arginine and piperidines
arginine has been researched along with piperidines in 94 studies
Research
Studies (94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (15.96) | 18.7374 |
| 1990's | 44 (46.81) | 18.2507 |
| 2000's | 25 (26.60) | 29.6817 |
| 2010's | 6 (6.38) | 24.3611 |
| 2020's | 4 (4.26) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hijikate, A; Ikezawa, K; Kikimoto, R; Okamoto, S; Tamao, Y; Tonomura, S | 1 |
| Hijikata, A; Kikumoto, R; Okamoto, S; Tamao, Y; Tonomura, S | 1 |
| Lewis, DA; Miller, VM | 1 |
| Hiramatsu, Y; Itokazu, Y; Kinoshita, T; Koida, M; Kurio, W; Maeda, H; Manno, K; Nakamuta, H; Ogawa, Y; Ozaki, K | 1 |
| Bode, W; Brandstetter, H; Edwards, BF; Grosse, D; Hoeffken, HW; Martin, PD; Stürzebecher, J; Turk, D | 1 |
| Bolofo, ML; Giles, H; Martin, GR | 1 |
| Banner, DW; Hadváry, P | 2 |
| Bode, W; Stürzebecher, J; Turk, D | 1 |
| Blachier, F; Malaisse, WJ; Mourtada, A; Sener, A | 1 |
| Christensen, HN; Hellman, B; Lernmark, A; Sehlin, J; Tager, HS; Täljedal, IB | 1 |
| Christensen, HN; Ronquist, G | 1 |
| McConnell, HM; Ogata, RT | 1 |
| Christensen, HN; Fajans, SS; Floyd, JC; Pek, S | 1 |
| Crawhall, JC; Watts, RW | 1 |
| Greenblatt, M; Lijinsky, W | 1 |
| Conn, JW; Fajans, SS; Floyd, JC; Knopf, RF; Pek, S; Weissman, P | 1 |
| Asatoor, AM; Crouchman, MR; Harrison, AR; Light, FW; Loughridge, LW; Milne, MD; Richards, AJ | 1 |
| Treacher, RJ | 1 |
| Hoffmann, J; Markwardt, F; Nowak, G | 1 |
| Hijikata, A; Kikumoto, R; Kinjo, K; Oda, K; Ohtsu, K; Okamoto, S; Tamao, Y | 1 |
| Shikada, K; Tanaka, S | 1 |
| Brain, SD; Hall, JM | 1 |
| Giuliani, S; Maggi, CA; Zagorodnyuk, V | 1 |
| Abe, K; Hashimoto, J; Imai, Y; Minami, N | 1 |
| Bova, MP; Feldman, PL; Fukuto, JM; Stuehr, DJ; Wong, P | 1 |
| Claing, A; D'Orléans-Juste, P; Gratton, JP; Maurice, MC; Télémaque, S; Yano, M | 1 |
| Charette, L; Foulon, D; Jones, TR; Rodger, IW | 1 |
| Delbro, DS; Gustafsson, BI | 1 |
| Burgaud, JL; Oudart, N | 1 |
| Claeson, G; Ehrhardt, C; Metternich, R; Scully, MF; Stone, SR; Tapparelli, C; Zurini, M | 1 |
| Gallagher, MJ; Huang, H; Lynch, DR; Pritchett, DB | 1 |
| Ferguson, MK; Reeder, LB | 1 |
| Giuliani, S; Maggi, CA | 1 |
| Okabe, S; Takahashi, S | 1 |
| Grootenhuis, PD; Karplus, M | 1 |
| Börjesson, I; Elg, M; Gustafsson, D; Lenfors, S; Teger-Nilsson, AC | 1 |
| Ea-Kim, L; Javellaud, J; Oudart, N | 1 |
| Lesage, AS; Leysen, JE; Peeters, L | 1 |
| Verstraete, M | 1 |
| Clark, DE; Murray, CW; Westhead, DR | 1 |
| Prasa, D; Stürzebecher, J; Svendsen, L | 1 |
| Deinum, J; Elg, M; Gustafsson, D | 1 |
| Hirayama, F; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y | 2 |
| Hirayama, F; Hisamichi, N; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y | 1 |
| Hirayama, F; Kawasaki, T; Koshio, H; Matsumoto, Y; Sakai, Y; Sato, K; Taniuchi, Y | 1 |
| Deschenes, I; DiMaio, J; Finkle, CD; Leblond, L; St Pierre, A; Winocour, PD | 1 |
| Naylor-Olsen, AM; Sanderson, PE | 1 |
| Aizenman, E; Brimecombe, JC; Gallagher, MJ; Lynch, DR | 1 |
| Alonso, MJ; González, R; Marín, J; Martínez-Orgado, J; Rodríguez-Martínez, MA; Sánchez-Ferrer, CF | 1 |
| Alexopoulos, K; Holada, K; Matsoukas, J; Mavromoustakos, T; Roumelioti, P; Tselios, T | 1 |
| Albrecht, DM; Flüth, H; Heller, A; Koch, T; Müller, M; Ragaller, M; Schmeck, J | 1 |
| Deinum, J; Nilsson, T; Sjöling-Ericksson, A | 1 |
| Cadieux, A; D'Orléans-Juste, P; Gratton, JP; Lewis, K; Rae, GA | 1 |
| Abe, Y; Fujisawa, Y; Miyanaka, H; Miyatake, A; Mori, N; Yube, K | 1 |
| Allen, MC; Ambler, J; Brundish, D; Bull, A; Butler, K; Donovan, V; Fullerton, JD; Garman, SM; Hayler, JF; Howarth, G; Hoyle, W; Janus, D; Kane, PD; McDonnell, M; Smith, GP; Talbot, MD; Wakeford, R; Walker, CV | 1 |
| Costa, S; Monti, LD; Phan, CV; Piatti, PM; Pontiroli, AE; Pozza, G; Sandoli, EP; Valsecchi, G | 1 |
| Itoh, Z; Suzuki, H; Tohara, K; Uchida, Y | 1 |
| Collen, D; Kozawa, O; Matsuno, H; Matsuo, O; Uematsu, T; Ueshima, S | 1 |
| Andersson, K; Fujiwara, M; Persson, K | 1 |
| Aisaka, K; Hayashi, M; Matsuo, A; Nakamoto, H | 1 |
| Belotti, D; Cossy, J | 1 |
| Ishida, Y; Kohno, T; Nakamura, H; Nakamura, M; Niwa, Y; Oba, Y; Sato, K | 1 |
| Hayakawa, H; Hirata, Y; Homma, Y; Horie, S; Kawabe, K; Kitamura, T; Minowada, S; Nagai, R; Nagata, D; Nishimatsu, H; Ohta, N; Satonaka, H; Suzuki, E; Takeuchi, T | 1 |
| Kozawa, O; Matsuno, H; Matsuo, O; Okada, K; Uematsu, T; Ueshima, S | 1 |
| Joshi, P; Kirschbaum, KS; Muthalagi, M; Parihar, HS; Schulte, MK; Venkatachalan, SP; Venkataraman, P | 1 |
| Andersson, KE; Pandita, RK | 1 |
| Akahane, S; Hara, K; Honma, T; Koizumi, T; Kojima, M; Matsuzawa, A; Uchida, M | 1 |
| Bhardwaj, A; Goyagi, T; Hurn, PD; Kirsch, JR; Koehler, RC; Toung, TJ; Traystman, RJ | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| LUCK, JM; MURRAY, K; NEUSTAEDTER, J; RASMUSSEN, PS | 1 |
| Ieko, M; Koike, T; Naito, S; Nakabayashi, T; Takeda, M; Tarumi, T | 1 |
| Cossy, J | 1 |
| Chu, CP; Jin, QH; Kannan, H; Kato, K; Oiso, Y; Qiu, DL; Yu, NS | 1 |
| Baxi, SM; Chi, L; Gould, WR; Johnson, TR; Leadley, RJ; McClanahan, TB; Saiya-Cork, K; Welch, KM | 1 |
| Martásek, P; Roman, LJ; Seo, J; Silverman, RB | 1 |
| Massoudi, R; Moghaddam, AH; Roohbakhsh, A; Zarrindast, MR | 1 |
| Fedorov, A; Hemminga, MA; Hesselink, RW; Prieto, M | 1 |
| Di, S; Franco, A; Maxson, MM; Tasker, JG | 1 |
| Bahremand, A; Dehpour, AR; Ghasemi, M; Nasrabady, SE; Shafaroodi, H | 1 |
| Aydin, B; Cabadak, H; Kan, B; Küçükibrahimoğlu, E; Zafer Gören, M | 1 |
| Dehpour, AR; Ghaffarpour, M; Ghasemi, M; Gholipour, T; Riazi, K | 1 |
| Andrade-Gordon, P; Costanzo, MJ; Damiano, BP; de Garavilla, L; Giardino, EC; Haertlein, BJ; Maryanoff, BE | 1 |
| Cheung, CW; Irwin, MG; Liu, YT; Lv, H; Song, JG; Tao, KM; Wong, GT; Wu, FX; Yang, LQ; Yu, WF | 1 |
| Bachaalany, S; Bettaieb, A; Chahed, S; Griffey, S; Haj, FG; Hammock, BD | 1 |
| Goto, K; Nakano, T; Shimomura, T; Wakabayashi, I | 1 |
| André, F; Dansette, PM; Graves, JP; Lafite, P; Mansuy, D; Zeldin, DC | 1 |
| Abdel-Rahman, AA; Leffler, KE | 1 |
| Bressan, GC; da Silva, EQG; de Almeida Lima, GD; de Melo Agripino, J; de Oliveira Mendes, TA; de Oliveira, LL; de Paiva, JC; de Souza, APM; Fietto, JLR; Machado-Neves, M; Mendes, FC; Moreira, GA; Santos, MR; Silva, LVG; Silva-Júnior, A; Teixeira, RR | 1 |
| Chen, L; Cui, L; Li, G; Liu, D; Qiu, J; Song, X; Sun, Y; Wang, C; Wang, J | 1 |
| Abo-Dya, NE; Alahmdi, MI; Aljoundi, A; Elamin, G; Soliman, MES | 1 |
| Hill, BT; Hosking, LK | 1 |
Reviews
6 review(s) available for arginine and piperidines
| Article | Year |
|---|---|
Cystinuria.
Topics: Adolescent; Adult; Arginine; Biological Transport; Chemical Phenomena; Chemistry; Cystine; Cystinuria; Female; Heterozygote; Homocysteine; Homozygote; Humans; Jejunum; Kidney Tubules; Lysine; Male; Middle Aged; Ornithine; Penicillamine; Piperidines; Pyrrolidines | 1968 |
Inhibitor binding to thrombin: x-ray crystallographic studies.
