Page last updated: 2024-09-05

atropine and sarin

atropine has been researched along with sarin in 91 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(sarin)
Trials
(sarin)
Recent Studies (post-2010) (sarin)
26,7111,2591,6979636270

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-199036 (39.56)18.7374
1990's19 (20.88)18.2507
2000's13 (14.29)29.6817
2010's20 (21.98)24.3611
2020's3 (3.30)2.80

Authors

AuthorsStudies
Green, DM; Inch, TD; Muir, AW; Stratton, JA1
Gordon, JJ; Leadbeater, L1
Hauser, W; Weger, N1
Bosković, B1
Fiscus, RR; Karczmar, AG; Van Meter, WG1
Bajgar, J; Hrdina, V; Jakl, A; Patocka, J1
Dettbarn, WD; Gupta, RC1
Anderson, DR; Harris, LW; Koplovitz, I; Lennox, WJ; Stewart, JR1
Fiekers, JF; Heppner, TJ1
Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG1
Liu, WF1
Alioth-Streichenberg, CM; Bodmer, DM; Waser, PG1
Anzueto, A; deLemos, RA; Hamil, H; Jenkinson, SG; Johnson, D; Moore, G; Seidenfeld, J1
Bass, KN; Das Gupta, S; Warnick, JE1
Das Gupta, S; Deshpande, SB; Warnick, JE1
Albuquerque, EX; Aracava, Y; Boyne, AF; Deshpande, SS; Idriss, M; Kawabuchi, M; Rickett, DL1
Albuquerque, EX; Deshpande, SS; Kauffman, FC; Rickett, DL; Viana, GB1
Fernando, JC; Ho, IK; Hoskins, B1
Berman, HA; Edery, H1
Inns, RH; Leadbeater, L; Rylands, JM1
Heath, C; Preston, E1
Davies, DR; Holland, P1
Aghajanian, GK; Crowell, EB; Hayes, AH; Ketchum, JS; Sidell, FR1
Baigar, J; Girdiná, V; Yákl, A1
Crone, HD1
Sidell, FR1
Bajgar, J; Hrdina, V; Jakl, A1
Clement, JG; Copeman, HT1
Lundy, PM; Shih, TM1
Clement, JG; Filbert, M1
Szinicz, L; Worek, F1
Aikawa, N; Nozaki, H1
Kirchner, T; Szinicz, L; Worek, F1
Clement, JG1
Koplovitz, I; Stewart, JR1
Das Gupta, S; Deshpande, SB; Warnick, JE; Yang, QZ1
Das Gupta, S; Pant, SC; Vijayaraghavan, R1
Aikawa, N; Fujishima, S; Hori, S; Kimura, H; Nozaki, H; Ohki, T; Sagoh, M; Shinozawa, Y; Suzuki, M; Takuma, K1
Kulling, P; Persson, SA1
Liang, J; Luo, C1
Bégos, A; Bizot, JC; Breton, P; Brochet, D; Tambuté, A; Trovero, F1
McDonough, JH; Shih, TM1
Benschop, HP; Helmich, RB; Langenberg, JP; Spruit, HE; Trap, HC; van der Wiel, HJ; van Helden, HP1
Kassa, J; Krejcová, G; Vachek, J2
Rotenberg, JS1
Breton, P; Buée, J; Calvet, JH; Christin, D; Delamanche, S; Taysse, L1
ASKEW, BM1
DECANDOLE, CA; McPHAIL, MK1
DAVIES, DR; GREEN, AL; WILLEY, GL1
STEWART, WC1
COLEMAN, IW; GRANT, GA; LITTLE, PE1
BROWN, RV1
COLBOURN, JL; CROOK, JW; GOODMAN, AI; OBERST, FW; WILLS, JH; ZVIRBLIS, P1
WILLS, JH1
LOOMIS, TA; SALAFSKY, B1
ADIE, PA; FUKUYAMA, GS; HUGHES, ER1
BANNARD, RA; COLEMAN, IW; LITTLE, PE1
HEILBRONN, E; TOLAGEN, B1
CROOK, JW; KOON, WS; OBERST, FW1
Newmark, J1
Dabisch, PA; Miller, DB; Mioduszewski, RJ; Reutter, SA; Thomson, SA1
Allon, N; Grauer, E; Manistersky, E; Rabinovitz, I; Weissman, BA1
Adler, M; Albuquerque, EX; Aracava, Y; Fawcett, WP; Hamilton, TA; Kan, RK; Oliveira, M; Pereira, EF; Randall, WR; Romano, JA1
Kellar, KJ1
Hrobak, PK1
Koplovitz, I; Maxwell, DM; Sweeney, RE; Worek, F1
McDonough, JH; O'Donnell, JC; Shih, TM; Skovira, JW1
Akkerman, M; Albuquerque, EX; Alkondon, M; Aracava, Y; Merchenthaler, I; Pereira, EF1
Cui, W; Ge, X; Luo, W; Wang, H1
Doctor, BP; Marshall, S; Morthole, V; Nambiar, MP; Oguntayo, S; Perkins, MW; Pierre, Z; Rezk, P; Sciuto, AM; Song, J1
Dillman, JF; Lumley, LA; Meyerhoff, JL; Robison, CL; Spradling, KD2
Kassa, J; Kunesova, G1
Karasova, JZ; Kassa, J; Misik, J1
Arima, Y; Itoh, T; Maeno, Y; Makita, R; Nagao, M; Namera, A; Shiraishi, H; Torikoshi, A; Watanabe, Y; Yoshizumi, M1
Gulland, A1
Kehe, K; Thiermann, H; Worek, F1
Eisenkraft, A; Kassirer, M; Kreiss, Y; Milk, N; Ophir, N; Rosman, Y; Shiyovich, A; Shrot, S1
Horova, A; Kassa, J; Matouskova, L; Musilek, K; Sepsova, V1
Bloch-Shilderman, E; Brandeis, R; Egoz, I; Gore, A; Grauer, E; Nili, U; Turetz, J1
Buchanan, S; Dippenaar, N; Laher, AE; Simo, NCT; Watermeyer, MJ1
Egoz, I; Gore, A; Grauer, E; Nili, U1
Chapman, S; Gez, R; Lazar, S; Pittel, Z1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL1
Cochrane, L; Cornelissen, AS; Joosen, MJA; Klaassen, SD; Shearer, JD; Skiadopoulos, MH; van Groningen, T; Verheij, E1
Chapman, S; Egoz, I; Gez, R; Grauer, E; Lazar, S1
Bohnert, S; Cornelissen, AS; Joosen, MJA; Klaassen, SD; van Groningen, T1
Gore, A1
Huang, C; Liu, J; Wang, Y; Yang, Y; Zhang, L; Zhao, D; Zhong, Y; Zhou, Y1

