amdoxovir and zidovudine
amdoxovir has been researched along with zidovudine in 6 studies
Compound Research Comparison
| Studies (amdoxovir) | Trials (amdoxovir) | Recent Studies (post-2010) (amdoxovir) | Studies (zidovudine) | Trials (zidovudine) | Recent Studies (post-2010) (zidovudine) |
|---|---|---|---|---|---|
| 33 | 5 | 2 | 10,180 | 1,399 | 1,188 |
Protein Interaction Comparison
| Protein | Taxonomy | amdoxovir (IC50) | zidovudine (IC50) |
|---|---|---|---|
| Thymidine kinase, cytosolic | Homo sapiens (human) | 3 | |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | 0.6633 | |
| Protease | Human immunodeficiency virus 1 | 0.015 |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Asif, G; Chu, CK; Delinsky, D; Hurwitz, SJ; McClure, HM; Narayanasamy, J; Obikhod, A; Schinazi, RF | 1 |
| Asif, G; Fromentin, E; Hurwitz, SJ; Schinazi, RF; Tharnish, PM | 1 |
| Amblard, F; Bassit, LC; Bondana, L; Cho, JH; Coats, SJ; Detorio, MA; Montero, C; Schinazi, RF | 1 |
| Borroto-Esoda, K; Chong, Y; Chu, CK; Furman, PA; Schinazi, RF | 1 |
| Asif, G; Fromentin, E; Hurwitz, SJ; Obikhod, A; Schinazi, RF | 1 |
| Kivel, NM; Mathew, J; Murphy, RL; Ochoa, C; Pascual, ML; Schinazi, RF; Tharnish, P; Zala, C | 1 |
Trials
2 trial(s) available for amdoxovir and zidovudine
| Article | Year |
|---|---|
Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.
Topics: Adult; Anti-HIV Agents; Dioxolanes; Drug Administration Schedule; Drug Interactions; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Purine Nucleosides; Reverse Transcriptase Inhibitors; Treatment Outcome; Young Adult; Zidovudine | 2010 |
Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals.
Topics: Adult; Anti-HIV Agents; Dioxolanes; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Purine Nucleosides; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Viral Load; Young Adult; Zidovudine | 2010 |
Other Studies
4 other study(ies) available for amdoxovir and zidovudine
| Article | Year |
|---|---|
Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys.
Topics: Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Dioxolanes; Female; Half-Life; HIV-1; Injections, Intravenous; Macaca mulatta; Mass Spectrometry; Metabolic Clearance Rate; Molecular Structure; Reference Standards; Reproducibility of Results; Thymine | 2007 |
Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.
Topics: Adenosine; Amides; Antiviral Agents; Dioxolanes; Dose-Response Relationship, Drug; Hepatitis B virus; HIV-1; Microbial Sensitivity Tests; Nucleosides; Phosphoric Acids; Prodrugs; Structure-Activity Relationship | 2014 |
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach.
Topics: Anti-HIV Agents; Binding Sites; Dioxolanes; Drug Resistance; Guanosine; HIV-1; Lamivudine; Models, Molecular; Mutation, Missense; Protein Binding; Purine Nucleosides; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Zidovudine | 2002 |
Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay.
Topics: Antiviral Agents; Chromatography, Liquid; Dioxolanes; Guanine; Humans; Purine Nucleosides; Reproducibility of Results; Tandem Mass Spectrometry; Zidovudine | 2009 |