Topics: Amino Acid Sequence; Antithrombins; Arginine; Binding Sites; Crystallography, X-Ray; Dipeptides; Hirudins; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Sulfonamides; Thrombin | 1993 |
Modulating platelet function with selective thrombin inhibitors.
Topics: Administration, Oral; Adult; Animals; Antithrombins; Arginine; Blood Platelets; Boron Compounds; Clinical Trials as Topic; Dogs; Drug Evaluation, Preclinical; Glycine; Hirudin Therapy; Hirudins; Humans; Naphthalenes; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Recombinant Proteins; Sulfonamides; Thrombin | 1996 |
Thrombin inhibitor design.
Topics: Anticoagulants; Antithrombins; Arginine; Binding Sites; Dipeptides; Drug Design; Humans; Models, Molecular; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Sulfonamides; Thrombin | 1998 |
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data.
Topics: Angina, Unstable; Antithrombins; Arginine; Glycine; Heparin; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Survival Rate; Thrombin | 2002 |
Selective methodologies for the synthesis of biologically active piperidinic compounds.
Topics: Alkaloids; Arginine; Chemistry; Dioxoles; Paroxetine; Pipecolic Acids; Piperidines; Pyrrolidines; Sulfonamides | 2005 |
Other Studies
88 other study(ies) available for arginine and piperidines
| Article | Year |
|---|---|
Proceedings: Animal experiments of a new synthetic thrombin-inhibitor, dansyl-arginine-methyl-piperidine amide.
Topics: Animals; Arginine; Cattle; Dansyl Compounds; Fibrinogen; Piperidines; Rabbits; Thrombin | 1975 |
Proceedings: A series of extremely potent thrombin-inhibitors newly synthetized.
Topics: Arginine; Dansyl Compounds; Humans; Piperidines; Thrombin | 1975 |
Role of lipoxygenase and cytochrome P-450 in production of endothelium-derived relaxing factors in canine femoral veins.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arginine; Benzoquinones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Femoral Vein; In Vitro Techniques; Lipoxygenase Inhibitors; Masoprocol; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; omega-N-Methylarginine; Piperidines; Proadifen | 1992 |
[Influences of hypercholesterolemia on the vessel function of isolated rat thoracic aorta].
Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Arginine; Body Weight; Cholesterol, Dietary; Endothelium, Vascular; Hypercholesterolemia; In Vitro Techniques; Male; Muscle, Smooth, Vascular; omega-N-Methylarginine; Phenylephrine; Piperidines; Pyrimidinones; Rats; Rats, Inbred Strains; Vasoconstriction | 1992 |
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
Topics: Amidines; Amino Acid Sequence; Animals; Antithrombins; Arginine; Benzamidines; Binding Sites; Cattle; Crystallography; Dipeptides; Fibrinolytic Agents; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Pipecolic Acids; Piperidines; Protein Conformation; Structure-Activity Relationship; Sulfonamides; Thrombin | 1992 |
Inhibition of endothelium-dependent vasorelaxation by arginine analogues: a pharmacological analysis of agonist and tissue dependence.
Topics: Acetylcholine; Alkylation; Animals; Aorta, Thoracic; Arginine; Glyburide; In Vitro Techniques; Indomethacin; Jugular Veins; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Parasympatholytics; Piperidines; Rabbits; Receptors, Muscarinic; Receptors, Serotonin; Serotonin Antagonists | 1992 |
Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
Topics: Amino Acid Chloromethyl Ketones; Antithrombins; Arginine; Benzamidines; Binding Sites; Dipeptides; Humans; Models, Molecular; Pipecolic Acids; Piperidines; Stereoisomerism; Sulfonamides; Thrombin; Trypsin | 1991 |
Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piper
Topics: Animals; Antithrombins; Arginine; Binding Sites; Cattle; Computer Graphics; Crystallography; Dipeptides; Humans; In Vitro Techniques; Models, Molecular; Models, Structural; Molecular Conformation; Pipecolic Acids; Piperidines; Protein Binding; Structure-Activity Relationship; Sulfonamides; Thrombin; Trypsin; Trypsin Inhibitors; X-Ray Diffraction | 1990 |
Stimulus-secretion coupling of arginine-induced insulin release. Uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets.
Topics: Amino Acids; Animals; Arginine; Calcium Radioisotopes; Cations; Glucose; Homoarginine; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Ornithine; Piperidines; Potassium; Rats; Rubidium Radioisotopes; Transaminases | 1989 |
In vitro stimulation of insulin release by non-metabolizable, transport-specific amino acids.
Topics: Amino Acids; Animals; Arginine; Biological Transport; Carbon Isotopes; Extracellular Space; Glucose; Guanine; In Vitro Techniques; Insulin; Islets of Langerhans; Kinetics; Mannitol; Mice; Piperidines; Polycyclic Compounds; Receptors, Drug; Stereoisomerism; Sucrose; Tritium | 1971 |
Amino acid stimulation of alkali-metal-independent ATP cleavage by an Ehrlich cell membrane preparation.
