Compounds > ag 3-5
Page last updated: 2024-09-04

ag 3-5 and capsaicin

ag 3-5 has been researched along with capsaicin in 19 studies

Compound Research Comparison

Studies
(ag 3-5)		Trials
(ag 3-5)		Recent Studies (post-2010)
(ag 3-5)		Studies
(capsaicin)		Trials
(capsaicin)		Recent Studies (post-2010) (capsaicin)
12606611,2386613,410

Protein Interaction Comparison

ProteinTaxonomyag 3-5 (IC50)capsaicin (IC50)
Transient receptor potential cation channel subfamily V member 1Rattus norvegicus (Norway rat)0.019
Lysine-specific histone demethylase 1AHomo sapiens (human)0.6
Bile salt export pumpHomo sapiens (human)10
Cytochrome P450 1A2Homo sapiens (human)3
Prostaglandin G/H synthase 1Homo sapiens (human)2.6755
Transient receptor potential cation channel subfamily V member 1Homo sapiens (human)0.008

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (47.37)29.6817
2010's10 (52.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nilius, B; Owsianik, G; Talavera, K; Voets, T1
Babes, A; Reid, G; Zorzon, D1
Nagao, M; Shimada, S; Ueda, T; Ugawa, S; Yamamura, H1
Fu, Y; Kochukov, MY; McNearney, TA; Westlund, KN1
Brandt, MR; Colburn, RW; D'Andrea, MR; Flores, CM; Lawrence, D; Liu, Y; Lubin, ML; Qin, N; Stone, DJ; Wang, Y1
Ding, Z; Gomez, T; Raffa, RB; Rawls, SM1
Horie, S; Matsumoto, K; Nakamura, T; Penuelas, A; Tashima, K; Tsuchiya, S; Yano, S1
Endo, T; Hayashi, S; Kubo, Y; Nakamura, E; Takeuchi, K1
Cahusac, PM1
Dayanithi, G; Kayano, T; Kitamura, N; Moriya, T; Ozaki, Y; Shibuya, I; Tsutsumi, A1
Anand, P; Anand, U; Otto, WR1
Beltrán, C; Darszon, A; De Blas, G; de la Vega-Beltrán, JL; Gibbs, GM; Martínez-López, P; Monroy, E; O'Bryan, MK; Orta, G; Treviño, CL1
McCoy, ES; Pribisko, AL; Street, SE; Taylor-Blake, B; Zheng, J; Zylka, MJ1
Abdelmessih, S; Böhm, A; Derckx, R; Garreis, F; Khajavi, N; Mergler, S; Polat, OK; Ramesh, N; Reinach, PS; Riechardt, AI; Schmelzer, L; Skosyrski, S1
Horie, S; Takayama, H; Terada, Y; Tominaga, M; Uchida, K; Watanabe, T1
Di Silvio, L; Duggal, AK; Egbuniwe, O; Grant, AD; Grover, S; Mavroudis, A; Renton, T; Yazdi, M1
Khajavi, N; Köhrle, J; Lucius, A; Mergler, S; Reinach, PS; Skrzypski, M; Slavi, N; Strauß, O1
Alvarez de la Rosa, D; Armas-Capote, N; Buckley, ST; Ehrhardt, C; Fischer, H; Harvey, BJ; Huwer, H; Illek, B; Lehr, CM; Schneider-Daum, N; Schwagerus, E; Sladek, S1
Dhandapani, P; Grötzinger, C; Huimann, P; Khajavi, N; Köhrle, J; Ljubojevic, N; Lucius, A; Mergler, S; Reinach, PS1

Reviews

1 review(s) available for ag 3-5 and capsaicin

ArticleYear
Sensing with TRP channels.
    Nature chemical biology, 2005, Volume: 1, Issue:2

    Topics: Animals; Humans; Ligands; Models, Biological; Phylogeny; Temperature; Transient Receptor Potential Channels

2005

Other Studies

18 other study(ies) available for ag 3-5 and capsaicin

ArticleYear
Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor.
    The European journal of neuroscience, 2004, Volume: 20, Issue:9