Reviews

3 review(s) available for atropine and sarin

ArticleYear
Therapy for nerve agent poisoning.
    Archives of neurology, 2004, Volume: 61, Issue:5

    Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman

2004
Limitations and challenges in treatment of acute chemical warfare agent poisoning.
    Chemico-biological interactions, 2013, Dec-05, Volume: 206, Issue:3

    Topics: Antidotes; Atropine; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Mustard Gas; Organothiophosphorus Compounds; Oximes; Sarin

2013
Broad Spectrum Treatment for Ocular Insult Induced by Organophosphate Chemical Warfare Agents.
    Toxicological sciences : an official journal of the Society of Toxicology, 2020, 09-01, Volume: 177, Issue:1

    Topics: Animals; Atropine; Chemical Warfare Agents; Eye; Nerve Agents; Organophosphate Poisoning; Organophosphates; Sarin

2020

Trials

1 trial(s) available for atropine and sarin

ArticleYear
Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates.
    Clinical toxicology, 1974, Volume: 7, Issue:1

    Topics: Adult; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Cyanosis; Depression; Electrocardiography; Epistaxis; Humans; Insecticides; Male; Mental Disorders; Middle Aged; Placebos; Pralidoxime Compounds; Pyridinium Compounds; Respiration; Sarin; Scopolamine; Soman; Sulfisoxazole; Tachycardia; Time Factors

1974

Other Studies

87 other study(ies) available for atropine and sarin

ArticleYear
Dual mechanism of the antidotal action of atropine-like drugs in poisoning by organophosphorus anticholinesterases.
    The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:1

    Topics: Animals; Anticonvulsants; Antidotes; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Mice; Mydriatics; Nicotine; Organophosphate Poisoning; Parasympatholytics; Pentylenetetrazole; Rats; Sarin; Stereoisomerism; Time Factors

1977
The prophylactic use of l-methyl, 2-hydroxyiminomethylpyridinium methanesulfonate (P2S) in the treatment of organophosphate poisoning.
    Toxicology and applied pharmacology, 1977, Volume: 40, Issue:1

    Topics: Animals; Atropine; Drug Therapy, Combination; Female; Guinea Pigs; Lethal Dose 50; Mesylates; Organophosphate Poisoning; Pralidoxime Compounds; Rabbits; Sarin; Soman; Time Factors

1977
Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1979, Issue:2

    Topics: Animals; Antidotes; Aspartate Aminotransferases; Atropine; Benactyzine; Cholinesterase Inhibitors; Cholinesterases; Creatine Kinase; Dogs; Lethal Dose 50; Male; Organothiophosphorus Compounds; Pyridinium Compounds; Sarin; Soman

1979
The influence of 2-/o-cresyl/-4 H-1 : 3 : 2-benzodioxa-phosphorin-2-oxide (CBDP) on organophosphate poisoning and its therapy.
    Archives of toxicology, 1979, Jul-11, Volume: 42, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Cyclic P-Oxides; Drug Interactions; Liver; Male; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Sarin; Soman; Structure-Activity Relationship

1979
CNS effects of anticholinesterases in the presence of inhibited cholinesterases.
    Archives internationales de pharmacodynamie et de therapie, 1978, Volume: 231, Issue:2

    Topics: Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterases; Electroencephalography; Electrophysiology; Isoflurophate; Male; Physostigmine; Rabbits; Sarin

1978
Antidotal therapy and changes of acetylcholinesterase activity following isopropyl methylphosphonofluoridate intoxication in mice.
    Acta biologica et medica Germanica, 1975, Volume: 34, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Sarin; Trimedoxime

1975
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
    Neurotoxicology, 1992,Fall, Volume: 13, Issue:3

    Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine

1992
Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1992, Volume: 18, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin

1992
The effects of irreversible acetylcholinesterase inhibitors on transmission through sympathetic ganglia of the bullfrog.
    Neuropharmacology, 1991, Volume: 30, Issue:8

    Topics: Acetylcholine; Action Potentials; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Ganglia, Sympathetic; Organothiophosphorus Compounds; Rana catesbeiana; Sarin; Soman; Synaptic Transmission

1991
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
    Drug and chemical toxicology, 1991, Volume: 14, Issue:3

    Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl

1991
A symptomatological assessment of organophosphate-induced lethality in mice: comparison of atropine and clonidine protection.
    Toxicology letters, 1991, Volume: 56, Issue:1-2

    Topics: Animals; Atropine; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphorus Compounds; Poisoning; Sarin

1991
Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats.
    Toxicology and applied pharmacology, 1991, Volume: 108, Issue:3

    Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Female; Obidoxime Chloride; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Sarin

1991
Acute inhalation toxicity of soman and sarin in baboons.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1990, Volume: 14, Issue:4

    Topics: Administration, Inhalation; Airway Resistance; Animals; Apnea; Arrhythmias, Cardiac; Atropine; Blood Pressure; Bronchoalveolar Lavage Fluid; Diaphragm; Heart Block; Hemodynamics; Hypoxia; Injections, Intravenous; Lung; Neutrophils; Organophosphorus Compounds; Papio; Respiration; Sarin; Soman

1990
Interaction of reversible and irreversible cholinesterase inhibitors on the monosynaptic reflex in neonatal rats.
    Toxicology and applied pharmacology, 1989, Jun-01, Volume: 99, Issue:1

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Physostigmine; Pregnancy; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Reflex, Monosynaptic; Sarin; Spinal Cord

1989
Segmental synaptic depression caused by diisopropylphosphorofluoridate and sarin is reversed by thyrotropin-releasing hormone in the neonatal rat spinal cord.
    Toxicology and applied pharmacology, 1988, Sep-30, Volume: 95, Issue:3

    Topics: Animals; Animals, Newborn; Atropine; Cholinesterases; Isoflurophate; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Reflex, Monosynaptic; Sarin; Spinal Cord; Thyrotropin-Releasing Hormone

1988
Multiple actions of anticholinesterase agents on chemosensitive synapses: molecular basis for prophylaxis and treatment of organophosphate poisoning.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:6 Pt 2

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Female; Ganglionic Blockers; Grasshoppers; In Vitro Techniques; Muscle Contraction; Organophosphate Poisoning; Organothiophosphorus Compounds; Physostigmine; Rana pipiens; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Sarin; Synapses

1985
Effectiveness of physostigmine as a pretreatment drug for protection of rats from organophosphate poisoning.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 6, Issue:3

    Topics: Acetylcholinesterase; Action Potentials; Animals; Atropine; Body Weight; Brain; Brain Chemistry; Cholinesterases; Female; gamma-Aminobutyric Acid; Muscle Contraction; Muscles; Neostigmine; Organophosphate Poisoning; Physostigmine; Pyridostigmine Bromide; Rats; Rats, Inbred Strains; Sarin

1986
Hypersensitivity to antimuscarinic agents following brief exposure to Soman and Sarin.
    Journal of toxicology and environmental health, 1986, Volume: 18, Issue:1

    Topics: Animals; Atropine; Atropine Derivatives; Drug Hypersensitivity; Male; Organophosphorus Compounds; Parasympatholytics; Rats; Rats, Inbred Strains; Sarin; Soman; Stereotyped Behavior; Tremor

1986
Yohimbine antagonism of the vasodepression elicited by organophosphates applied on ventral medulla oblongata.
    Journal of the autonomic nervous system, 1985, Volume: 14, Issue:3