Topics: Adenosine Triphosphatases; Amino Acids; Animals; Antimetabolites; Arginine; Carcinoma, Ehrlich Tumor; Cell Membrane; Glycine; Gramicidin; Kinetics; Leucine; Oligomycins; Ornithine; Ouabain; Piperidines; Potassium; Sodium; Valinomycin | 1973 |
Triphosphate spin-label studies of allosteric interactions in hemoglobin.
Topics: Adenosine Triphosphate; Allosteric Regulation; Arginine; Asparagine; Aspartic Acid; Australia; Binding Sites; Cyanides; Electron Spin Resonance Spectroscopy; Ferricyanides; Glycerophosphates; Hemoglobins; Hemoglobins, Abnormal; Humans; Kinetics; Leucine; Maryland; Mathematics; Models, Biological; Mutation; Phosphoric Acids; Piperidines; Protein Binding; Protein Conformation; Spin Labels | 1973 |
Stimulation of insulin and glucagon release in the dog by a nonmetabolizable arginine analog.
Topics: Amidines; Amino Acids; Animals; Arginine; Dogs; Female; Glucagon; Heptoses; Injections, Intravenous; Insulin; Ketoses; Mannose; Piperidines | 1974 |
Failure to induce tumors in Swiss mice after concurrent administration of amino acids and sodium nitrite.
Topics: Adenoma; Animals; Arginine; Carcinogens; Female; Hydroxyproline; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrites; Nitroso Compounds; Piperidines; Proline; Pyrrolidines | 1972 |
Amino acids and insulin release in vivo.
Topics: Amino Acids; Animals; Arginine; Blood Glucose; Chlorpropamide; Cycloheptanes; Diabetes Mellitus; Dietary Proteins; Dogs; Glucagon; Glucose; Heptoses; Humans; Hypoglycemia; Insulin; Leucine; Pancreas; Piperidines; Time Factors | 1972 |
Intestinal absorption of oligopeptides in cystinuria.
Topics: Adult; Amino Acids; Animals; Arginine; Caseins; Cystinuria; Dipeptides; Glycine; Homozygote; Humans; In Vitro Techniques; Intestinal Absorption; Jejunum; Lysine; Piperidines; Pyrrolidines; Rats | 1971 |
Intestinal absorption of lysine in cystinuric dogs.
Topics: Amino Acids; Animals; Arginine; Cystine; Cystinuria; Dogs; Intestinal Absorption; Lysine; Piperidines; Pyrrolidines | 1965 |
Comparative studies on thrombin inhibitors in experimental microthrombosis.
Topics: 4-Aminobenzoic Acid; Animals; Arginine; Dipeptides; Female; Fibrinogen; Hirudins; Kinetics; Lung; Male; Microcirculation; para-Aminobenzoates; Piperidines; Rats; Rats, Inbred Strains; Thrombin; Thrombosis | 1983 |
Comparison of plasma levels and excretory routes between No. 189 and No. 407, potent thrombin inhibitors.
Topics: Administration, Oral; Animals; Arginine; Dipeptides; Dogs; Infusions, Parenteral; Injections, Intravenous; Liver; Male; Piperidines; Rabbits; Rats; Sulfonamides; Thrombin | 1980 |
K+ channel openers produce epithelium-dependent relaxation of the guinea-pig trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Benzopyrans; Cromakalim; Epithelium; Guinea Pigs; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea; Vasoactive Intestinal Peptide | 1995 |
Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilatation in the hamster cheek pouch microvasculature in vivo.
Topics: Animals; Arginine; Arterioles; Cheek; Cricetinae; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Tachykinins; Vasoconstriction; Vasodilation | 1994 |
Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon.
Topics: Animals; Apamin; Arginine; Atropine; Colon; Dose-Response Relationship, Drug; Guanethidine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin B; Nitric Oxide; Nitroarginine; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-3; Stereoisomerism; Substance P; Tetrodotoxin | 1994 |
Contribution of vascular nitric oxide to basal blood pressure in conscious spontaneously hypertensive rats and normotensive Wistar Kyoto rats.
Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Captopril; Endothelium, Vascular; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentolinium Tartrate; Piperidines; Quinolones; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1995 |
Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase.
Topics: Amidines; Amino Acid Oxidoreductases; Arginine; Chlorobenzoates; Chromatography, Gas; Chromatography, High Pressure Liquid; Hot Temperature; Luminescent Measurements; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Piperidines | 1993 |
Block of endothelin-1-induced release of thromboxane A2 from the guinea pig lung and nitric oxide from the rabbit kidney by a selective ETB receptor antagonist, BQ-788.
Topics: Animals; Arginine; Blood Pressure; Eicosanoids; Endothelin Receptor Antagonists; Endothelins; Female; Guinea Pigs; In Vitro Techniques; Kidney; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Rabbits; Receptors, Endothelin; Renal Circulation; Thromboxane A2 | 1994 |
Neurokinin (NK2) receptors mediate nonadrenergic noncholinergic contractile responses to electrical stimulation and resiniferatoxin in guinea pig trachea.
Topics: Airway Resistance; Animals; Arginine; Benzamides; Diterpenes; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurotoxins; NG-Nitroarginine Methyl Ester; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Tetrodotoxin; Trachea | 1994 |
Neurogenic inhibition of duodenal and jejunal motility in the anaesthetized rat.