    Topics: Animals; Ankyrins; Calcium; Calcium Channels; Calcium Signaling; Capsaicin; Cells, Cultured; Cold Temperature; Drug Synergism; Ganglia, Spinal; Ion Channels; Menthol; Mustard Plant; Neoplasm Proteins; Nerve Growth Factor; Neurons, Afferent; Plant Extracts; Plant Oils; Pyrimidinones; Rats; Thermosensing; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels

2004
Icilin activates the delta-subunit of the human epithelial Na+ channel.
    Molecular pharmacology, 2005, Volume: 68, Issue:4

    Topics: Amiloride; Animals; Capsaicin; Epithelial Sodium Channels; Humans; Protons; Pyrimidinones; Sodium Channel Agonists; Sodium Channels; Xenopus laevis

2005
Thermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes.
    American journal of physiology. Cell physiology, 2006, Volume: 291, Issue:3

    Topics: Arthritis, Rheumatoid; Calcium; Calcium Channels; Calcium Signaling; Capsaicin; Cell Line, Tumor; Cells, Cultured; Chondrocalcinosis; Cytosol; Diterpenes; Hot Temperature; Humans; Inflammation; Nerve Tissue Proteins; Pyrimidinones; RNA, Messenger; Synovial Membrane; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels

2006
Attenuated cold sensitivity in TRPM8 null mice.
    Neuron, 2007, May-03, Volume: 54, Issue:3

    Topics: Analysis of Variance; Animals; Behavior, Animal; Calcium; Capsaicin; Cells, Cultured; Cold Temperature; Ganglia, Spinal; Inflammation; Methanol; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurons, Afferent; Pain Measurement; Pyrimidinones; Reaction Time; Thermosensing; TRPM Cation Channels

2007
Differential behavioral effect of the TRPM8/TRPA1 channel agonist icilin (AG-3-5).
    European journal of pharmacology, 2007, Dec-01, Volume: 575, Issue:1-3

    Topics: Animals; Behavior, Animal; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Planarians; Pyrimidinones; Sensory System Agents; Time Factors; TRPM Cation Channels

2007
Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine.
    European journal of pharmacology, 2007, Dec-08, Volume: 576, Issue:1-3

    Topics: Animals; Capsaicin; Disulfides; Gastrointestinal Motility; In Vitro Techniques; Intestines; Isothiocyanates; Male; Menthol; Mice; Pyrimidinones; RNA, Messenger; Sulfinic Acids; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels

2007
Impairment by activation of TRPA1 of gastric epithelial restitution in a wound model using RGM1 cell monolayer.
    Inflammopharmacology, 2007, Volume: 15, Issue:5

    Topics: Animals; Ankyrins; Calcium Channel Agonists; Calcium Channels; Capsaicin; Cell Line; Epithelial Cells; Gastric Mucosa; Isothiocyanates; Menthol; Pyrimidinones; Rats; Temperature; Time Factors; TRPA1 Cation Channel; TRPC Cation Channels; TRPM Cation Channels; TRPV Cation Channels; Wound Healing

2007
Effects of transient receptor potential (TRP) channel agonists and antagonists on slowly adapting type II mechanoreceptors in the rat sinus hair follicle.
    Journal of the peripheral nervous system : JPNS, 2009, Volume: 14, Issue:4

    Topics: Acrolein; Action Potentials; Animals; Ankyrins; Calcium Channels; Camphor; Capsaicin; Evoked Potentials; Hair Follicle; In Vitro Techniques; Isothiocyanates; Male; Mechanoreceptors; Menthol; Physical Stimulation; Pyrimidinones; Rats; Rats, Wistar; Ruthenium Red; Time Factors; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels

2009
Chronic treatment with NGF induces spontaneous fluctuations of intracellular Ca(2+) in icilin-sensitive dorsal root ganglion neurons of the rat.
    The Journal of veterinary medical science, 2010, Volume: 72, Issue:12

    Topics: Animals; Calcium; Capsaicin; Cells, Cultured; Drug Administration Schedule; Ganglia, Spinal; Male; Nerve Growth Factor; Neurons; Pyrimidinones; Rats; Rats, Sprague-Dawley

2010
Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons.
    Molecular pain, 2010, Nov-24, Volume: 6

