Page last updated: 2024-11-10

ro26-4550

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID5288250
CHEMBL ID419362
SCHEMBL ID14136720
MeSH IDM0449668

Synonyms (15)

Synonym
bdbm50147974
(s)-2-[2-((r)-1-carbamimidoyl-piperidin-3-yl)-acetylamino]-3-(4-phenylethynyl-phenyl)-propionic acid methyl ester
2-[3-methyl-4-(n-methyl-guanidino)-butyrylamino]-3-(4-phenylethynyl-phenyl)-propionic acid methyl ester
methyl n-{[(3r)-1-carbamimidoyl-3-piperidinyl]acetyl}-4-(phenylethynyl)-l-phenylalaninate
1M48
DB03453
methyl (2s)-2-[[2-[(3r)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate
NCGC00166396-01
ro-264550
CHEMBL419362 ,
SCHEMBL14136720
methyl n-{[(3r)-1-carbamimidoylpiperidin-3-yl]acetyl}-4-(phenylethynyl)-l-phenylalaninate
Q27460411
PD070751
AKOS040749349
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Interleukin-2 receptor subunit alphaMus musculus (house mouse)IC50 (µMol)6.00000.06003.03006.0000AID91893
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, interleukin-2Homo sapiens (human)Kd8.20008.20008.20008.2000AID977611
Interleukin-2 receptor subunit alphaMus musculus (house mouse)EC50 (µMol)100.00000.00300.00300.0030AID107966
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID91897Dissociation constant for mouse Interleukin-2 receptor alpha by SPR assay2004Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
AID107966Effective concentration required against phosphorylation of Mammary gland factor/STAT52004Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
AID700921Inhibition of IL2 receptor binding to IL2 alpha receptor by scintillation proximity assay2012Bioorganic & medicinal chemistry, Mar-15, Volume: 20, Issue:6
Chemical modulators working at pharmacological interface of target proteins.
AID91893Inhibition of mouse Interleukin-2 receptor alpha2004Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
AID241068Inhibitory concentration against interleukin-2 binding2005Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4
Identification of nonpeptidic small-molecule inhibitors of interleukin-2.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2003Proceedings of the National Academy of Sciences of the United States of America, Feb-18, Volume: 100, Issue:4
Binding of small molecules to an adaptive protein-protein interface.
AID1811Experimentally measured binding affinity data derived from PDB2003Proceedings of the National Academy of Sciences of the United States of America, Feb-18, Volume: 100, Issue:4
Binding of small molecules to an adaptive protein-protein interface.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]