Topics: Animals; Arginine; Duodenum; Gastrointestinal Motility; Jejunum; Male; Morphine; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Sprague-Dawley; Sympatholytics; Vagotomy | 1994 |
Bronchodilatation of guinea-pig perfused bronchioles induced by the H3-receptor for histamine: role of epithelium.
Topics: Acetylcholine; Animals; Anticonvulsants; Arginine; Bronchi; Bronchodilator Agents; Epithelium; Female; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; In Vitro Techniques; Indomethacin; Male; Methylhistamines; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Papaverine; Perfusion; Piperidines; Prostaglandins; Receptors, Histamine H3; Tranylcypromine | 1993 |
In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation Tests; Boron; Bridged Bicyclo Compounds; Cells, Cultured; Dipeptides; Hirudins; Humans; Kinetics; Male; Oligopeptides; Pipecolic Acids; Piperidines; Platelet Activation; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin | 1993 |
Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Arginine; Base Sequence; Binding Sites; Cell Line; Cloning, Molecular; Dizocilpine Maleate; DNA Primers; Excitatory Amino Acid Antagonists; Genetic Variation; Humans; Kidney; Kinetics; Macromolecular Substances; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperidines; Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spermidine; Transfection | 1996 |
Endothelin-1 synthesis and receptor-mediated activity in porcine lymph vessels.
Topics: Analysis of Variance; Animals; Arginine; Bronchi; Endothelin Receptor Antagonists; Endothelins; Endothelium, Lymphatic; Enzyme Inhibitors; Immunohistochemistry; In Vitro Techniques; Lymphatic System; Mediastinum; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Piperidines; Receptor, Endothelin A; Receptors, Endothelin; Swine; Trachea | 1996 |
Effect of SR 142801 on nitric oxide-dependent and independent responses to tachykinin NK3 receptor agonists in isolated guinea-pig colon.
Topics: Animals; Arginine; Colon; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P | 1995 |
A histamine H2 receptor antagonist, roxatidine, stimulates mucus secretion and synthesis by cultured rabbit gastric mucosal cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Male; Mucus; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Rabbits | 1995 |
Functionality map analysis of the active site cleft of human thrombin.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Arginine; Binding Sites; Dipeptides; Humans; Models, Molecular; Molecular Probes; Molecular Sequence Data; Molecular Structure; Pipecolic Acids; Piperidines; Protein Conformation; Serine Proteinase Inhibitors; Software; Sulfonamides; Thrombin | 1996 |
Effects of inogatran, a new low-molecular-weight thrombin inhibitor, in rat models of venous and arterial thrombosis, thrombolysis and bleeding time.
Topics: Animals; Antithrombins; Arginine; Aspirin; Bleeding Time; Disease Models, Animal; Fibrinolytic Agents; Glycine; Heparin; Male; Molecular Weight; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombolytic Therapy; Thrombophlebitis; Thrombosis | 1996 |
Reduction of the pressor response to nicotine in the guinea pigs by a histamine (H3) agonist is attenuated by an inhibitor of nitric oxide synthesis.
Topics: Adrenalectomy; Animals; Arginine; Blood Pressure; Cimetidine; Guinea Pigs; Heart Rate; Histamine; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; NG-Nitroarginine Methyl Ester; Nicotine; Nitric Oxide Synthase; Piperidines | 1996 |
Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway.
Topics: Animals; Arginine; Cells, Cultured; Cyclic GMP; Glutamic Acid; Guanylate Cyclase; Hippocampus; Interferon-gamma; Lipopolysaccharides; Neuroprotective Agents; Nitric Oxide Synthase; Piperidines; Rats; Stereoisomerism; Thiazoles | 1996 |
A comparison of heuristic search algorithms for molecular docking.
Topics: Algorithms; Arginine; Azepines; Binding Sites; Computer Simulation; Dipeptides; HIV Protease; Ligands; Macromolecular Substances; Methotrexate; Models, Molecular; Neuraminidase; Pipecolic Acids; Piperidines; Protein Binding; Software Design; Structure-Activity Relationship; Sulfonamides; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thrombin | 1997 |
Inhibition of thrombin generation in plasma by inhibitors of factor Xa.
Topics: Animals; Anticoagulants; Arginine; Arthropod Proteins; Cattle; Dipeptides; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Hirudins; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Molecular Structure; Naphthalenes; Partial Thromboplastin Time; Peptides; Pipecolic Acids; Piperidines; Propionates; Rabbits; Recombinant Proteins; Serine Proteinase Inhibitors; Sulfonamides; Sulfones; Thrombin; Thromboplastin | 1997 |
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycine; Hemodynamics; Heparin; Hirudin Therapy; Hirudins; Kinetics; Male; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 1997 |
YM-60828, a novel factor Xa inhibitor: separation of its antithrombotic effects from its prolongation of bleeding time.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Bleeding Time; Dalteparin; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin; Male; Naphthalenes; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time.
Topics: Animals; Anticoagulants; Arginine; Arteriovenous Shunt, Surgical; Bleeding Time; Blood Proteins; Dalteparin; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin; In Vitro Techniques; Male; Naphthalenes; Partial Thromboplastin Time; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombophlebitis; Thrombosis | 1998 |
Comparative studies of an orally-active factor Xa inhibitor, YM-60828, with other antithrombotic agents in a rat model of arterial thrombosis.
Topics: Administration, Oral; Animals; Anticoagulants; Antithrombin III; Arginine; Carotid Artery Thrombosis; Disease Models, Animal; Factor Xa Inhibitors; Heparin; Infusions, Intravenous; Naphthalenes; Pipecolic Acids; Piperidines; Rats; Sulfonamides | 1998 |
BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis--comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban.
Topics: Animals; Anticoagulants; Arginine; Arteries; Glycine; Heparin; Hirudins; Humans; Infusions, Intravenous; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Veins | 1998 |
Effect of a synthetic factor Xa inhibitor, YM-60828, on blood vessel patency in combination with a thrombolytic agent and on blood loss from the operation site in a rat model of arterial thrombosis.
Topics: Animals; Anticoagulants; Arginine; Blood Loss, Surgical; Carotid Arteries; Carotid Artery Thrombosis; Drug Evaluation, Preclinical; Hemorrhage; Heparin; Male; Naphthalenes; Pipecolic Acids; Piperidines; Rats; Recurrence; Reperfusion; Serine Proteinase Inhibitors; Sulfonamides; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator | 1998 |
An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors.
Topics: Animals; Arginine; CHO Cells; Cricetinae; Dizocilpine Maleate; Dopamine Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Iodine Radioisotopes; Piperidines; Point Mutation; Receptors, N-Methyl-D-Aspartate | 1998 |
Endothelial factors and autoregulation during pressure changes in isolated newborn piglet cerebral arteries.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cerebral Arteries; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Homeostasis; In Vitro Techniques; Indomethacin; Large-Conductance Calcium-Activated Potassium Channels; NG-Nitroarginine Methyl Ester; Oligopeptides; Peptides, Cyclic; Piperidines; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Pressure; Swine; Tetraethylammonium | 1998 |
A comparative SAR study of thrombin receptor derived non peptide mimetics: importance of phenyl/guanidino proximity for activity.
Topics: Arginine; Drug Design; Humans; Models, Molecular; Molecular Conformation; Molecular Mimicry; Oligopeptides; Peptides; Phenylalanine; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Structure-Activity Relationship | 1998 |
Role of NO and endothelin in hemoglobin-induced pulmonary vasoconstriction.
Topics: Animals; Arginine; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Female; Hemoglobins; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oligopeptides; Peptides, Cyclic; Piperidines; Pulmonary Circulation; Rabbits; Vasoconstriction | 1998 |
The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin.
Topics: Antithrombins; Area Under Curve; Arginine; Azetidines; Benzylamines; Binding Sites; Dipeptides; Fluorescence; Glycine; Humans; Kinetics; Molecular Weight; Pipecolic Acids; Piperidines; Spectrometry, Fluorescence; Spectrophotometry; Sulfonamides; Thrombin | 1998 |
Nitric oxide limits the eicosanoid-dependent bronchoconstriction and hypotension induced by endothelin-1 in the guinea-pig.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Antihypertensive Agents; Arginine; Blood Pressure; Bradykinin; Bronchoconstriction; Cyclooxygenase Inhibitors; Drug Synergism; Eicosanoids; Endothelin-1; Endothelins; Enzyme Inhibitors; Female; Guinea Pigs; Hypotension; In Vitro Techniques; Indomethacin; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Peptide Fragments; Perfusion; Piperidines; Thromboxane A2; Vasoconstrictor Agents | 1999 |
Role of nitric oxide in regulation of renal sympathetic nerve activity during hemorrhage in conscious rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine; Blood Pressure; Consciousness; Enzyme Inhibitors; Heart Rate; Hemorrhage; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 1999 |
Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.
Topics: Animals; Antithrombins; Arginine; Cattle; Drug Design; Humans; Injections, Intravenous; Injections, Subcutaneous; Models, Molecular; Pipecolic Acids; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Thrombin; Thrombosis | 1999 |
Effects of endothelin-1 and nitric oxide on glucokinase activity in isolated rat hepatocytes.
Topics: Animals; Arginine; Cells, Cultured; Cyclic GMP; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Glucokinase; Glucose; Glycogen; Kinetics; Liver; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley | 2000 |
Initiation of phase III contractions in the jejunum by atropine, hexamethonium and xylocaine in conscious dogs.
Topics: Acetylcholine; Animals; Anti-Arrhythmia Agents; Arginine; Atropine; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Consciousness; Dogs; Enteric Nervous System; Enzyme Inhibitors; Gastrointestinal Motility; Hexamethonium; Indoles; Injections, Intra-Arterial; Jejunum; Lidocaine; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Parasympatholytics; Peptide Fragments; Piperidines; Postprandial Period; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sulfonamides; Tetrodotoxin | 2000 |
Lack of tPA significantly affects antithrombotic therapy by a GPIIb/IIIa antagonist, but not by a thrombin inhibitor in mice.
Topics: Animals; Arginine; Bleeding Time; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Mice; Mice, Knockout; Pipecolic Acids; Piperazines; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides; Thrombin; Thrombolytic Therapy; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2000 |
Nitric oxide-induced cGMP accumulation in the mouse bladder is not related to smooth muscle relaxation.
Topics: Animals; Arginine; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Mice; Mice, Inbred BALB C; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Phosphodiesterase Inhibitors; Piperazines; Piperidines; Purines; Quinazolines; Sildenafil Citrate; Sulfones; Urethra; Urinary Bladder | 2000 |
Antithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals.
