Compounds > rb 7040
Page last updated: 2024-09-25

rb 7040

Cross-References

ID SourceID
PubMed CID128739
CHEMBL ID89126
MeSH IDM0142883

Synonyms (8)

Synonym
CHEMBL89126
rb 7040
1-(2-nitroimidazol-1-yl)-3-(2,2,3,3-tetramethylaziridin-1-yl)propan-2-ol
1h-imidazole-1-ethanol, 2-nitro-alpha-((2,2,3,3-tetramethyl-1-aziridinyl)methy)-
rb-7040
105027-76-7
1-(2-nitro-1h-imidazol-1-yl)-3-(2,2,3,3-tetramethylaziridin-1-yl)propan-2-ol
DTXSID40909306

Bioassays (1)

Assay IDTitleYearJournalArticle
AID133777Maximum tolerated dose was determined for compound administered intraperitoneally as a suspension in arachis oil in C3H/He mice1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Synthesis and evaluation of alpha-[[(2-haloethyl)amino]methyl]-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-[(1-aziridinyl)methyl]-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activate
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's4 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol[no description available]medium60
rb 6145[no description available]medium10
misonidazole[no description available]medium50
rb 88716[no description available]medium20
1-(2-nitro-1-imidazoly)-3-(2,3-dimethylaziridino)-2-propanol[no description available]medium40
rsu 1131[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Lung0low10
Cancer of the Lung0low10
Cell Transformation, Neoplastic0low10
EHS Tumor0low10
Experimental Neoplasms0low10
Experimental Sarcoma0low10
Experimental Sarcomas0low10
Lung Cancer0low10
Lung Neoplasms0low10
Neoplasms, Experimental0low10
Neoplasms, Lung0low10
Neoplasms, Pulmonary0low10
Neoplastic Cell Transformation0low10
Neoplastic Transformation, Cell0low10
Pulmonary Cancer0low10
Pulmonary Neoplasms0low10
Sarcoma, Engelbreth-Holm-Swarm0low10
Sarcoma, Experimental0low10
Sarcoma, Jensen0low10
Sarcomas, Experimental0low10
Transformation, Neoplastic Cell0low10
Tumorigenic Transformation0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
Studies with bifunctional bioreductive drugs. II. Cytotoxicity assayed with A-549 lung carcinoma cells of human origin.
Radiation research, Volume: 124, Issue: 1 Suppl		1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: in vivo evaluation in KHT murine sarcomas.
Radiation research, Volume: 124, Issue: 1 Suppl		1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]