Compounds > rb 88716

Page last updated: 2024-11-07

rb 88716

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

RB 88716: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	124273
CHEMBL ID	84038
MeSH ID	M0182235

Synonyms (7)

Synonym
CHEMBL84038
rb 88716
143134-32-1
2-furancarboxamide, 5-nitro-n-(oxyranylmethyl)-
rb-88716
DTXSID70931756
5-nitro-n-[(oxiran-2-yl)methyl]furan-2-carboxamide

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID47690	Cytotoxicity in air (MMT assay).	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins.
AID232995	Differential toxicity expressed as the ratio of C50 (air) to C50 (nitrogen)	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins.
AID44145	Compound was tested for persistent physical or behavioral effects in C3H/He mice	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins.
AID47688	Molar concentration required to give a sensitizer enhancement ratio of 1.6 in hypoxic CHO (V79) cells.	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins.
AID47691	Cytotoxicity in nitrogen (MMT assay).	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis and evaluation of novel electrophilic nitrofuran carboxamides and carboxylates as radiosensitizers and bioreductively activated cytotoxins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	6 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.50 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
lomustine [no description available]	1.98	1	0	N-nitrosoureas; organochlorine compound	alkylating agent; antineoplastic agent
misonidazole Misonidazole: A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.	3.23	6	0
1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol: structure given in first source	3.23	6	0
1-(2-nitro-1-imidazoly)-3-(2,3-dimethylaziridino)-2-propanol [no description available]	3.07	5	0
rb 6145 RB 6145: structure given in first source; prodrug to RSU 1069; PD 144872 is the R-enantiomer of RB 6145	1.97	1	0
rb 7040 [no description available]	2.38	2	0
tirapazamine Tirapazamine: A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.. tirapazamine : A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.	1.98	1	0	aromatic amine; benzotriazines; N-oxide	antibacterial agent; antineoplastic agent; apoptosis inducer

Condition	Indicated	Relationship Strength	Studies	Trials
Carcinoma, Anaplastic [description not available]	0	1.98	1	0
EHS Tumor [description not available]	0	1.98	1	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	0	1.98	1	0
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	0	2.38	2	0
Cancer, Second Primary [description not available]	0	1.98	1	0
Cancer of Lung [description not available]	0	1.97	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	0	1.97	1	0