Topics: Animals; Anticoagulants; Antithrombin III; Arginine; Bleeding Time; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Isoquinolines; Macaca fascicularis; Male; Partial Thromboplastin Time; Peptide Hydrolases; Pipecolic Acids; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrahydroisoquinolines; Thrombosis | 2001 |
A short synthesis of argatroban. a potent selective thrombin inhibitor.
Topics: Antithrombins; Arginine; Enzyme Inhibitors; Pipecolic Acids; Piperidines; Sensitivity and Specificity; Sulfonamides | 2001 |
Modification of Arg-13 of mu-conotoxin GIIIA with piperidinyl-Arg analogs and their relation to the inhibition of sodium channels.
Topics: Amino Acid Sequence; Animals; Arginine; Circular Dichroism; Conotoxins; Male; Molecular Sequence Data; Muscle Contraction; Nuclear Magnetic Resonance, Biomolecular; Piperidines; Rats; Rats, Wistar; Sodium Channel Blockers | 2001 |
Effects of intracavernous administration of adrenomedullin on erectile function in rats.
Topics: Adrenomedullin; Animals; Arginine; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Erectile Dysfunction; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penile Erection; Peptides; Phosphodiesterase Inhibitors; Piperidines; Quinazolines; Rats; Rats, Wistar | 2001 |
Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice.
Topics: alpha-2-Antiplasmin; Animals; Arginine; Bleeding Time; Blood Coagulation; Carotid Artery Injuries; Endothelium, Vascular; Mice; Mice, Inbred C57BL; Mice, Knockout; Pipecolic Acids; Piperazines; Piperidines; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Serine Proteinase Inhibitors; Sulfonamides; Thrombin; Thrombin Time; Thrombosis; Vascular Patency | 2002 |
Functional group interactions of a 5-HT3R antagonist.
Topics: Animals; Arginine; Benzimidazoles; Benzyl Compounds; Cell Line; Humans; Kidney; Mice; Mutagenesis, Site-Directed; Nitrogen; Patch-Clamp Techniques; Piperazine; Piperazines; Piperidines; Protein Binding; Protein Interaction Mapping; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Structure-Activity Relationship; Tryptophan; Tyrosine | 2002 |
Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats.
Topics: Adenosine Triphosphate; Administration, Intravesical; Amides; Animals; Arginine; Benzamides; Benzophenones; Female; Hexamethonium; Nerve Fibers; Neurons, Afferent; Piperidines; Purinergic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Reflex; Urinary Bladder; Urination; Urodynamics | 2002 |
Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals.
Topics: Animals; Anticoagulants; Arginine; Blood Coagulation; Dogs; Factor Xa Inhibitors; Haplorhini; Humans; Male; Mice; Models, Animal; Pipecolic Acids; Piperidines; Rabbits; Rats; Rats, Wistar; Serine Endopeptidases; Sulfonamides | 2003 |
Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats.
Topics: Animals; Arginine; Cerebral Infarction; Citrulline; Corpus Striatum; Disease Models, Animal; Ischemic Attack, Transient; Male; Microdialysis; Neuroprotective Agents; Nitric Oxide; Piperidines; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Treatment Outcome | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
THE HYDROLYSIS OF ARGININE.
Topics: Ammonia; Arginine; Chromatography; Hydrochloric Acid; Hydrolysis; Hydroxides; Ion Exchange Resins; Ornithine; Piperidines; Research | 1965 |
Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis.
Topics: Anticoagulants; Arginine; Blood Platelets; Cells, Cultured; Enzyme Inhibitors; Factor Xa Inhibitors; Hemostasis; Humans; Naphthalenes; Partial Thromboplastin Time; Pipecolic Acids; Piperidines; Platelet Activation; Propionates; Prothrombin Time; Pyridines; Sulfonamides; Tetrahydroisoquinolines; Thrombin | 2004 |
Enhanced cardiovascular alteration and Fos expression induced by central salt loading in a conscious rat transgenic for the metallothionein-vasopressin fusion gene.
Topics: Animals; Animals, Genetically Modified; Antidiuretic Hormone Receptor Antagonists; Arginine; Brain; Cardiovascular System; Consciousness; Immunohistochemistry; Injections, Intraventricular; Male; Metallothionein; Oncogene Proteins v-fos; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Recombinant Fusion Proteins; Saline Solution, Hypertonic; Sodium Chloride; Vasopressins | 2005 |
Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro.
Topics: Animals; Arginine; Bleeding Time; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; In Vitro Techniques; Partial Thromboplastin Time; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Prothrombin; Rabbits; Sulfonamides; Thrombin; Thrombosis | 2006 |
Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
Topics: Arginine; Crystallography, X-Ray; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Molecular Structure; Nitric Oxide Synthase Type I; Piperidines; Pyrrolidines; Structure-Activity Relationship | 2007 |
Role of dorsal hippocampal cannabinoid receptors and nitric oxide in anxiety like behaviours in rats using the elevated plus-maze test.
Topics: Analgesics; Animals; Anxiety; Arginine; Benzoxazines; Cannabinoids; Enzyme Inhibitors; Hippocampus; Male; Microinjections; Morpholines; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Stereotaxic Techniques | 2007 |
Membrane-bound peptides from V-ATPase subunit a do not interact with an indole-type inhibitor.