    Topics: Animals; Antineoplastic Agents; Capsaicin; Cells, Cultured; Cyclic AMP; Drug Interactions; Neurons; Neurotoxicity Syndromes; Organoplatinum Compounds; Oxaliplatin; Pyrimidinones; Rats; Sensory System Agents; TRPM Cation Channels

2010
TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.
    Journal of cellular physiology, 2011, Volume: 226, Issue:6

    Topics: Acrosome Reaction; Animals; Capsaicin; Humans; Ion Channel Gating; Male; Menthol; Mice; Mice, Knockout; Pyrazines; Pyridines; Pyrimidinones; Spermatozoa; Temperature; Testis; TRPM Cation Channels

2011
Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold.
    Neuron, 2013, Apr-10, Volume: 78, Issue:1

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cold Temperature; Diphtheria Toxin; Excitatory Postsynaptic Potentials; Female; Ganglia, Spinal; Gene Expression Regulation; Green Fluorescent Proteins; Histamine; Hot Temperature; In Vitro Techniques; Lectins; Male; Mice; Mice, Transgenic; Neurofilament Proteins; Pruritus; Pyrimidinones; Reaction Time; Receptors, Calcitonin Gene-Related Peptide; Sensory Receptor Cells; Sensory Thresholds; Skin; Sural Nerve; Time Factors; TRPM Cation Channels; TRPV Cation Channels; Ubiquitin Thiolesterase

2013
Calcium regulation by temperature-sensitive transient receptor potential channels in human uveal melanoma cells.
    Cellular signalling, 2014, Volume: 26, Issue:1

    Topics: Benzoxazines; Calcium; Capsaicin; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Ion Channel Gating; Melanoma; Models, Biological; Morpholines; Naphthalenes; Pyrimidinones; Receptor, Cannabinoid, CB1; RNA, Messenger; Temperature; Transient Receptor Potential Channels; Uveal Neoplasms

2014
Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.
    Journal of natural products, 2014, Feb-28, Volume: 77, Issue:2

    Topics: Africa; Alkaloids; Calcium; Capsaicin; Humans; Ibogaine; Menthol; Molecular Structure; Plant Bark; Pyrimidinones; Transient Receptor Potential Channels; Trees; TRPV Cation Channels; Voacanga

2014
TRPA1 and TRPV4 activation in human odontoblasts stimulates ATP release.
    Journal of dental research, 2014, Volume: 93, Issue:9

    Topics: Acetanilides; Acrolein; Adenosine Triphosphate; Calcium Channels; Calcium Signaling; Capsaicin; Cell Culture Techniques; Cell Line; Culture Media, Conditioned; Dental Pulp; Humans; Isothiocyanates; Leucine; Nerve Tissue Proteins; Nociceptors; Odontoblasts; Purines; Pyrimidinones; Sensory System Agents; Sulfonamides; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels

2014
Thyronamine induces TRPM8 channel activation in human conjunctival epithelial cells.
    Cellular signalling, 2015, Volume: 27, Issue:2

    Topics: Calcium; Capsaicin; Cell Line; Conjunctiva; Epithelial Cells; Humans; Interleukin-6; Membrane Potentials; Patch-Clamp Techniques; Pyrimidinones; RNA, Messenger; Thyronines; TRPM Cation Channels; TRPV Cation Channels

2015
Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro.
    Pflugers Archiv : European journal of physiology, 2015, Volume: 467, Issue:11

    Topics: Capsaicin; Diuretics; Epithelial Cells; Epithelial Sodium Channels; Evans Blue; Gene Knockdown Techniques; Humans; Primary Cell Culture; Pulmonary Alveoli; Pyrimidinones; Respiratory Mucosa; Sodium

2015
3-Iodothyronamine increases transient receptor potential melastatin channel 8 (TRPM8) activity in immortalized human corneal epithelial cells.
    Cellular signalling, 2016, Volume: 28, Issue:3

    Topics: Calcium; Capsaicin; Cell Line; Epithelial Cells; Humans; Interleukin-6; Membrane Potentials; Patch-Clamp Techniques; Pyrazines; Pyridines; Pyrimidinones; Thyronines; TRPM Cation Channels; TRPV Cation Channels

2016