    Topics: Animals; Atropine; Blood Pressure; Cats; Cholinesterase Inhibitors; Electrocardiography; Female; Injections, Intraventricular; Male; Medulla Oblongata; Norepinephrine; Organophosphorus Compounds; Respiration; Sarin; Soman; Yohimbine

1985
Treatment of poisoning by soman.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:6 Pt 2

    Topics: Animals; Antidotes; Atropine; Carbamates; Diazepam; Guinea Pigs; Male; Motor Activity; Organophosphate Poisoning; Parasympatholytics; Phenylpropionates; Physostigmine; Pyridostigmine Bromide; Sarin; Soman; Time Factors

1985
Atropine-insensitive vasodilatation and hypotension in the organophosphate-poisoned rabbit.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 200, Issue:2

    Topics: Animals; Atropine; Blood Pressure; Blood Vessels; Cholinesterase Inhibitors; Forelimb; Heart Rate; Hypotension; Isoflurophate; Organophosphate Poisoning; Rabbits; Respiration, Artificial; Sarin; Soman; Vascular Resistance; Vasodilator Agents

1972
Effect of oximes and atropine upon the development of delayed neurotoxic signs in chickens following poisoning by DFP and sarin.
    Biochemical pharmacology, 1972, Dec-01, Volume: 21, Issue:23

    Topics: Animals; Atropine; Chickens; Cholinesterase Inhibitors; Isoflurophate; Lethal Dose 50; Neurons; Organophosphorus Compounds; Oximes; Sarin; Time Factors

1972
Atropine, scopolamine, and ditran: comparative pharmacology and antagonists in man.
    Psychopharmacologia, 1973, Jan-01, Volume: 28, Issue:2

    Topics: Acridines; Adult; Atropine; Behavior; Blood Pressure; Central Nervous System; Delirium; Glycolates; Heart Rate; Human Experimentation; Humans; Isoflurophate; Male; Memory; Methylphenidate; Neostigmine; Parasympatholytics; Physostigmine; Piperidines; Respiration; Sarin; Scopolamine

1973
[Therapeutic action of some pyridine series dioximes in experimental O-isopropyl-methyl-fluorophosphonate poisoning].
    Farmakologiia i toksikologiia, 1973, Volume: 36, Issue:5

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Drug Combinations; Male; Mice; Organophosphate Poisoning; Oximes; Pyridines; Sarin

1973
Can allosteric effectors of acetylcholinesterase control the rate of ageing of the phosphonylated enzyme?
    Biochemical pharmacology, 1974, Jan-15, Volume: 23, Issue:2

    Topics: Acetylcholinesterase; Allyl Compounds; Animals; Atropine; Cattle; Coumarins; Erythrocytes; Gallamine Triethiodide; Rabbits; Sarin; Toxiferine; Tropanes; Tubocurarine

1974
The influence of obidoxime on acetylcholinesterase activity in different parts of the mouse brain following isopropylmethyl phosphonofluoridate intoxication.
    European journal of pharmacology, 1972, Volume: 19, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Diencephalon; Dose-Response Relationship, Drug; Male; Medulla Oblongata; Mesencephalon; Mice; Organophosphate Poisoning; Pons; Pyridinium Compounds; Sarin

1972
Soman and sarin induce a long-lasting naloxone-reversible analgesia in mice.
    Life sciences, 1984, Apr-09, Volume: 34, Issue:15

    Topics: Analgesics; Animals; Atropine; Dose-Response Relationship, Drug; Hot Temperature; Male; Mice; Naloxone; Organophosphorus Compounds; Reaction Time; Sarin; Soman

1984
Examination of the role of central cholinergic mechanisms in the therapeutic effects of HI-6 in organophosphate poisoning.
    Journal of neurochemistry, 1983, Volume: 40, Issue:5

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Injections, Intraventricular; Lethal Dose 50; Male; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman

1983
Antidote effect of sodium fluoride against organophosphate poisoning in mice.
    Life sciences, 1983, Apr-18, Volume: 32, Issue:16

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carboxylesterase; Carboxylic Ester Hydrolases; Drug Interactions; Fluorides; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Sarin; Sodium Fluoride; Soman

1983
Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment.
    Archives of toxicology, 1995, Volume: 69, Issue:5

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Drug Synergism; Female; Guinea Pigs; Heart Function Tests; Organothiophosphorus Compounds; Oximes; Pyridostigmine Bromide; Respiration; Respiratory Function Tests; Sarin

1995
Treatment of nerve gas poisoning.
    The Medical letter on drugs and therapeutics, 1995, May-12, Volume: 37, Issue:948

    Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman

1995
Sarin poisoning in Tokyo subway.
    Lancet (London, England), 1995, Jun-03, Volume: 345, Issue:8962

    Topics: Atropine; Female; Humans; Male; Middle Aged; Miosis; Sarin; Vision Disorders