Topics: Acrylamide; Amino Acid Sequence; Amino Acids; Arginine; Fluorescence Resonance Energy Transfer; Indoles; Lipid Bilayers; Lipids; Membrane Proteins; Molecular Sequence Data; Peptides; Phosphatidylcholines; Phosphatidylglycerols; Piperidines; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharomyces cerevisiae; Spectrometry, Fluorescence; Spectrophotometry; Tryptophan; Vacuolar Proton-Translocating ATPases | 2008 |
Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways.
Topics: Animals; Arginine; Cannabinoid Receptor Modulators; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Dronabinol; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glucocorticoids; Glutamic Acid; GTP-Binding Proteins; Guanosine Diphosphate; Hypothalamus; In Vitro Techniques; Male; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Piperidines; Pyrans; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction; Synapses; Synaptic Transmission; Thionucleotides; Valine | 2009 |
Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.
Topics: Analysis of Variance; Animals; Animals, Inbred Strains; Anticonvulsants; Arachidonic Acids; Arginine; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures | 2009 |
Muscarinic receptor-mediated nitric oxide release in a K562 erythroleukaemia cell line.
Topics: Arginine; Carbachol; Chromatography, High Pressure Liquid; Citrulline; Dose-Response Relationship, Drug; Humans; K562 Cells; Microdialysis; Muscarinic Agonists; Muscarinic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Piperidines; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tropicamide | 2009 |
Seizure susceptibility alteration through 5-HT(3) receptor: modulation by nitric oxide.
Topics: Animals; Anticonvulsants; Arginine; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Granisetron; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Piperidines; Receptors, Serotonin, 5-HT3; Seizures; Serotonin Antagonists | 2010 |
Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa.
Topics: Animals; Arginine; Blood Coagulation; Drug Synergism; Factor Xa; Factor Xa Inhibitors; Guanidines; Humans; Male; Naphthalenes; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin | 2010 |
Remifentanil preconditioning reduces hepatic ischemia-reperfusion injury in rats via inducible nitric oxide synthase expression.
Topics: Analgesics, Opioid; Animals; Arginine; Blotting, Western; Cell Survival; Cytokines; Disease Models, Animal; Ischemic Preconditioning; Lipid Peroxidation; Liver; Liver Diseases; Male; Naloxone; Narcotic Antagonists; Nitric Oxide Synthase; Piperidines; Rats; Rats, Sprague-Dawley; Remifentanil; Reperfusion Injury; Transaminases | 2011 |
Soluble Epoxide Hydrolase Pharmacological Inhibition Ameliorates Experimental Acute Pancreatitis in Mice.
Topics: Amylases; Animals; Arginine; Ceruletide; Disease Models, Animal; Epoxide Hydrolases; Gene Expression Regulation; Interleukin-1beta; Interleukin-6; Lipase; MAP Kinase Signaling System; Mice; Pancreatitis; Phenylurea Compounds; Piperidines; Tumor Necrosis Factor-alpha | 2015 |
R59949, a diacylglycerol kinase inhibitor, inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells.
Topics: Animals; Arginine; Biological Transport; Cell Membrane; Cells, Cultured; Cycloheximide; Diacylglycerol Kinase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Interleukin-1beta; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Synthase Type II; Piperidines; Quinazolinones; Rats, Wistar | 2017 |
Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.
Topics: Arginine; Butyrophenones; Catalytic Domain; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Humans; Hydrogen Bonding; Hydroxylation; Molecular Docking Simulation; Molecular Structure; Mutation; Piperidines; Protein Conformation; Substrate Specificity | 2018 |
Restoration of Adiponectin-Connexin43 Signaling Mitigates Myocardial Inflammation and Dysfunction in Diabetic Female Rats.
Topics: Adiponectin; Animals; Arginine; Connexin 43; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Estradiol; Estrogen Receptor alpha; Female; Heme Oxygenase (Decyclizing); Hypertrophy, Left Ventricular; Ovariectomy; Piperidines; Rats, Wistar; Receptors, Adiponectin; Receptors, G-Protein-Coupled; Signal Transduction; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Immunomodulatory activity of trifluoromethyl arylamides derived from the SRPK inhibitor SRPIN340 and their potential use as vaccine adjuvant.
Topics: Adjuvants, Immunologic; Adjuvants, Vaccine; Animals; Antibodies, Neutralizing; Antiviral Agents; Arginine; Dipeptides; Immunity; Mice; Niacinamide; Piperidines; Protein Isoforms; Protein Serine-Threonine Kinases; RNA Splicing Factors; Serine; Vaccines | 2022 |
Application and prospect of quasi-targeted metabolomics in age-related hearing loss.
Topics: Acetylcholine; Amino Acids; Animals; Arginine; Chromatography, High Pressure Liquid; Coenzyme A; gamma-Aminobutyric Acid; Histamine; Methionine; Mice; Mice, Inbred C57BL; Piperidines; Presbycusis; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2022 |
Battling BTK mutants with noncovalent inhibitors that overcome Cys481 and Thr474 mutations in Waldenström macroglobulinemia therapy: structural mechanistic insights on the role of fenebrutinib.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Amino Acids; Arginine; Drug Resistance, Neoplasm; Humans; Mutation; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridones; Pyrimidines; Solvents; Waldenstrom Macroglobulinemia | 2022 |
Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance.
Topics: Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Flunarizine; Humans; Leukemia, T-Cell; Piperidines; Quinidine; Teniposide; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |