin; Chromatography, Ion Exchange; Diazomethane; Escherichia coli

1986
Assay for biotin in the presence of dethiobiotin with Lactobacillus plantarum.
    Analytical biochemistry, 1986, Volume: 158, Issue:1

    Topics: Biological Assay; Biotin; Lactobacillus

1986
Microbiological activity of biotin-vitamers.
    Journal of nutritional science and vitaminology, 1985, Volume: 31, Issue:6

    Topics: Amino Acids; Amino Acids, Diamino; Bacteria; Biotin; Culture Media; Fatty Acids; Growth Substances; Lysine; Pimelic Acids; Yeasts

1985
Syntheses of biotinylated and dethiobiotinylated insulins.
    Biochemistry, 1984, Jun-05, Volume: 23, Issue:12

    Topics: Animals; Biotin; Cattle; Indicators and Reagents; Insulin; Magnetic Resonance Spectroscopy; Molecular Conformation; Protein Binding; Spectrometry, Fluorescence

1984
Use of liquid chromatography-mass spectrometry for the quantitation of dethiobiotin and biotin in biological samples.
    Journal of chromatography, 1984, Oct-26, Volume: 303, Issue:1

    Topics: Bacillus; Biotin; Chromatography, Liquid; Mass Spectrometry

1984
The application of low voltge mass spectrometry to the determination of extent and location of deuterium substitution in dethiobiotin.
    Biomedical mass spectrometry, 1980, Volume: 7, Issue:5

    Topics: Biotin; Deuterium; Electrons; Mass Spectrometry

1980
Biotin uptake by basolateral membrane vesicles of human placenta: normal characteristics and role of ethanol.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1994, Volume: 206, Issue:4

    Topics: Biotin; Cell Membrane; Ethanol; Female; Gramicidin; Humans; In Vitro Techniques; Kinetics; Lysine; Mannitol; Membrane Potentials; Osmolar Concentration; Placenta; Valinomycin

1994
Enzymatic conversion of dethiobiotin to biotin in cell-free extracts of a Bacillus sphaericus bioB transformant.
    Bioscience, biotechnology, and biochemistry, 1994, Volume: 58, Issue:9

    Topics: Bacillus; Bacterial Proteins; Biotin; Cell-Free System; Coenzymes; Kinetics; Metals; Sulfur; Sulfurtransferases; Transformation, Bacterial

1994
Stimulatory factors for enzymatic biotin synthesis from dethiobiotin in cell-free extracts of Escherichia coli.
    Bioscience, biotechnology, and biochemistry, 1995, Volume: 59, Issue:5

    Topics: Bacillus; Biotin; Cell Extracts; Cysteine; Escherichia coli; Flavin-Adenine Dinucleotide; Immunosuppressive Agents; NAD; NADP; S-Adenosylmethionine

1995
Intermolecular forces and energies between ligands and receptors.
    Science (New York, N.Y.), 1994, Oct-14, Volume: 266, Issue:5183

    Topics: Avidin; Bacterial Proteins; Biotin; Hydrogen-Ion Concentration; Ligands; Models, Chemical; Receptors, Drug; Streptavidin; Thermodynamics

1994
Flavodoxin is required for conversion of dethiobiotin to biotin in Escherichia coli.
    European journal of biochemistry, 1994, Aug-15, Volume: 224, Issue:1

    Topics: Amino Acid Sequence; Biotin; Cell-Free System; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Flavodoxin; Molecular Sequence Data; Molecular Weight; Polyethyleneimine

1994
Crystal structure of an ATP-dependent carboxylase, dethiobiotin synthetase, at 1.65 A resolution.
    Structure (London, England : 1993), 1994, May-15, Volume: 2, Issue:5

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Bacillus; Binding Sites; Biotin; Carbon Dioxide; Carbon-Nitrogen Ligases; Crystallography, X-Ray; Escherichia coli; Ligases; Models, Molecular; Molecular Sequence Data; Protein Conformation; Recombinant Proteins

1994
Biotin synthase: purification, characterization as a [2Fe-2S]cluster protein, and in vitro activity of the Escherichia coli bioB gene product.
    Biochemistry, 1994, Mar-29, Volume: 33, Issue:12

    Topics: Amino Acid Sequence; Biotin; Dithionite; Electron Spin Resonance Spectroscopy; Escherichia coli; Genes, Bacterial; Iron-Sulfur Proteins; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; NADP; Oxidation-Reduction; Potassium Chloride; Spectrophotometry; Sulfurtransferases

1994
Adhesion forces between individual ligand-receptor pairs.
    Science (New York, N.Y.), 1994, Apr-15, Volume: 264, Issue:5157

    Topics: Adhesiveness; Avidin; Biotin; Ligands; Microscopy; Microspheres; Receptors, Cell Surface; Sepharose

1994
Higher order self-assembly of vesicles by site-specific binding.
    Science (New York, N.Y.), 1994, Jun-17, Volume: 264, Issue:5166

    Topics: Adhesiveness; Bacterial Proteins; Biotin; Colloids; Freeze Fracturing; Lipid Bilayers; Liposomes; Mathematics; Microscopy, Electron; Phosphatidylcholines; Phosphatidylethanolamines; Streptavidin; Surface Properties

1994
Biosynthesis of biotin from dethiobiotin by the biotin auxotroph Lactobacillus plantarum.
    Journal of bacteriology, 1993, Volume: 175, Issue:23

    Topics: Biological Assay; Biotin; Genetic Variation; Lactobacillus

1993
Human placental biotin transport: normal characteristics and effect of ethanol.
    Alcoholism, clinical and experimental research, 1993, Volume: 17, Issue:3

    Topics: Biotin; Culture Techniques; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Humans; Infant, Newborn; Lysine; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Trophoblasts

1993
Highly purified biotin synthase can transform dethiobiotin into biotin in the absence of any other protein, in the presence of photoreduced deazaflavin.
    Biochemical and biophysical research communications, 1995, Dec-26, Volume: 217, Issue:3

    Topics: Amino Acid Sequence; Bacillus; Biotin; Cell-Free System; Cysteine; Flavins; Molecular Sequence Data; Spectrum Analysis; Sulfur; Sulfurtransferases

1995
Synthesis and biochemical properties of Z- and E-4,5-dehydrodethiobiotin.
    Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:7

    Topics: Biotin; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Imidazoles; Sulfurtransferases

1996
Isolation and chemistry of the mixed anhydride intermediate in the reaction catalyzed by dethiobiotin synthetase.
    Biochemistry, 1997, Jul-15, Volume: 36, Issue:28

    Topics: Adenosine Triphosphate; Amino Acids, Diamino; Anhydrides; Biotin; Carbamates; Carbon Dioxide; Carbon-Nitrogen Ligases; Chromatography, Thin Layer; Escherichia coli; Kinetics; Ligases; Molecular Structure; Phosphates; Phosphorylation

1997
Mutagenesis of a flexible loop in streptavidin leads to higher affinity for the Strep-tag II peptide and improved performance in recombinant protein purification.
    Protein engineering, 1997, Volume: 10, Issue:8

    Topics: Affinity Labels; Alkaline Phosphatase; Binding, Competitive; Biotin; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Fluorescence; Gene Library; Models, Molecular; Mutagenesis; Oligopeptides; Protein Conformation; Protein Engineering; Recombinant Fusion Proteins; Streptavidin

1997
Snapshot of a phosphorylated substrate intermediate by kinetic crystallography.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, May-12, Volume: 95, Issue:10

    Topics: Adenosine Triphosphate; Amino Acids, Diamino; Biotin; Carbon Dioxide; Carbon-Nitrogen Ligases; Catalysis; Crystallography, X-Ray; Escherichia coli; Kinetics; Models, Molecular; Phosphorylation; Protein Conformation

1998
Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis.
    Protein science : a publication of the Protein Society, 1998, Volume: 7, Issue:12

    Topics: Adenosine Diphosphate; Aluminum Compounds; Amino Acids, Diamino; Biotin; Carbon-Nitrogen Ligases; Catalytic Domain; Crystallography, X-Ray; Fluorides; Magnesium; Models, Molecular; Phosphates; Phosphorylation; Protein Conformation

1998
Encoded chemical synthesis coupled to screening: "Pot Assay".
    Combinatorial chemistry & high throughput screening, 1998, Volume: 1, Issue:3

    Topics: Alkaline Phosphatase; Biotin; Chemistry, Pharmaceutical; Drug Evaluation, Preclinical; Iodine Radioisotopes; Luminescent Measurements; Radio Waves; Streptavidin

1998
MioC is an FMN-binding protein that is essential for Escherichia coli biotin synthase activity in vitro.
    The Journal of biological chemistry, 2000, Oct-13, Volume: 275, Issue:41

    Topics: Apoproteins; Bacterial Proteins; Biotin; Cloning, Molecular; Electron Transport; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Flavin Mononucleotide; Flavodoxin; Flavoproteins; Molecular Weight; Protein Binding; Sequence Analysis, Protein; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Sulfurtransferases

2000
Biocytin and biotin uptake into NB2a neuroblastoma and C6 astrocytoma cells.
    Brain research, 2002, Jan-25, Volume: 925, Issue:2

    Topics: Animals; Astrocytoma; Binding, Competitive; Biological Transport; Biotin; Carbon-Carbon Ligases; Cell Line, Transformed; Choline; Dose-Response Relationship, Drug; Enzyme Activation; Lysine; Mice; Neuroblastoma; Neuroglia; Neurons; Potassium; Rats; Sodium; Thioctic Acid

2002
Reductive cleavage of S-adenosylmethionine by biotin synthase from Escherichia coli.
    The Journal of biological chemistry, 2002, Apr-19, Volume: 277, Issue:16

    Topics: Biotin; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Kinetics; Methionine; Models, Chemical; Mutation; S-Adenosylmethionine; Spectroscopy, Mossbauer; Sulfurtransferases; Time Factors

2002
Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: uses for protein labeling, detection, and isolation.
    Analytical biochemistry, 2002, Sep-15, Volume: 308, Issue:2

    Topics: Animals; Avidin; Biotin; Carrier Proteins; Chromatography, Affinity; Humans; Immunoglobulin G; Indicators and Reagents; Ligands; Protein Binding; Rabbits; Recombinant Proteins; Sepharose; Streptavidin; Tubulin

2002
Biotin synthase of Bacillus subtilis shows less reactivity than that of Escherichia coli in in vitro reaction systems.
    Archives of microbiology, 2002, Volume: 179, Issue:1

    Topics: Bacillus subtilis; Bacterial Proteins; Biotin; Chlorides; Cloning, Molecular; Culture Media; Escherichia coli; Escherichia coli Proteins; Ferric Compounds; In Vitro Techniques; Riboflavin; Species Specificity; Sulfides; Sulfurtransferases

2002
Control of adenosylmethionine-dependent radical generation in biotin synthase: a kinetic and thermodynamic analysis of substrate binding to active and inactive forms of BioB.
    Biochemistry, 2003, Mar-11, Volume: 42, Issue:9

    Topics: Anaerobiosis; Binding Sites; Biotin; Catalysis; Dialysis; Enzyme Activation; Escherichia coli Proteins; Free Radicals; Iron-Sulfur Proteins; Kinetics; Oxidation-Reduction; Protein Conformation; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Substrate Specificity; Sulfurtransferases; Thermodynamics

2003
Diaminobiotin and desthiobiotin have biotin-like activities in Jurkat cells.
    The Journal of nutrition, 2003, Volume: 133, Issue:5

    Topics: Biotin; Carbon-Carbon Ligases; Gene Expression Regulation; Humans; Interleukin-2; Jurkat Cells; Receptors, Interleukin-2

2003
Nutrition and growth of Arthrobotrys conoides.
    Journal of bacteriology, 1962, Volume: 84

    Topics: Animals; Ascomycota; Biotin; Fungi; Glucose; Nematoda; Pyrimidines; Thiamine; Vitamins; Zinc

1962
BIOTIN BIOSYNTHESIS. I. BIOTIN YIELDS AND BIOTIN VITAMERS IN CULTURES OF PHYCOMYCES BLAKESLEEANUS.
    Journal of bacteriology, 1963, Volume: 86

    Topics: Amino Acids; Biological Assay; Biotin; Chromatography; Electrophoresis; Fatty Acids; Fungi; Hydrogen-Ion Concentration; Lactobacillus; Lysine; Neurospora; Phycomyces; Pimelic Acids; Research; Saccharomyces; Trace Elements

1963
STUDIES ON THE FORMATION OF BIOTIN FROM DESTHIOBIOTIN AND SULFATE IN SACCHAROMYCES CEREVISIAE. I. ON BIOTIN FORMATION FROM DESTHIOBIOTIN BY WASHED CELL SUSPENSION OF YEAST.
    The Journal of vitaminology, 1964, Sep-10, Volume: 10

    Topics: Biotin; Cysteine; Glucose; Glutathione; Homocysteine; Metabolism; Methionine; Pharmacology; Research; Saccharomyces; Saccharomyces cerevisiae; Sulfates; Sulfides; Sulfur Oxides; Yeast, Dried

1964
STUDIES ON THE FORMATION OF BIOTIN FROM DESTHIOBIOTIN AND SULFATE IN SACCHAROMYCES CEREVISIAE. II. ON SULFUR SOURCES OF BIOTIN FORMATION BY WASHED CELL SUSPENSION OF YEAST.
    The Journal of vitaminology, 1964, Sep-10, Volume: 10

    Topics: Biotin; Choline; Culture Media; Cysteine; Cystine; Ethionine; Glucose; Glutathione; Homocysteine; Metabolism; Methionine; Research; Saccharomyces; Saccharomyces cerevisiae; Sulfates; Sulfur; Sulfur Oxides; Yeast, Dried

1964
STUDIES ON THE FORMATION OF BIOTIN FROM DESTHIOBIOTIN AND SULFATE IN SACCHAROMYCES CEREVISIAE. 3. ISOTOPIC STUDIES ON BIOTIN FORMATION FROM DESTHIOBIOTIN AND S35-LABELLED SULFATE BY WASHED CELL SUSPENSION OF YEAST.
    The Journal of vitaminology, 1964, Sep-10, Volume: 10

    Topics: Biotin; Chromatography; Culture Media; Cysteine; Cystine; Glucose; Metabolism; Methionine; Neurospora; Research; Saccharomyces; Saccharomyces cerevisiae; Sulfates; Yeast, Dried

1964
THE BIOSYNTHESIS OF BIOTIN IN MICROORGANISMS. 3. THE BIOSYNTHESIS OF (+)-BIOTIN FROM DESTHIOBIOTIN AND ITS CONTROL IN ESCHERICHIA COLI.
    Biochimica et biophysica acta, 1965, Apr-12, Volume: 100

    Topics: Biochemical Phenomena; Biotin; Enzyme Repression; Escherichia coli; Lactobacillus; Metabolism; Research; Saccharomyces

1965
Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme.
    Science (New York, N.Y.), 2004, Jan-02, Volume: 303, Issue:5654

    Topics: Amino Acid Motifs; Binding Sites; Biotin; Catalysis; Crystallization; Crystallography, X-Ray; Dimerization; Escherichia coli; Escherichia coli Proteins; Hydrogen; Hydrogen Bonding; Iron; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; S-Adenosylmethionine; Sulfur; Sulfurtransferases

2004
Role of the [2Fe-2S] cluster in recombinant Escherichia coli biotin synthase.
    Biochemistry, 2004, Feb-24, Volume: 43, Issue:7

    Topics: Anaerobiosis; Biotin; Catalysis; Electron Spin Resonance Spectroscopy; Enzyme Stability; Escherichia coli Proteins; Iron Isotopes; Iron-Sulfur Proteins; Recombinant Proteins; Spectroscopy, Mossbauer; Sulfurtransferases; Time Factors

2004
Development of an enzymatic method for site-specific incorporation of desthiobiotin to recombinant proteins in vitro.
    Analytical biochemistry, 2004, Aug-15, Volume: 331, Issue:2

    Topics: Bacillus subtilis; Base Sequence; Biotin; DNA Primers; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; Hydrogen-Ion Concentration; Mass Spectrometry; Recombinant Proteins

2004
Further investigation on the turnover of Escherichia coli biotin synthase with dethiobiotin and 9-mercaptodethiobiotin as substrates.
    Biochemistry, 2004, Dec-28, Volume: 43, Issue:51

    Topics: Binding Sites; Biotin; Carbon-Sulfur Lyases; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Iron; Kinetics; Sulfurtransferases; Time Factors

2004
Biotin synthase is catalytic in vivo, but catalysis engenders destruction of the protein.
    Chemistry & biology, 2005, Volume: 12, Issue:4

    Topics: Biotin; Blotting, Western; Catalysis; DNA Primers; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Plasmids; Sulfur; Sulfurtransferases

2005
A nucleosidase required for in vivo function of the S-adenosyl-L-methionine radical enzyme, biotin synthase.
    Chemistry & biology, 2005, Volume: 12, Issue:5

    Topics: Biotin; Deoxyadenosines; Escherichia coli; Escherichia coli Proteins; Mutation; N-Glycosyl Hydrolases; Sulfurtransferases

2005
Fluorescence-activated cell sorting and cloning of bona fide CD8+ CTL with reversible MHC-peptide and antibody Fab' conjugates.
    Journal of immunology (Baltimore, Md. : 1950), 2006, Sep-15, Volume: 177, Issue:6

    Topics: Animals; Biotin; Cell Separation; Clone Cells; Flow Cytometry; H-2 Antigens; Histocompatibility Antigens Class I; HLA-A Antigens; HLA-A2 Antigen; Humans; Immunoglobulin Fab Fragments; Mice; Peptides; T-Lymphocytes, Cytotoxic

2006
The ISC [corrected] proteins Isa1 and Isa2 are required for the function but not for the de novo synthesis of the Fe/S clusters of biotin synthase in Saccharomyces cerevisiae.
    Eukaryotic cell, 2007, Volume: 6, Issue:3

    Topics: Biosynthetic Pathways; Biotin; DNA-Binding Proteins; Iron-Sulfur Proteins; Mitochondrial Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sulfurtransferases; Transcription Factors

2007
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.
    Proteomics, 2007, Volume: 7, Issue:23

    Topics: 14-3-3 Proteins; Biotin; Blotting, Western; Cell Line; Chromatography, Affinity; Chromatography, High Pressure Liquid; Humans; MAP Kinase Kinase 1; Multiprotein Complexes; Oligopeptides; Peptides; Proto-Oncogene Proteins B-raf; Tandem Mass Spectrometry; Transfection

2007
In vivo resolution of conflicting in vitro results: synthesis of biotin from dethiobiotin does not require pyridoxal phosphate.
    Chemistry & biology, 2007, Volume: 14, Issue:11

    Topics: Biotin; Escherichia coli; In Vitro Techniques; Pyridoxal Phosphate

2007
A synthesis of dl-dethiobiotin and some related compounds.
    Journal of the Chemical Society, 1948

    Topics: Biotin

1948
Purification of His-tagged proteins with [desthiobiotin-BSA-EDTA] conjugates exhibiting resistance to EDTA.
    Bioconjugate chemistry, 2008, Volume: 19, Issue:3

    Topics: Amino Acid Sequence; Avidin; Biotin; Centrifugation; Chromatography, Agarose; Copper; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Histidine; Metals; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Proteins; Serum Albumin, Bovine; Spectrophotometry, Ultraviolet; Staphylococcal Protein A; Urea

2008
Fluorescence labeling of a cytokine with desthiobiotin-tagged fluorescent puromycin.
    Journal of bioscience and bioengineering, 2008, Volume: 105, Issue:3

    Topics: Animals; Biotin; Cell Line; Fluorescent Dyes; Mice; Puromycin; Thrombopoietin

2008
9-Mercaptodethiobiotin is formed as a competent catalytic intermediate by Escherichia coli biotin synthase.
    Biochemistry, 2008, Sep-02, Volume: 47, Issue:35

    Topics: Biotin; Catalysis; Escherichia coli; Escherichia coli Proteins; Kinetics; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Sulfurtransferases

2008
The synthesis and biological activity of 4-methyl-5-(epsilon-sulfoamyl)-2-imidazolidone, a sulfonic acid analog of desthiobiotin.
    Journal of the American Chemical Society, 1948, Volume: 70, Issue:7

    Topics: Biotin; Imidazoles; Organic Chemicals; Sulfonic Acids

1948
Desthiobiotin and O-heterobiotin as growth factors for normal and degenerate strains of Clostridia.
    Archives of biochemistry, 1948, Volume: 16, Issue:1

    Topics: Bacteria; Biotin; Clostridium; Intercellular Signaling Peptides and Proteins

1948
Selection of smart small-molecule ligands: the proof of principle.
    Analytical chemistry, 2009, Jan-01, Volume: 81, Issue:1

    Topics: Aptamers, Nucleotide; Biotin; Cholesterol; Combinatorial Chemistry Techniques; DNA; Electrophoresis, Capillary; Kinetics; Ligands; Polymerase Chain Reaction

2009
Protein residues that control the reaction trajectory in S-adenosylmethionine radical enzymes: mutagenesis of asparagine 153 and aspartate 155 in Escherichia coli biotin synthase.
    Biochemistry, 2009, Mar-24, Volume: 48, Issue:11

    Topics: Amino Acid Motifs; Asparagine; Aspartic Acid; Biotin; Catalysis; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; S-Adenosylmethionine; Sulfurtransferases

2009
The reaction of aminoesters with ethyl isocyanate; open chain models of desthiobiotin.
    Journal of the American Chemical Society, 1947, Volume: 69, Issue:5

    Topics: Biotin; Humans; Isocyanates

1947
Affinity recovery of lentivirus by diaminopelargonic acid mediated desthiobiotin labelling.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Jul-15, Volume: 878, Issue:22

    Topics: Amino Acids, Diamino; Biotin; Cell Line; Chromatography, Affinity; Genetic Vectors; Humans; Lentivirus; Protein Binding; Streptavidin

2010
Overexpression of biotin synthase and biotin ligase is required for efficient generation of sulfur-35 labeled biotin in E. coli.
    BMC biotechnology, 2010, Oct-11, Volume: 10

    Topics: Acetyl-CoA Carboxylase; Biotin; Biotinylation; Carbon-Nitrogen Ligases; Chromatography, Affinity; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Peptide Fragments; Plasmodium falciparum; Repressor Proteins; Sulfurtransferases

2010
The thiourea analogue of desthiobiotin.
    The Journal of biological chemistry, 1946, Volume: 163

    Topics: Biotin; Humans; Thiourea; Vitamin B Complex; Vitamins

1946
alpha-Isopropyl-5-methyl-2-oxo-4-imidazolidinepropionic acid, a structural isomer of desthiobiotin.
    Journal of the American Chemical Society, 1946, Volume: 68

    Topics: Acids; Biotin; Imidazoles; Organic Chemicals; Oxotremorine; Vitamin B Complex; Vitamins

1946
Studies in the imidazolone series; the synthesis of a lower and a higher homolog of desthiobiotin and of related substances.
    Journal of the American Chemical Society, 1946, Volume: 68, Issue:11

    Topics: Biotin; Imidazoles; Vitamin B Complex; Vitamins

1946
Desthiobiotin in the biosynthesis of biotin.
    The Journal of biological chemistry, 1945, Volume: 160

    Topics: Biotin; Vitamin B Complex; Vitamins

1945
A simple synthesis of dl-desthiobiotin and related substances.
    Journal of the American Chemical Society, 1945, Volume: 67

    Topics: Biotin; Vitamin B Complex; Vitamins

1945
Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding.
    Protein science : a publication of the Protein Society, 2011, Volume: 20, Issue:7

    Topics: Binding Sites; Biotin; Calorimetry; Crystallography, X-Ray; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; Protein Binding; Protein Conformation; Streptavidin; Streptomyces; Surface Plasmon Resonance; Titrimetry

2011
A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.
    Analytical biochemistry, 2011, Sep-01, Volume: 416, Issue:1

    Topics: Bacterial Proteins; Biocatalysis; Biotin; Crystallography, X-Ray; Fluorescence; Fluorescent Dyes; High-Throughput Screening Assays; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; Spectrometry, Fluorescence; Stereoisomerism; Streptavidin; Transaminases

2011
Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis.
    The Plant cell, 2012, Volume: 24, Issue:4

    Topics: Amino Acid Sequence; Amino Acids; Arabidopsis; Arabidopsis Proteins; Biocatalysis; Biosynthetic Pathways; Biotin; Carbon-Nitrogen Ligases; Catalytic Domain; Holoenzymes; Kinetics; Ligands; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Subcellular Fractions; Substrate Specificity; Transaminases

2012
Contamination from an affinity column: an encounter with a new villain in the world of membrane-protein crystallization.
    Acta crystallographica. Section D, Biological crystallography, 2012, Volume: 68, Issue:Pt 10

    Topics: Arabidopsis Proteins; Biotin; Chromatography, Affinity; Crystallization; Crystallography, X-Ray; Membrane Proteins; Protein Binding; Streptavidin

2012
Development of biotin-prototrophic and -hyperauxotrophic Corynebacterium glutamicum strains.
    Applied and environmental microbiology, 2013, Volume: 79, Issue:15

    Topics: Acyl Carrier Protein; Biotin; Coenzyme A; Corynebacterium glutamicum; Escherichia coli; Genetic Engineering; Phototrophic Processes; Pimelic Acids

2013
Profiling protein kinases and other ATP binding proteins in Arabidopsis using Acyl-ATP probes.
    Molecular & cellular proteomics : MCP, 2013, Volume: 12, Issue:9

    Topics: Acylation; Adenosine Triphosphate; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Binding Sites; Biotin; Chaperonin 60; Mass Spectrometry; Molecular Probes; Molecular Sequence Data; Oxidation-Reduction; Peptides; Protein Binding; Protein Kinases; Proteome; Receptors, Cell Surface; Staining and Labeling

2013
An oligofluorene truxene based distributed feedback laser for biosensing applications.
    Biosensors & bioelectronics, 2014, Apr-15, Volume: 54

    Topics: Animals; Avidin; Biosensing Techniques; Biotin; Biotinylation; Cattle; Equipment Design; Fluorenes; Lasers; Semiconductors; Sensitivity and Specificity; Serum Albumin, Bovine

2014
Directed evolution of the substrate specificity of biotin ligase.
    Biotechnology and bioengineering, 2014, Volume: 111, Issue:6

    Topics: Amino Acid Substitution; Biotin; Carbon-Nitrogen Ligases; Directed Molecular Evolution; Escherichia coli; Escherichia coli Proteins; Kinetics; Mutation, Missense; Repressor Proteins; Substrate Specificity

2014
Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.
    Journal of biomolecular screening, 2014, Volume: 19, Issue:6

    Topics: A549 Cells; Adenosine Diphosphate; Adenosine Triphosphate; Apoptosis; Biotin; Cell Survival; Chromatography, Liquid; Drug Discovery; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Mass Spectrometry; NIMA-Related Kinase 1; Peptides; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Serine-Threonine Kinase 3; Viral Load; Virus Replication

2014
Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates.
    Journal of the American Chemical Society, 2014, Feb-26, Volume: 136, Issue:8

    Topics: Antibodies; Biotin; DNA; HeLa Cells; Humans; Ligands; Proteins; Real-Time Polymerase Chain Reaction; Small Molecule Libraries; Streptavidin

2014
Design and selection of a synthetic operon.
    ACS synthetic biology, 2014, Jun-20, Volume: 3, Issue:6

    Topics: Biotin; Cell-Free System; DNA; Gene Expression Regulation; Gene Regulatory Networks; Genes, Synthetic; Operon; Repressor Proteins; Streptavidin; Synthetic Biology; Transcription, Genetic; Translations

2014
Biotin uptake by mouse and human pancreatic beta cells/islets: a regulated, lipopolysaccharide-sensitive carrier-mediated process.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Aug-01, Volume: 307, Issue:3

    Topics: Animals; Biological Transport; Biotin; Cell Line; Humans; Insulin-Secreting Cells; Islets of Langerhans; Kinetics; Lipopolysaccharides; Mice; Pantothenic Acid; RNA Interference; Symporters; Thioctic Acid; Toll-Like Receptor 4; Transfection

2014
Distributed feedback laser for biosensing applications.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2014, Volume: 2014

    Topics: Avidin; Biosensing Techniques; Biotin; Lasers; Peptides; Refractometry; Semiconductors

2014
Secondary anchor targeted cell release.
    Biotechnology and bioengineering, 2015, Volume: 112, Issue:11

    Topics: Animals; Biotin; CD11b Antigen; Cell Line; Cell Separation; Glass; Humans; Immunoglobulin G; Mice; Propylamines; Silanes; Streptavidin

2015
Target Identification in Small Cell Lung Cancer via Integrated Phenotypic Screening and Activity-Based Protein Profiling.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:2

    Topics: Apoptosis; Biomarkers, Tumor; Biotin; Cell Line, Tumor; Cell Survival; Gene Amplification; Humans; Lung Neoplasms; Phenotype; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-myc; Small Cell Lung Carcinoma; Small Molecule Libraries

2016
Impact of the chemicals, essential for the purification process of strict Fe-hydrogenase, on the corrosion of mild steel.
    Bioelectrochemistry (Amsterdam, Netherlands), 2016, Volume: 109

    Topics: Biotin; Clostridium acetobutylicum; Corrosion; Dithionite; Dithiothreitol; Electrochemical Techniques; Equipment Design; Hydrogenase; Iron-Sulfur Proteins; Steel

2016
Near-Infrared Light Activation of Proteins Inside Living Cells Enabled by Carbon Nanotube-Mediated Intracellular Delivery.
    ACS applied materials & interfaces, 2016, Volume: 8, Issue:7

    Topics: Animals; Biotin; Cell Line, Tumor; Cytoplasm; Drug Delivery Systems; Green Fluorescent Proteins; HeLa Cells; Humans; Infrared Rays; Mice; Nanotubes, Carbon; Neoplasms; Proteins; Streptavidin; Xenograft Model Antitumor Assays

2016
Cloning, expression and characterization of histidine-tagged biotin synthase of Mycobacterium tuberculosis.
    Tuberculosis (Edinburgh, Scotland), 2016, Volume: 98

    Topics: Antitubercular Agents; Bacterial Proteins; Biotin; Cloning, Molecular; Cysteine; Deoxyadenosines; Enzyme Inhibitors; Enzyme Stability; Histidine; Hydrogen-Ion Concentration; Kinetics; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Protein Engineering; Protein Multimerization; Recombinant Fusion Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Sulfurtransferases; Temperature

2016
Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96.
    Journal of immunology (Baltimore, Md. : 1950), 2016, 06-15, Volume: 196, Issue:12

    Topics: Adenosine Triphosphate; Animals; Antigens, Neoplasm; Biotin; Cell Line; Cyclooxygenase 2; Endoplasmic Reticulum; Enterocytes; HEK293 Cells; Humans; Hydrazones; Interleukin-1beta; Intestines; Lipopolysaccharides; Mass Spectrometry; Myeloid Differentiation Factor 88; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Rats; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptor 9

2016
Quantitative Secretome Analysis of Activated Jurkat Cells Using Click Chemistry-Based Enrichment of Secreted Glycoproteins.
    Journal of proteome research, 2017, 01-06, Volume: 16, Issue:1

    Topics: Biotin; Chromatography, Affinity; Click Chemistry; Culture Media, Conditioned; Gene Expression; Gene Ontology; Glycoproteins; Humans; Jurkat Cells; Lymphocyte Activation; Molecular Sequence Annotation; Protein Biosynthesis; Proteome; Staining and Labeling; Tetradecanoylphorbol Acetate

2017
Regenerative biosensor for use with biotinylated bait molecules.
    Biosensors & bioelectronics, 2018, Jan-15, Volume: 99

    Topics: Biosensing Techniques; Biotin; Biotinylation; Guanidines; Indicators and Reagents; Microfluidic Analytical Techniques; Oligonucleotide Array Sequence Analysis; Protein Binding; Streptavidin; Surface Plasmon Resonance; Thiocyanates

2018
Ribonucleoprotein purification and characterization using RNA Mango.
    RNA (New York, N.Y.), 2017, Volume: 23, Issue:10

    Topics: Aptamers, Nucleotide; Benzothiazoles; Biochemistry; Biotin; Green Fluorescent Proteins; Quinolines; Ribonucleoproteins; RNA, Bacterial; RNA, Small Nuclear; RNA, Untranslated; Saccharomyces cerevisiae; Spectrometry, Fluorescence

2017
Competitive Affinity Release for Long-Term Delivery of Antibodies from Hydrogels.
    Angewandte Chemie (International ed. in English), 2018, 03-19, Volume: 57, Issue:13

    Topics: Antibodies; Biotin; Delayed-Action Preparations; Drug Carriers; Humans; Hydrogels; Sepharose; Streptavidin

2018
Hydrogels with reversible chemical environments for in vitro cell culture.
    Biomedical materials (Bristol, England), 2018, 04-11, Volume: 13, Issue:4

    Topics: Alginates; Biotin; Cell Culture Techniques; Cell Differentiation; Cell Movement; Cell Proliferation; Culture Media; Fluorescent Dyes; Human Umbilical Vein Endothelial Cells; Humans; Hydrogels; Oligopeptides; Peptides; Sepharose; Streptavidin

2018
Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells.
    Journal of visualized experiments : JoVE, 2018, 04-25, Issue:134

    Topics: Biotin; Mesothelioma; Proteins; RNA; Streptavidin

2018
EPR-Derived Structure of a Paramagnetic Intermediate Generated by Biotin Synthase BioB.
    Journal of the American Chemical Society, 2018, 10-10, Volume: 140, Issue:40

    Topics: Biotin; Electron Spin Resonance Spectroscopy; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Protein Conformation; Sulfurtransferases

2018
Pull-Down of Metalloproteins in Their Native States by Using Desthiobiotin-Based Probes.
    Chembiochem : a European journal of chemical biology, 2019, 04-15, Volume: 20, Issue:8

    Topics: Biotin; Carbonic Anhydrases; Humans; Metalloproteins; Molecular Probes; Protein Conformation; Sulfonamides

2019
    Theranostics, 2018, Volume: 8, Issue:20

    Topics: Animals; Antineoplastic Agents; Biotin; Combined Modality Therapy; Disease Models, Animal; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Therapy; Genetic Therapy; HeLa Cells; Humans; Hyperthermia, Induced; Mice, Nude; Molecular Targeted Therapy; Nanoparticles; Neoplasms; Oligonucleotides, Antisense; Phototherapy; Radiotherapy, Image-Guided; Theranostic Nanomedicine; Treatment Outcome

2018
Development of a Method To Prioritize Protein-Ligand Pairs on Beads Using Protein Conjugated to a Near-IR Dye.
    ACS combinatorial science, 2019, 03-11, Volume: 21, Issue:3

    Topics: Antibodies; Biotin; Carbonic Anhydrases; Combinatorial Chemistry Techniques; Fluorescent Dyes; High-Throughput Screening Assays; Infrared Rays; Ligands; Limit of Detection; Peptide Library; Spectrometry, Fluorescence; Streptavidin

2019
Synthesis of d-desthiobiotin-AI-2 as a novel chemical probe for autoinducer-2 quorum sensing receptors.
    Bioorganic chemistry, 2019, Volume: 92

    Topics: Alkynes; Biotin; Carrier Proteins; Escherichia coli; Escherichia coli Proteins; Homoserine; Lactones; Ligands; Molecular Structure; Quorum Sensing; Signal Transduction

2019
A Synthetic Vesicle-to-Vesicle Communication System.
    Journal of the American Chemical Society, 2019, 11-06, Volume: 141, Issue:44

    Topics: Artificial Cells; Avidin; Biotin; Lipid Bilayers; Liposomes; Phosphatidylcholines; Phosphatidylethanolamines; Signal Transduction

2019
Functional annotation of serine hydrolases in the asexual erythrocytic stage of Plasmodium falciparum.
    Scientific reports, 2019, 11-26, Volume: 9, Issue:1

    Topics: Biotin; Erythrocytes; Humans; Hydrolases; Life Cycle Stages; Lipolysis; Plasmodium falciparum; Proteomics; Protozoan Proteins; Serine

2019
Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome.
    Angewandte Chemie (International ed. in English), 2020, 02-10, Volume: 59, Issue:7

    Topics: Azides; Biotin; Cysteine; Isotope Labeling; Molecular Structure; Staphylococcus aureus

2020
Covalent Immune Recruiters: Tools to Gain Chemical Control Over Immune Recognition.
    ACS chemical biology, 2020, 04-17, Volume: 15, Issue:4

    Topics: Animals; Antigens, Surface; Biotin; Glutamate Carboxypeptidase II; HEK293 Cells; Humans; Imidazoles; Immunoglobulin G; Mice; Molecular Docking Simulation; Molecular Probes; Phagocytosis; Protein Binding; Receptors, Immunologic; Streptavidin; Urea

2020
Improved biotin, thiamine, and lipoic acid biosynthesis by engineering the global regulator IscR.
    Metabolic engineering, 2020, Volume: 60

    Topics: Biotin; Escherichia coli; Escherichia coli Proteins; Fermentation; Iron-Sulfur Proteins; Metabolic Engineering; Models, Molecular; Proteomics; Sulfurtransferases; Thiamine; Thioctic Acid; Transcription Factors

2020
Chemical Proteomic Profiling of the Interacting Proteins of Isoprenoid Pyrophosphates.
    Analytical chemistry, 2020, 06-16, Volume: 92, Issue:12

    Topics: Biotin; Histone Deacetylase 1; Humans; Molecular Structure; Polyisoprenyl Phosphates; Proteomics

2020
Active cargo loading into extracellular vesicles: Highlights the heterogeneous encapsulation behaviour.
    Journal of extracellular vesicles, 2021, Volume: 10, Issue:13

    Topics: Animals; Biotin; Capsules; Caseins; Cell Survival; Doxorubicin; Drug Compounding; Drug Delivery Systems; Drug Liberation; Extracellular Vesicles; Hep G2 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Liposomes; Milk; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Sonication

2021
The overlooked role of a biotin precursor for marine bacteria - desthiobiotin as an escape route for biotin auxotrophy.
    The ISME journal, 2022, Volume: 16, Issue:11

    Topics: Bacteria; Biotin; Ecosystem; Micronutrients; Phylogeny; Vitamins

2022