1995
Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin.
    Toxicology, 1995, Jan-06, Volume: 95, Issue:1-3

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Blood Pressure; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Guinea Pigs; Heart Rate; Oximes; Poisoning; Pyridines; Pyridinium Compounds; Respiration; Sarin

1995
Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes.
    Archives of toxicology, 1994, Volume: 68, Issue:1

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Drug Synergism; Injections, Subcutaneous; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Poisoning; Sarin

1994
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
    Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms

1994
Biphasic action of sarin on monosynaptic reflex in the neonatal rat spinal cord in vitro.
    Archives of toxicology, 1993, Volume: 67, Issue:5

    Topics: Animals; Animals, Newborn; Atropine; Electric Stimulation; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Nicotinic Antagonists; Parasympatholytics; Pregnancy; Rats; Rats, Wistar; Reflex, Monosynaptic; Sarin; Spinal Cord

1993
Sarin induced lung pathology and protection by standard therapy regime.
    Biomedical and environmental sciences : BES, 1993, Volume: 6, Issue:2

    Topics: Animals; Atropine; Cholinesterase Reactivators; Diazepam; Environmental Exposure; Lung; Male; Pralidoxime Compounds; Rats; Sarin

1993
Secondary exposure of medical staff to sarin vapor in the emergency room.
    Intensive care medicine, 1995, Volume: 21, Issue:12

    Topics: Adult; Atropine; Disasters; Emergency Medical Services; Female; Humans; Japan; Male; Medical Staff, Hospital; Middle Aged; Muscarinic Antagonists; Occupational Exposure; Retrospective Studies; Sarin; Violence; Vision Disorders

1995
[The nerve gas terrorist attack in Tokyo subway 1995. Cooperation during the relief work is necessary].
    Lakartidningen, 1997, Jun-18, Volume: 94, Issue:25

    Topics: Atropine; Disaster Planning; Gas Poisoning; Humans; Parasympatholytics; Pralidoxime Compounds; Railroads; Sarin; Tokyo; Violence

1997
Evaluation of combined toxic effects of GB/GF and efficacy of jielin injection against combined poisoning in mice.
    Toxicology letters, 1997, Aug-22, Volume: 92, Issue:3

    Topics: Animals; Antidotes; Atropine; Benactyzine; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Humans; Injections; Male; Mice; Organophosphorus Compounds; Pralidoxime Compounds; Sarin; Software

1997
Pharmacological profile of CEB-1957 and atropine toward brain muscarinic receptors and comparative study of their efficacy against sarin poisoning.
    Toxicology and applied pharmacology, 1998, Volume: 150, Issue:2

    Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Brain; Cholinesterase Inhibitors; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Poisoning; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Sarin; Thiophenes

1998
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication.
    Archives of toxicology, 2000, Volume: 74, Issue:3

    Topics: Animals; Anticonvulsants; Atropine; Biperiden; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Seizures; Soman

2000
Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs.
    Toxicology and applied pharmacology, 2000, Dec-15, Volume: 169, Issue:3

    Topics: Acetylcholinesterase; Administration, Inhalation; Animals; Area Under Curve; Atropine; Chemical Warfare Agents; Guinea Pigs; Injections, Intravenous; Male; Sarin; Stereoisomerism

2000
Effect of atropine and the oxime HI-6 on low-level sarin-induced alteration of performance of rats in a T-maze.
    Acta medica (Hradec Kralove), 2002, Volume: 45, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Maze Learning; Muscarinic Antagonists; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2002
The impairment of spatial memory following low-level sarin inhalation exposure and antidotal treatment in rats.
    Acta medica (Hradec Kralove), 2002, Volume: 45, Issue:4

    Topics: Administration, Inhalation; Animals; Antidotes; Atropine; Male; Maze Learning; Memory; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2002
Diagnosis and management of nerve agent exposure.
    Pediatric annals, 2003, Volume: 32, Issue:4

    Topics: Antidotes; Atropine; Benzodiazepines; Bioterrorism; Chemical Warfare Agents; Child; Environmental Exposure; Humans; Organophosphate Poisoning; Resuscitation; Sarin; Triage

2003
Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose.
    Toxicology, 2003, Jun-30, Volume: 188, Issue:2-3

    Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Interactions; Electroencephalography; Guinea Pigs; Histocytochemistry; Muscarinic Antagonists; Nervous System Diseases; Pralidoxime Compounds; Prodrugs; Pyridostigmine Bromide; Respiratory Insufficiency; Sarin; Seizures

2003
Oximes and atropine in sarin poisoning.
    British journal of pharmacology and chemotherapy, 1957, Volume: 12, Issue:3

    Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diacetyl; Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Hydroxylamines; Mice; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Rats; Sarin

1957
Sarin and paraoxon antagonism in different.
    Canadian journal of biochemistry and physiology, 1957, Volume: 35, Issue:11

    Topics: Atropine; Autonomic Agents; Bis-Trimethylammonium Compounds; Cholinesterase Inhibitors; Humans; Paraoxon; Parathion; Phosphates; Sarin

1957
2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate and atropine in the treatment of severe organophosphate poisoning.
    British journal of pharmacology and chemotherapy, 1959, Volume: 14, Issue:1

    Topics: Animals; Atropine; Diphosphates; Humans; Insecticides; Male; Mesylates; Organophosphate Poisoning; Oximes; Phosphates; Pralidoxime Compounds; Pyrans; Pyridinium Compounds; Sarin

1959
The effects of sarin and atropine on the respiratory center and neuromuscular junctions of the rat.
    Canadian journal of biochemistry and physiology, 1959, Volume: 37, Issue:5

    Topics: Animals; Atropine; Cell Respiration; Cholinesterase Inhibitors; Neuromuscular Junction; Phosphates; Rats; Respiration; Respiratory Center; Sarin

1959
Oxime mixtures and atropine in the protection of mice and rats from sarin poisoning.
    Canadian journal of biochemistry and physiology, 1960, Volume: 38

    Topics: Animals; Atropine; Hydroxylamines; Mice; Oximes; Phosphates; Rats; Sarin

1960
The effects of intracisternal sarin and pyridine-2-aldoxime methyl methanesulphonate in anesthetized dogs.
    British journal of pharmacology and chemotherapy, 1960, Volume: 15

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Methyl Methanesulfonate; Oximes; Phosphates; Pyridines; Sarin

1960
Adjunctive value of oral prophylaxis with the oximes 2-PAM lactate and 2-PAM methanesulfonate to therapeutic administration of atropine in dogs poisoned by inhaled Sarin vapor.
    The Journal of pharmacology and experimental therapeutics, 1962, Volume: 136

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Lactic Acid; Mesylates; Oximes; Phosphates; Pralidoxime Compounds; Pyridines; Sarin

1962
Anticholinergic compounds as a adjuncts to atropine in preventing lethality by Sarin in the rabbit.
    Journal of medicinal and pharmaceutical chemistry, 1961, Mar-01, Volume: 3

    Topics: Animals; Atropine; Cholinergic Antagonists; Parasympatholytics; Phosphates; Rabbits; Sarin

1961
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION.
    Toxicology and applied pharmacology, 1963, Volume: 5

    Topics: Atropine; Cholinesterase Inhibitors; Enzyme Inhibitors; Mice; Neostigmine; Neuromuscular Junction; Organophosphate Poisoning; Oximes; Pharmacology; Phosphorus; Poisons; Pralidoxime Compounds; Pyridines; Rats; Research; Sarin; Soman; Toxicology

1963
INCREASED CONCENTRATIONS OF BLOOD LIPIDS IN GUINEA PIGS POISONED BY SARIN.
    Nature, 1963, Nov-30, Volume: 200

    Topics: Atropine; Blood Chemical Analysis; Guinea Pigs; Hyperlipidemias; Lipids; Muscle Spasticity; Organophosphate Poisoning; Oximes; Paralysis; Phosphorus; Poisons; Research; Sarin; Toxicology

1963
CHOLINOLYTICS IN THE TREATMENT OF ANTICHOLINESTERASE POISONING. III. THE EFFECTS OF QUATERNIZATION AND ALTERATION OF ANIONIC FUNCTION OF THE POTENCY OF CHOLINOLYTICS IN THE TREATMENT OF SARIN POISONING.
    Canadian journal of biochemistry and physiology, 1963, Volume: 41

    Topics: Absorption; Ammonium Compounds; Atropine; Autonomic Agents; Blood Chemical Analysis; Cholinergic Antagonists; Cholinesterase Inhibitors; Mice; Organophosphate Poisoning; Oximes; Parasympatholytics; Phosphorus; Poisons; Quaternary Ammonium Compounds; Research; Sarin; Therapeutics; Toxicology

1963
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONING.
    Biochemical pharmacology, 1965, Jan-01, Volume: 14

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pharmacology; Phosphates; Research; Sarin; Soman; Toxicology

1965
The effectiveness of 2-PAM and TMB-4 as adjuncts to atropine therapy in dogs exposed to Sarin vapor by inhalation.
    The Journal of pharmacology and experimental therapeutics, 1962, Volume: 136

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Dogs; Hydroxylamines; Phosphates; Pralidoxime Compounds; Pyridines; Sarin; Trimedoxime

1962
Miotic tolerance to sarin vapor exposure: role of the sympathetic and parasympathetic nervous systems.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 85, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Cholinesterase Inhibitors; Gases; Infrared Rays; Male; Miosis; Parasympathetic Nervous System; Parasympatholytics; Phentolamine; Pupil; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sarin; Sympathetic Nervous System

