Page last updated: 2024-12-10
ro26-4550
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Cross-References
ID Source | ID |
---|---|
PubMed CID | 5288250 |
CHEMBL ID | 419362 |
SCHEMBL ID | 14136720 |
MeSH ID | M0449668 |
Synonyms (15)
Synonym |
---|
bdbm50147974 |
(s)-2-[2-((r)-1-carbamimidoyl-piperidin-3-yl)-acetylamino]-3-(4-phenylethynyl-phenyl)-propionic acid methyl ester |
2-[3-methyl-4-(n-methyl-guanidino)-butyrylamino]-3-(4-phenylethynyl-phenyl)-propionic acid methyl ester |
methyl n-{[(3r)-1-carbamimidoyl-3-piperidinyl]acetyl}-4-(phenylethynyl)-l-phenylalaninate |
1M48 |
DB03453 |
methyl (2s)-2-[[2-[(3r)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate |
NCGC00166396-01 |
ro-264550 |
CHEMBL419362 , |
SCHEMBL14136720 |
methyl n-{[(3r)-1-carbamimidoylpiperidin-3-yl]acetyl}-4-(phenylethynyl)-l-phenylalaninate |
Q27460411 |
PD070751 |
AKOS040749349 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (2)
Inhibition Measurements
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Interleukin-2 receptor subunit alpha | Mus musculus (house mouse) | IC50 (µMol) | 6.0000 | 0.0600 | 3.0300 | 6.0000 | AID91893 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Activation Measurements
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, interleukin-2 | Homo sapiens (human) | Kd | 8.2000 | 8.2000 | 8.2000 | 8.2000 | AID977611 |
Interleukin-2 receptor subunit alpha | Mus musculus (house mouse) | EC50 (µMol) | 100.0000 | 0.0030 | 0.0030 | 0.0030 | AID107966 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Other Measurements
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Bioassays (9)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID91897 | Dissociation constant for mouse Interleukin-2 receptor alpha by SPR assay | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. |
AID107966 | Effective concentration required against phosphorylation of Mammary gland factor/STAT5 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. |
AID700921 | Inhibition of IL2 receptor binding to IL2 alpha receptor by scintillation proximity assay | 2012 | Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6 | Chemical modulators working at pharmacological interface of target proteins. |
AID91893 | Inhibition of mouse Interleukin-2 receptor alpha | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12 | Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. |
AID241068 | Inhibitory concentration against interleukin-2 binding | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Identification of nonpeptidic small-molecule inhibitors of interleukin-2. |
AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2003 | Proceedings of the National Academy of Sciences of the United States of America, Feb-18, Volume: 100, Issue:4 | Binding of small molecules to an adaptive protein-protein interface. |
AID1811 | Experimentally measured binding affinity data derived from PDB | 2003 | Proceedings of the National Academy of Sciences of the United States of America, Feb-18, Volume: 100, Issue:4 | Binding of small molecules to an adaptive protein-protein interface. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (50.00) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 2 (33.33) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 1 (16.67%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (83.33%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |