Page last updated: 2024-09-03

amdoxovir and zidovudine

amdoxovir has been researched along with zidovudine in 6 studies

Compound Research Comparison

Studies
(amdoxovir)
Trials
(amdoxovir)
Recent Studies (post-2010)
(amdoxovir)
Studies
(zidovudine)
Trials
(zidovudine)
Recent Studies (post-2010) (zidovudine)
335210,1801,3991,188

Protein Interaction Comparison

ProteinTaxonomyamdoxovir (IC50)zidovudine (IC50)
Thymidine kinase, cytosolicHomo sapiens (human)3
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.6633
Protease Human immunodeficiency virus 10.015

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asif, G; Chu, CK; Delinsky, D; Hurwitz, SJ; McClure, HM; Narayanasamy, J; Obikhod, A; Schinazi, RF1
Asif, G; Fromentin, E; Hurwitz, SJ; Schinazi, RF; Tharnish, PM1
Amblard, F; Bassit, LC; Bondana, L; Cho, JH; Coats, SJ; Detorio, MA; Montero, C; Schinazi, RF1
Borroto-Esoda, K; Chong, Y; Chu, CK; Furman, PA; Schinazi, RF1
Asif, G; Fromentin, E; Hurwitz, SJ; Obikhod, A; Schinazi, RF1
Kivel, NM; Mathew, J; Murphy, RL; Ochoa, C; Pascual, ML; Schinazi, RF; Tharnish, P; Zala, C1

Trials

2 trial(s) available for amdoxovir and zidovudine

ArticleYear
Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Adult; Anti-HIV Agents; Dioxolanes; Drug Administration Schedule; Drug Interactions; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Purine Nucleosides; Reverse Transcriptase Inhibitors; Treatment Outcome; Young Adult; Zidovudine

2010
Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals.
    Antiviral therapy, 2010, Volume: 15, Issue:2

    Topics: Adult; Anti-HIV Agents; Dioxolanes; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Purine Nucleosides; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Viral Load; Young Adult; Zidovudine

2010

Other Studies

4 other study(ies) available for amdoxovir and zidovudine

ArticleYear
Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Dioxolanes; Female; Half-Life; HIV-1; Injections, Intravenous; Macaca mulatta; Mass Spectrometry; Metabolic Clearance Rate; Molecular Structure; Reference Standards; Reproducibility of Results; Thymine

2007
Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.
    Bioorganic & medicinal chemistry, 2014, Dec-01, Volume: 22, Issue:23

    Topics: Adenosine; Amides; Antiviral Agents; Dioxolanes; Dose-Response Relationship, Drug; Hepatitis B virus; HIV-1; Microbial Sensitivity Tests; Nucleosides; Phosphoric Acids; Prodrugs; Structure-Activity Relationship

2014
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach.
    Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:2

    Topics: Anti-HIV Agents; Binding Sites; Dioxolanes; Drug Resistance; Guanosine; HIV-1; Lamivudine; Models, Molecular; Mutation, Missense; Protein Binding; Purine Nucleosides; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Zidovudine

2002
Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Nov-01, Volume: 877, Issue:29

    Topics: Antiviral Agents; Chromatography, Liquid; Dioxolanes; Guanine; Humans; Purine Nucleosides; Reproducibility of Results; Tandem Mass Spectrometry; Zidovudine

2009