2005
Acute and long-lasting cardiac changes following a single whole-body exposure to sarin vapor in rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 87, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Atropine; Behavior, Animal; Blood Pressure; Chemical Warfare Agents; Cholinesterase Inhibitors; Electrocardiography; Epinephrine; Heart; Inhalation Exposure; Lethal Dose 50; Long QT Syndrome; Male; Muscarinic Antagonists; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Sarin; Scopolamine; Spectroscopy, Fourier Transform Infrared; Vasoconstrictor Agents

2005
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Aug-29, Volume: 103, Issue:35

    Topics: Acetylcholinesterase; Alkaloids; Animals; Atropine; Behavior, Animal; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Lethal Dose 50; Neurons; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Poisoning; Pyridostigmine Bromide; Sarin; Sesquiterpenes; Soman; Time Factors

2006
Overcoming inhibitions.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Sep-05, Volume: 103, Issue:36

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Neurons; Neurotransmitter Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Paraoxon; Pralidoxime Compounds; Pyridostigmine Bromide; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Seizures; Soman; Time Factors

2006
Nerve agents: implications for anesthesia providers.
    AANA journal, 2008, Volume: 76, Issue:2

    Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors

2008
A structure-activity analysis of the variation in oxime efficacy against nerve agents.
    Toxicology and applied pharmacology, 2008, Sep-01, Volume: 231, Issue:2

    Topics: Acetylcholinesterase; Animals; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Linear Models; Male; Obidoxime Chloride; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship

2008
Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication.
    Journal of molecular neuroscience : MN, 2010, Volume: 40, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diacetyl; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Guinea Pigs; Injections, Intramuscular; Male; Muscarinic Antagonists; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Sarin; Seizures; Treatment Outcome; Up-Regulation

2010
Molecular and cellular actions of galantamine: clinical implications for treatment of organophosphorus poisoning.
    Journal of molecular neuroscience : MN, 2010, Volume: 40, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Atropine; Brain; Chemical Warfare Agents; Cholinergic Fibers; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Interactions; Female; Galantamine; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Nerve Degeneration; Organ Culture Techniques; Organophosphate Poisoning; Organophosphorus Compounds; Sarin; Soman; Treatment Outcome

2010
Targeting cholinesterase inhibitor poisoning with a novel blocker against both nicotinic and muscarinic receptors.
    Neurotoxicity research, 2010, Volume: 18, Issue:2

    Topics: Animals; Atropine; Benzilates; Cell Line; Cholinergic Antagonists; Cholinesterase Inhibitors; Guinea Pigs; Membrane Potentials; Mice; Organothiophosphorus Compounds; Patch-Clamp Techniques; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Receptors, Nicotinic; Sarin

2010
Endotracheal aerosolization of atropine sulfate protects against soman-induced acute respiratory toxicity in guinea pigs.
    Inhalation toxicology, 2011, Volume: 23, Issue:4

    Topics: Acetylcholinesterase; Administration, Inhalation; Animals; Atropine; Body Weight; Bronchoalveolar Lavage Fluid; Butyrylcholinesterase; Chemical Warfare Agents; Guinea Pigs; Heart Rate; Inhalation Exposure; Lethal Dose 50; Lung; Male; Plethysmography, Whole Body; Respiratory Tract Diseases; Sarin; Soman; Tidal Volume; Trachea

2011
Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures.
    Journal of neuroinflammation, 2011, Jul-21, Volume: 8

    Topics: Animals; Anticonvulsants; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Male; Microarray Analysis; Muscarinic Antagonists; Pralidoxime Compounds; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Signal Transduction; Transcription, Genetic

2011
Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin.
    Journal of neuroinflammation, 2011, Jul-21, Volume: 8

    Topics: Amygdala; Animals; Anticonvulsants; Atropine; Cerebral Cortex; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Gene Expression Profiling; Gene Regulatory Networks; Hippocampus; Interleukin-1beta; Interleukin-6; Male; Microarray Analysis; Muscarinic Antagonists; Oximes; Principal Component Analysis; Pyridines; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Septum of Brain; Thalamus; Transcription, Genetic; Tumor Necrosis Factor-alpha

2011
The benefit of combination of oximes for the neuroprotective efficacy of antidotal treatment of sarin-poisoned rats.
    Toxicology mechanisms and methods, 2012, Volume: 22, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Molecular Structure; Neuroprotective Agents; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Trimedoxime

2012
A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:5

    Topics: Animals; Antidotes; Atropine; Autonomic Nervous System; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Czech Republic; Drug Therapy, Combination; Lethal Dose 50; Male; Muscarinic Antagonists; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Psychomotor Performance; Pyridinium Compounds; Rats; Rats, Wistar; Sarin

2012
Acute effects of a sarin-like organophosphorus agent, bis(isopropyl methyl)phosphonate, on cardiovascular parameters in anaesthetized, artificially ventilated rats.
    Toxicology and applied pharmacology, 2013, Oct-01, Volume: 272, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesia; Animals; Atropine; Blood Pressure; Chemical Warfare Agents; Diphosphonates; Heart Rate; Hemodynamics; Male; Muscarinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Respiration, Artificial; Sarin

2013
Lack of atropine in Syria hampers treatment after gas attacks.
    BMJ (Clinical research ed.), 2013, Sep-03, Volume: 347

    Topics: Atropine; Chemical Warfare Agents; Humans; Muscarinic Antagonists; Poisoning; Sarin; Syria

2013
Lessons learned from the Syrian sarin attack: evaluation of a clinical syndrome through social media.
    Annals of internal medicine, 2014, May-06, Volume: 160, Issue:9

    Topics: Atropine; Chemical Terrorism; Child; Cholinergic Antagonists; Decontamination; Disaster Planning; Female; Humans; Infant; Injections, Intravenous; Male; Mass Casualty Incidents; Poisoning; Sarin; Social Media; Syria

2014
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.
    Toxicology mechanisms and methods, 2015, Volume: 25, Issue:3

    Topics: Acetylcholinesterase; Animals; Animals, Outbred Strains; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diaphragm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Obidoxime Chloride; Oximes; Pyridinium Compounds; Rats, Wistar; Sarin

2015
Synergism Between Anticholinergic and Oxime Treatments Against Sarin-Induced Ocular Insult in Rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 146, Issue:2

    Topics: Administration, Ophthalmic; Animals; Atropine; Cholinesterase Reactivators; Drug Synergism; Eye; Male; Miosis; Oximes; Rats; Rats, Long-Evans; Sarin; Tropicamide

2015
Essential Lessons in a Potential Sarin Attack Disaster Plan for a Resource-Constrained Environment.
    Disaster medicine and public health preparedness, 2018, Volume: 12, Issue:2

    Topics: Anticonvulsants; Atropine; Chemical Terrorism; Developing Countries; Diazepam; Health Resources; Humans; Mass Casualty Incidents; Muscarinic Antagonists; Personal Protective Equipment; Sarin

2018
Optimization of the Ocular Treatment Following Organophosphate Nerve Agent Insult.
    Toxicological sciences : an official journal of the Society of Toxicology, 2017, 09-01, Volume: 159, Issue:1

    Topics: Animals; Antidotes; Atropine; Eye; Male; Miosis; Nerve Agents; Organothiophosphorus Compounds; Pupil; Rats; Rats, Long-Evans; Sarin; Tropanes; Vision, Ocular

2017
Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects.
    Neurotoxicology, 2018, Volume: 65

    Topics: Animals; Atropine; Cerebral Cortex; Female; Male; Pirenzepine; Radioligand Assay; Rats; Receptor, Muscarinic M2; Sarin; Sex Characteristics; Time Factors; Trimedoxime; Tritium

2018
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
    Toxicology, 2018, 09-01, Volume: 408

    Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors

2018
Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs.
    Chemico-biological interactions, 2018, Dec-25, Volume: 296

    Topics: Animals; Atropine; Cholinesterase Reactivators; Cholinesterases; Dose-Response Relationship, Drug; Drug Compounding; Electroencephalography; Guinea Pigs; Injections, Subcutaneous; Male; Obidoxime Chloride; Sarin; Structure-Activity Relationship; Survival Rate

2018
Time dependent dual effect of anti-inflammatory treatments on sarin-induced brain inflammation: Suggested role of prostaglandins.
    Neurotoxicology, 2019, Volume: 74

    Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Atropine; Brain Diseases; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dinoprostone; Encephalitis; Male; Midazolam; Nerve Agents; Neuroprotective Agents; Prostaglandins; Rats; Rats, Sprague-Dawley; Sarin; Seizures; Trimedoxime

2019
Comparative physiology and efficacy of atropine and scopolamine in sarin nerve agent poisoning.
    Toxicology and applied pharmacology, 2020, 06-01, Volume: 396

    Topics: Animals; Atropine; Brain Chemistry; Chemical Warfare Agents; Cholinergic Antagonists; Electrocardiography; Electroencephalography; Male; Mice; Rats, Wistar; Sarin; Scopolamine; Telemetry

2020
Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents.
    Inorganic chemistry, 2022, Jan-24, Volume: 61, Issue:3

    Topics: Acetylcholinesterase; Administration, Oral; Animals; Atropine; Dose-Response Relationship, Drug; Male; Metal-Organic Frameworks; Mice; Mice, Inbred Strains; Nanoparticles; Nerve Agents; Pralidoxime Compounds; Sarin

2022