atropine has been researched along with sarin in 91 studies
| Studies (atropine) | Trials (atropine) | Recent Studies (post-2010) (atropine) | Studies (sarin) | Trials (sarin) | Recent Studies (post-2010) (sarin) |
|---|---|---|---|---|---|
| 26,711 | 1,259 | 1,697 | 963 | 6 | 270 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (39.56) | 18.7374 |
| 1990's | 19 (20.88) | 18.2507 |
| 2000's | 13 (14.29) | 29.6817 |
| 2010's | 20 (21.98) | 24.3611 |
| 2020's | 3 (3.30) | 2.80 |
| Authors | Studies |
|---|---|
| Green, DM; Inch, TD; Muir, AW; Stratton, JA | 1 |
| Gordon, JJ; Leadbeater, L | 1 |
| Hauser, W; Weger, N | 1 |
| Bosković, B | 1 |
| Fiscus, RR; Karczmar, AG; Van Meter, WG | 1 |
| Bajgar, J; Hrdina, V; Jakl, A; Patocka, J | 1 |
| Dettbarn, WD; Gupta, RC | 1 |
| Anderson, DR; Harris, LW; Koplovitz, I; Lennox, WJ; Stewart, JR | 1 |
| Fiekers, JF; Heppner, TJ | 1 |
| Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG | 1 |
| Liu, WF | 1 |
| Alioth-Streichenberg, CM; Bodmer, DM; Waser, PG | 1 |
| Anzueto, A; deLemos, RA; Hamil, H; Jenkinson, SG; Johnson, D; Moore, G; Seidenfeld, J | 1 |
| Bass, KN; Das Gupta, S; Warnick, JE | 1 |
| Das Gupta, S; Deshpande, SB; Warnick, JE | 1 |
| Albuquerque, EX; Aracava, Y; Boyne, AF; Deshpande, SS; Idriss, M; Kawabuchi, M; Rickett, DL | 1 |
| Albuquerque, EX; Deshpande, SS; Kauffman, FC; Rickett, DL; Viana, GB | 1 |
| Fernando, JC; Ho, IK; Hoskins, B | 1 |
| Berman, HA; Edery, H | 1 |
| Inns, RH; Leadbeater, L; Rylands, JM | 1 |
| Heath, C; Preston, E | 1 |
| Davies, DR; Holland, P | 1 |
| Aghajanian, GK; Crowell, EB; Hayes, AH; Ketchum, JS; Sidell, FR | 1 |
| Baigar, J; Girdiná, V; Yákl, A | 1 |
| Crone, HD | 1 |
| Sidell, FR | 1 |
| Bajgar, J; Hrdina, V; Jakl, A | 1 |
| Clement, JG; Copeman, HT | 1 |
| Lundy, PM; Shih, TM | 1 |
| Clement, JG; Filbert, M | 1 |
| Szinicz, L; Worek, F | 1 |
| Aikawa, N; Nozaki, H | 1 |
| Kirchner, T; Szinicz, L; Worek, F | 1 |
| Clement, JG | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Das Gupta, S; Deshpande, SB; Warnick, JE; Yang, QZ | 1 |
| Das Gupta, S; Pant, SC; Vijayaraghavan, R | 1 |
| Aikawa, N; Fujishima, S; Hori, S; Kimura, H; Nozaki, H; Ohki, T; Sagoh, M; Shinozawa, Y; Suzuki, M; Takuma, K | 1 |
| Kulling, P; Persson, SA | 1 |
| Liang, J; Luo, C | 1 |
| Bégos, A; Bizot, JC; Breton, P; Brochet, D; Tambuté, A; Trovero, F | 1 |
| McDonough, JH; Shih, TM | 1 |
| Benschop, HP; Helmich, RB; Langenberg, JP; Spruit, HE; Trap, HC; van der Wiel, HJ; van Helden, HP | 1 |
| Kassa, J; Krejcová, G; Vachek, J | 2 |
| Rotenberg, JS | 1 |
| Breton, P; Buée, J; Calvet, JH; Christin, D; Delamanche, S; Taysse, L | 1 |
| ASKEW, BM | 1 |
| DECANDOLE, CA; McPHAIL, MK | 1 |
| DAVIES, DR; GREEN, AL; WILLEY, GL | 1 |
| STEWART, WC | 1 |
| COLEMAN, IW; GRANT, GA; LITTLE, PE | 1 |
| BROWN, RV | 1 |
| COLBOURN, JL; CROOK, JW; GOODMAN, AI; OBERST, FW; WILLS, JH; ZVIRBLIS, P | 1 |
| WILLS, JH | 1 |
| LOOMIS, TA; SALAFSKY, B | 1 |
| ADIE, PA; FUKUYAMA, GS; HUGHES, ER | 1 |
| BANNARD, RA; COLEMAN, IW; LITTLE, PE | 1 |
| HEILBRONN, E; TOLAGEN, B | 1 |
| CROOK, JW; KOON, WS; OBERST, FW | 1 |
| Newmark, J | 1 |
| Dabisch, PA; Miller, DB; Mioduszewski, RJ; Reutter, SA; Thomson, SA | 1 |
| Allon, N; Grauer, E; Manistersky, E; Rabinovitz, I; Weissman, BA | 1 |
| Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Hamilton, TA; Kan, RK; Oliveira, M; Pereira, EF; Randall, WR; Romano, JA | 1 |
| Kellar, KJ | 1 |
| Hrobak, PK | 1 |
| Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F | 1 |
| McDonough, JH; O'Donnell, JC; Shih, TM; Skovira, JW | 1 |
| Akkerman, M; Albuquerque, EX; Alkondon, M; Aracava, Y; Merchenthaler, I; Pereira, EF | 1 |
| Cui, W; Ge, X; Luo, W; Wang, H | 1 |
| Doctor, BP; Marshall, S; Morthole, V; Nambiar, MP; Oguntayo, S; Perkins, MW; Pierre, Z; Rezk, P; Sciuto, AM; Song, J | 1 |
| Dillman, JF; Lumley, LA; Meyerhoff, JL; Robison, CL; Spradling, KD | 2 |
| Kassa, J; Kunesova, G | 1 |
| Karasova, JZ; Kassa, J; Misik, J | 1 |
| Arima, Y; Itoh, T; Maeno, Y; Makita, R; Nagao, M; Namera, A; Shiraishi, H; Torikoshi, A; Watanabe, Y; Yoshizumi, M | 1 |
| Gulland, A | 1 |
| Kehe, K; Thiermann, H; Worek, F | 1 |
| Eisenkraft, A; Kassirer, M; Kreiss, Y; Milk, N; Ophir, N; Rosman, Y; Shiyovich, A; Shrot, S | 1 |
| Horova, A; Kassa, J; Matouskova, L; Musilek, K; Sepsova, V | 1 |
| Bloch-Shilderman, E; Brandeis, R; Egoz, I; Gore, A; Grauer, E; Nili, U; Turetz, J | 1 |
| Buchanan, S; Dippenaar, N; Laher, AE; Simo, NCT; Watermeyer, MJ | 1 |
| Egoz, I; Gore, A; Grauer, E; Nili, U | 1 |
| Chapman, S; Gez, R; Lazar, S; Pittel, Z | 1 |
| Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL | 1 |
| Cochrane, L; Cornelissen, AS; Joosen, MJA; Klaassen, SD; Shearer, JD; Skiadopoulos, MH; van Groningen, T; Verheij, E | 1 |
| Chapman, S; Egoz, I; Gez, R; Grauer, E; Lazar, S | 1 |
| Bohnert, S; Cornelissen, AS; Joosen, MJA; Klaassen, SD; van Groningen, T | 1 |
| Gore, A | 1 |
| Huang, C; Liu, J; Wang, Y; Yang, Y; Zhang, L; Zhao, D; Zhong, Y; Zhou, Y | 1 |
3 review(s) available for atropine and sarin
| Article | Year |
|---|---|
Therapy for nerve agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman | 2004 |
Limitations and challenges in treatment of acute chemical warfare agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Mustard Gas; Organothiophosphorus Compounds; Oximes; Sarin | 2013 |
Broad Spectrum Treatment for Ocular Insult Induced by Organophosphate Chemical Warfare Agents.
Topics: Animals; Atropine; Chemical Warfare Agents; Eye; Nerve Agents; Organophosphate Poisoning; Organophosphates; Sarin | 2020 |
1 trial(s) available for atropine and sarin
| Article | Year |
|---|---|
Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates.
Topics: Adult; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Cyanosis; Depression; Electrocardiography; Epistaxis; Humans; Insecticides; Male; Mental Disorders; Middle Aged; Placebos; Pralidoxime Compounds; Pyridinium Compounds; Respiration; Sarin; Scopolamine; Soman; Sulfisoxazole; Tachycardia; Time Factors | 1974 |
87 other study(ies) available for atropine and sarin
| Article | Year |
|---|---|
Dual mechanism of the antidotal action of atropine-like drugs in poisoning by organophosphorus anticholinesterases.
Topics: Animals; Anticonvulsants; Antidotes; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Mice; Mydriatics; Nicotine; Organophosphate Poisoning; Parasympatholytics; Pentylenetetrazole; Rats; Sarin; Stereoisomerism; Time Factors | 1977 |
The prophylactic use of l-methyl, 2-hydroxyiminomethylpyridinium methanesulfonate (P2S) in the treatment of organophosphate poisoning.
Topics: Animals; Atropine; Drug Therapy, Combination; Female; Guinea Pigs; Lethal Dose 50; Mesylates; Organophosphate Poisoning; Pralidoxime Compounds; Rabbits; Sarin; Soman; Time Factors | 1977 |
Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs.
Topics: Animals; Antidotes; Aspartate Aminotransferases; Atropine; Benactyzine; Cholinesterase Inhibitors; Cholinesterases; Creatine Kinase; Dogs; Lethal Dose 50; Male; Organothiophosphorus Compounds; Pyridinium Compounds; Sarin; Soman | 1979 |
The influence of 2-/o-cresyl/-4 H-1 : 3 : 2-benzodioxa-phosphorin-2-oxide (CBDP) on organophosphate poisoning and its therapy.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cyclic P-Oxides; Drug Interactions; Liver; Male; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Sarin; Soman; Structure-Activity Relationship | 1979 |
CNS effects of anticholinesterases in the presence of inhibited cholinesterases.
Topics: Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterases; Electroencephalography; Electrophysiology; Isoflurophate; Male; Physostigmine; Rabbits; Sarin | 1978 |
Antidotal therapy and changes of acetylcholinesterase activity following isopropyl methylphosphonofluoridate intoxication in mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Sarin; Trimedoxime | 1975 |
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine | 1992 |
Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents.
Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin | 1992 |
The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Sympathetic; Organothiophosphorus Compounds; Rana catesbeiana; Sarin; Soman; Synaptic Transmission | 1991 |
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl | 1991 |
A symptomatological assessment of organophosphate-induced lethality in mice: comparison of atropine and clonidine protection.
Topics: Animals; Atropine; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphorus Compounds; Poisoning; Sarin | 1991 |
Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Female; Obidoxime Chloride; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Sarin | 1991 |
Acute inhalation toxicity of soman and sarin in baboons.
Topics: Administration, Inhalation; Airway Resistance; Animals; Apnea; Arrhythmias, Cardiac; Atropine; Blood Pressure; Bronchoalveolar Lavage Fluid; Diaphragm; Heart Block; Hemodynamics; Hypoxia; Injections, Intravenous; Lung; Neutrophils; Organophosphorus Compounds; Papio; Respiration; Sarin; Soman | 1990 |
Interaction of reversible and irreversible cholinesterase inhibitors on the monosynaptic reflex in neonatal rats.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Physostigmine; Pregnancy; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Reflex, Monosynaptic; Sarin; Spinal Cord | 1989 |
Segmental synaptic depression caused by diisopropylphosphorofluoridate and sarin is reversed by thyrotropin-releasing hormone in the neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Atropine; Cholinesterases; Isoflurophate; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Reflex, Monosynaptic; Sarin; Spinal Cord; Thyrotropin-Releasing Hormone | 1988 |
Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Female; Ganglionic Blockers; Grasshoppers; In Vitro Techniques; Muscle Contraction; Organophosphate Poisoning; Organothiophosphorus Compounds; Physostigmine; Rana pipiens; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Sarin; Synapses | 1985 |
Effectiveness of physostigmine as a pretreatment drug for protection of rats from organophosphate poisoning.
Topics: Acetylcholinesterase; Action Potentials; Animals; Atropine; Body Weight; Brain; Brain Chemistry; Cholinesterases; Female; gamma-Aminobutyric Acid; Muscle Contraction; Muscles; Neostigmine; Organophosphate Poisoning; Physostigmine; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Sarin | 1986 |
Hypersensitivity to antimuscarinic agents following brief exposure to Soman and Sarin.
Topics: Animals; Atropine; Atropine Derivatives; Drug Hypersensitivity; Male; Organophosphorus Compounds; Parasympatholytics; Rats; Rats, Inbred Strains; Sarin; Soman; Stereotyped Behavior; Tremor | 1986 |
Yohimbine antagonism of the vasodepression elicited by organophosphates applied on ventral medulla oblongata.
Topics: Animals; Atropine; Blood Pressure; Cats; Cholinesterase Inhibitors; Electrocardiography; Female; Injections, Intraventricular; Male; Medulla Oblongata; Norepinephrine; Organophosphorus Compounds; Respiration; Sarin; Soman; Yohimbine | 1985 |
Treatment of poisoning by soman.
Topics: Animals; Antidotes; Atropine; Carbamates; Diazepam; Guinea Pigs; Male; Motor Activity; Organophosphate Poisoning; Parasympatholytics; Phenylpropionates; Physostigmine; Pyridostigmine Bromide; Sarin; Soman; Time Factors | 1985 |
Atropine-insensitive vasodilatation and hypotension in the organophosphate-poisoned rabbit.
Topics: Animals; Atropine; Blood Pressure; Blood Vessels; Cholinesterase Inhibitors; Forelimb; Heart Rate; Hypotension; Isoflurophate; Organophosphate Poisoning; Rabbits; Respiration, Artificial; Sarin; Soman; Vascular Resistance; Vasodilator Agents | 1972 |
Effect of oximes and atropine upon the development of delayed neurotoxic signs in chickens following poisoning by DFP and sarin.
Topics: Animals; Atropine; Chickens; Cholinesterase Inhibitors; Isoflurophate; Lethal Dose 50; Neurons; Organophosphorus Compounds; Oximes; Sarin; Time Factors | 1972 |
Atropine, scopolamine, and ditran: comparative pharmacology and antagonists in man.
Topics: Acridines; Adult; Atropine; Behavior; Blood Pressure; Central Nervous System; Delirium; Glycolates; Heart Rate; Human Experimentation; Humans; Isoflurophate; Male; Memory; Methylphenidate; Neostigmine; Parasympatholytics; Physostigmine; Piperidines; Respiration; Sarin; Scopolamine | 1973 |
[Therapeutic action of some pyridine series dioximes in experimental O-isopropyl-methyl-fluorophosphonate poisoning].
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Drug Combinations; Male; Mice; Organophosphate Poisoning; Oximes; Pyridines; Sarin | 1973 |
Can allosteric effectors of acetylcholinesterase control the rate of ageing of the phosphonylated enzyme?
Topics: Acetylcholinesterase; Allyl Compounds; Animals; Atropine; Cattle; Coumarins; Erythrocytes; Gallamine Triethiodide; Rabbits; Sarin; Toxiferine; Tropanes; Tubocurarine | 1974 |
The influence of obidoxime on acetylcholinesterase activity in different parts of the mouse brain following isopropylmethyl phosphonofluoridate intoxication.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Diencephalon; Dose-Response Relationship, Drug; Male; Medulla Oblongata; Mesencephalon; Mice; Organophosphate Poisoning; Pons; Pyridinium Compounds; Sarin | 1972 |
Soman and sarin induce a long-lasting naloxone-reversible analgesia in mice.
Topics: Analgesics; Animals; Atropine; Dose-Response Relationship, Drug; Hot Temperature; Male; Mice; Naloxone; Organophosphorus Compounds; Reaction Time; Sarin; Soman | 1984 |
Examination of the role of central cholinergic mechanisms in the therapeutic effects of HI-6 in organophosphate poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Injections, Intraventricular; Lethal Dose 50; Male; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1983 |
Antidote effect of sodium fluoride against organophosphate poisoning in mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carboxylesterase; Carboxylic Ester Hydrolases; Drug Interactions; Fluorides; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Sarin; Sodium Fluoride; Soman | 1983 |
Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Drug Synergism; Female; Guinea Pigs; Heart Function Tests; Organothiophosphorus Compounds; Oximes; Pyridostigmine Bromide; Respiration; Respiratory Function Tests; Sarin | 1995 |
Treatment of nerve gas poisoning.
Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman | 1995 |
Sarin poisoning in Tokyo subway.
Topics: Atropine; Female; Humans; Male; Middle Aged; Miosis; Sarin; Vision Disorders | 1995 |
Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Blood Pressure; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Guinea Pigs; Heart Rate; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration; Sarin | 1995 |
Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Drug Synergism; Injections, Subcutaneous; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Poisoning; Sarin | 1994 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Biphasic action of sarin on monosynaptic reflex in the neonatal rat spinal cord in vitro.
Topics: Animals; Animals, Newborn; Atropine; Electric Stimulation; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Nicotinic Antagonists; Parasympatholytics; Pregnancy; Rats; Rats, Wistar; Reflex, Monosynaptic; Sarin; Spinal Cord | 1993 |
Sarin induced lung pathology and protection by standard therapy regime.
Topics: Animals; Atropine; Cholinesterase Reactivators; Diazepam; Environmental Exposure; Lung; Male; Pralidoxime Compounds; Rats; Sarin | 1993 |
Secondary exposure of medical staff to sarin vapor in the emergency room.
Topics: Adult; Atropine; Disasters; Emergency Medical Services; Female; Humans; Japan; Male; Medical Staff, Hospital; Middle Aged; Muscarinic Antagonists; Occupational Exposure; Retrospective Studies; Sarin; Violence; Vision Disorders | 1995 |
[The nerve gas terrorist attack in Tokyo subway 1995. Cooperation during the relief work is necessary].
Topics: Atropine; Disaster Planning; Gas Poisoning; Humans; Parasympatholytics; Pralidoxime Compounds; Railroads; Sarin; Tokyo; Violence | 1997 |
Evaluation of combined toxic effects of GB/GF and efficacy of jielin injection against combined poisoning in mice.
Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Humans; Injections; Male; Mice; Organophosphorus Compounds; Pralidoxime Compounds; Sarin; Software | 1997 |
Pharmacological profile of CEB-1957 and atropine toward brain muscarinic receptors and comparative study of their efficacy against sarin poisoning.
Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Brain; Cholinesterase Inhibitors; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Poisoning; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Sarin; Thiophenes | 1998 |
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication.
Topics: Animals; Anticonvulsants; Atropine; Biperiden; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Seizures; Soman | 2000 |
Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs.
Topics: Acetylcholinesterase; Administration, Inhalation; Animals; Area Under Curve; Atropine; Chemical Warfare Agents; Guinea Pigs; Injections, Intravenous; Male; Sarin; Stereoisomerism | 2000 |
Effect of atropine and the oxime HI-6 on low-level sarin-induced alteration of performance of rats in a T-maze.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Maze Learning; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin | 2002 |
The impairment of spatial memory following low-level sarin inhalation exposure and antidotal treatment in rats.
Topics: Administration, Inhalation; Animals; Antidotes; Atropine; Male; Maze Learning; Memory; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin | 2002 |
Diagnosis and management of nerve agent exposure.
Topics: Antidotes; Atropine; Benzodiazepines; Bioterrorism; Chemical Warfare Agents; Child; Environmental Exposure; Humans; Organophosphate Poisoning; Resuscitation; Sarin; Triage | 2003 |
Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose.
Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Interactions; Electroencephalography; Guinea Pigs; Histocytochemistry; Muscarinic Antagonists; Nervous System Diseases; Pralidoxime Compounds; Prodrugs; Pyridostigmine Bromide; Respiratory Insufficiency; Sarin; Seizures | 2003 |
Oximes and atropine in sarin poisoning.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diacetyl; Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Hydroxylamines; Mice; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Rats; Sarin | 1957 |
Sarin and paraoxon antagonism in different.
Topics: Atropine; Autonomic Agents; Bis-Trimethylammonium Compounds; Cholinesterase Inhibitors; Humans; Paraoxon; Parathion; Phosphates; Sarin | 1957 |
2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning.
Topics: Animals; Atropine; Diphosphates; Humans; Insecticides; Male; Mesylates; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Pyrans; Pyridinium Compounds; Sarin | 1959 |
The effects of sarin and atropine on the respiratory center and neuromuscular junctions of the rat.
Topics: Animals; Atropine; Cell Respiration; Cholinesterase Inhibitors; Neuromuscular Junction; Phosphates; Rats; Respiration; Respiratory Center; Sarin | 1959 |
Oxime mixtures and atropine in the protection of mice and rats from sarin poisoning.
Topics: Animals; Atropine; Hydroxylamines; Mice; Oximes; Phosphates; Rats; Sarin | 1960 |
The effects of intracisternal sarin and pyridine-2-aldoxime methyl methanesulphonate in anesthetized dogs.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Methyl Methanesulfonate; Oximes; Phosphates; Pyridines; Sarin | 1960 |
Adjunctive value of oral prophylaxis with the oximes 2-PAM lactate and 2-PAM methanesulfonate to therapeutic administration of atropine in dogs poisoned by inhaled Sarin vapor.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Lactic Acid; Mesylates; Oximes; Phosphates; Pralidoxime Compounds; Pyridines; Sarin | 1962 |
Anticholinergic compounds as a adjuncts to atropine in preventing lethality by Sarin in the rabbit.
Topics: Animals; Atropine; Cholinergic Antagonists; Parasympatholytics; Phosphates; Rabbits; Sarin | 1961 |
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION.
Topics: Atropine; Cholinesterase Inhibitors; Enzyme Inhibitors; Mice; Neostigmine; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pharmacology; Phosphorus; Poisons; Pralidoxime Compounds; Pyridines; Rats; Research; Sarin; Soman; Toxicology | 1963 |
INCREASED CONCENTRATIONS OF BLOOD LIPIDS IN GUINEA PIGS POISONED BY SARIN.
Topics: Atropine; Blood Chemical Analysis; Guinea Pigs; Hyperlipidemias; Lipids; Muscle Spasticity; Organophosphate Poisoning; Oximes; Paralysis; Phosphorus; Poisons; Research; Sarin; Toxicology | 1963 |
CHOLINOLYTICS IN THE TREATMENT OF ANTICHOLINESTERASE POISONING. III. THE EFFECTS OF QUATERNIZATION AND ALTERATION OF ANIONIC FUNCTION OF THE POTENCY OF CHOLINOLYTICS IN THE TREATMENT OF SARIN POISONING.
Topics: Absorption; Ammonium Compounds; Atropine; Autonomic Agents; Blood Chemical Analysis; Cholinergic Antagonists; Cholinesterase Inhibitors; Mice; Organophosphate Poisoning; Oximes; Parasympatholytics; Phosphorus; Poisons; Quaternary Ammonium Compounds; Research; Sarin; Therapeutics; Toxicology | 1963 |
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONING.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pharmacology; Phosphates; Research; Sarin; Soman; Toxicology | 1965 |
The effectiveness of 2-PAM and TMB-4 as adjuncts to atropine therapy in dogs exposed to Sarin vapor by inhalation.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Phosphates; Pralidoxime Compounds; Pyridines; Sarin; Trimedoxime | 1962 |
Miotic tolerance to sarin vapor exposure: role of the sympathetic and parasympathetic nervous systems.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Cholinesterase Inhibitors; Gases; Infrared Rays; Male; Miosis; Parasympathetic Nervous System; Parasympatholytics; Phentolamine; Pupil; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sarin; Sympathetic Nervous System | 2005 |
Acute and long-lasting cardiac changes following a single whole-body exposure to sarin vapor in rats.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Behavior, Animal; Blood Pressure; Chemical Warfare Agents; Cholinesterase Inhibitors; Electrocardiography; Epinephrine; Heart; Inhalation Exposure; Lethal Dose 50; Long QT Syndrome; Male; Muscarinic Antagonists; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sarin; Scopolamine; Spectroscopy, Fourier Transform Infrared; Vasoconstrictor Agents | 2005 |
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Lethal Dose 50; Neurons; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Poisoning; Pyridostigmine Bromide; Sarin; Sesquiterpenes; Soman; Time Factors | 2006 |
Overcoming inhibitions.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Neurons; Neurotransmitter Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Paraoxon; Pralidoxime Compounds; Pyridostigmine Bromide; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Seizures; Soman; Time Factors | 2006 |
Nerve agents: implications for anesthesia providers.
Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors | 2008 |
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2008 |
Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diacetyl; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Guinea Pigs; Injections, Intramuscular; Male; Muscarinic Antagonists; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Sarin; Seizures; Treatment Outcome; Up-Regulation | 2010 |
Molecular and cellular actions of galantamine: clinical implications for treatment of organophosphorus poisoning.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinergic Fibers; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Interactions; Female; Galantamine; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Nerve Degeneration; Organ Culture Techniques; Organophosphate Poisoning; Organophosphorus Compounds; Sarin; Soman; Treatment Outcome | 2010 |
Targeting cholinesterase inhibitor poisoning with a novel blocker against both nicotinic and muscarinic receptors.
Topics: Animals; Atropine; Benzilates; Cell Line; Cholinergic Antagonists; Cholinesterase Inhibitors; Guinea Pigs; Membrane Potentials; Mice; Organothiophosphorus Compounds; Patch-Clamp Techniques; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Receptors, Nicotinic; Sarin | 2010 |
Endotracheal aerosolization of atropine sulfate protects against soman-induced acute respiratory toxicity in guinea pigs.
Topics: Acetylcholinesterase; Administration, Inhalation; Animals; Atropine; Body Weight; Bronchoalveolar Lavage Fluid; Butyrylcholinesterase; Chemical Warfare Agents; Guinea Pigs; Heart Rate; Inhalation Exposure; Lethal Dose 50; Lung; Male; Plethysmography, Whole Body; Respiratory Tract Diseases; Sarin; Soman; Tidal Volume; Trachea | 2011 |
Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures.
Topics: Animals; Anticonvulsants; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Male; Microarray Analysis; Muscarinic Antagonists; Pralidoxime Compounds; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Signal Transduction; Transcription, Genetic | 2011 |
Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin.
Topics: Amygdala; Animals; Anticonvulsants; Atropine; Cerebral Cortex; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Gene Expression Profiling; Gene Regulatory Networks; Hippocampus; Interleukin-1beta; Interleukin-6; Male; Microarray Analysis; Muscarinic Antagonists; Oximes; Principal Component Analysis; Pyridines; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Septum of Brain; Thalamus; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2011 |
The benefit of combination of oximes for the neuroprotective efficacy of antidotal treatment of sarin-poisoned rats.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Molecular Structure; Neuroprotective Agents; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Trimedoxime | 2012 |
A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.
Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Czech Republic; Drug Therapy, Combination; Lethal Dose 50; Male; Muscarinic Antagonists; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Psychomotor Performance; Pyridinium Compounds; Rats; Rats, Wistar; Sarin | 2012 |
Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Atropine; Blood Pressure; Chemical Warfare Agents; Diphosphonates; Heart Rate; Hemodynamics; Male; Muscarinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Respiration, Artificial; Sarin | 2013 |
Lack of atropine in Syria hampers treatment after gas attacks.
Topics: Atropine; Chemical Warfare Agents; Humans; Muscarinic Antagonists; Poisoning; Sarin; Syria | 2013 |
Lessons learned from the Syrian sarin attack: evaluation of a clinical syndrome through social media.
Topics: Atropine; Chemical Terrorism; Child; Cholinergic Antagonists; Decontamination; Disaster Planning; Female; Humans; Infant; Injections, Intravenous; Male; Mass Casualty Incidents; Poisoning; Sarin; Social Media; Syria | 2014 |
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.
Topics: Acetylcholinesterase; Animals; Animals, Outbred Strains; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats, Wistar; Sarin | 2015 |
Synergism Between Anticholinergic and Oxime Treatments Against Sarin-Induced Ocular Insult in Rats.
Topics: Administration, Ophthalmic; Animals; Atropine; Cholinesterase Reactivators; Drug Synergism; Eye; Male; Miosis; Oximes; Rats; Rats, Long-Evans; Sarin; Tropicamide | 2015 |
Essential Lessons in a Potential Sarin Attack Disaster Plan for a Resource-Constrained Environment.
Topics: Anticonvulsants; Atropine; Chemical Terrorism; Developing Countries; Diazepam; Health Resources; Humans; Mass Casualty Incidents; Muscarinic Antagonists; Personal Protective Equipment; Sarin | 2018 |
Optimization of the Ocular Treatment Following Organophosphate Nerve Agent Insult.
Topics: Animals; Antidotes; Atropine; Eye; Male; Miosis; Nerve Agents; Organothiophosphorus Compounds; Pupil; Rats; Rats, Long-Evans; Sarin; Tropanes; Vision, Ocular | 2017 |
Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects.
Topics: Animals; Atropine; Cerebral Cortex; Female; Male; Pirenzepine; Radioligand Assay; Rats; Receptor, Muscarinic M2; Sarin; Sex Characteristics; Time Factors; Trimedoxime; Tritium | 2018 |
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors | 2018 |
Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs.
Topics: Animals; Atropine; Cholinesterase Reactivators; Cholinesterases; Dose-Response Relationship, Drug; Drug Compounding; Electroencephalography; Guinea Pigs; Injections, Subcutaneous; Male; Obidoxime Chloride; Sarin; Structure-Activity Relationship; Survival Rate | 2018 |
Time dependent dual effect of anti-inflammatory treatments on sarin-induced brain inflammation: Suggested role of prostaglandins.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Atropine; Brain Diseases; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dinoprostone; Encephalitis; Male; Midazolam; Nerve Agents; Neuroprotective Agents; Prostaglandins; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Trimedoxime | 2019 |
Comparative physiology and efficacy of atropine and scopolamine in sarin nerve agent poisoning.
Topics: Animals; Atropine; Brain Chemistry; Chemical Warfare Agents; Cholinergic Antagonists; Electrocardiography; Electroencephalography; Male; Mice; Rats, Wistar; Sarin; Scopolamine; Telemetry | 2020 |
Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Atropine; Dose-Response Relationship, Drug; Male; Metal-Organic Frameworks; Mice; Mice, Inbred Strains; Nanoparticles; Nerve Agents; Pralidoxime Compounds; Sarin | 2022 |