Compounds > ra xii
Page last updated: 2024-10-15

ra xii

Description

RA XII: structure given in first source; isolated from Rubia cordifolia [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
RubiagenusA plant genus of the family RUBIACEAE. The root is a source of red dyes (madder color and 1,2,4-trihydroxy-9,10-anthracenedione) and ANTHRAQUINONES.[MeSH]RubiaceaeThe Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH]
Rubia cordifoliaspecies[no description available]RubiaceaeThe Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH]

Cross-References

ID SourceID
PubMed CID156599349
MeSH IDM0217519

Synonyms (6)

Synonym
ra-xii
ra xii
bouvardin, 5-(n-methyl-l-tyrosine)-6-(o-beta-d-glucopyranosyl-3-hydroxy-n-methyl-l-tyrosine)-
143343-98-0
5-(n-methyl-l-tyrosine)-6-(o-beta-d-glucopyranosyl-3-hydroxy-n-methyl-l-tyrosine)-bouvardin
DTXSID501347785

Bioavailability

ExcerptReference
" However, RA-XII shows low oral bioavailability in rats due to its poor solubility and low permeability."( Novel amorphous solid dispersion based on natural deep eutectic solvent for enhancing delivery of anti-tumor RA-XII by oral administration in rats.
Bi, Q; Ding, X; Lai, Z; Liu, M; Tan, N; Tong, X; Wang, Z; Zhu, L, 2021)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's1 (9.09)29.6817
2010's5 (45.45)24.3611
2020's4 (36.36)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycosides
[no description available]		2.0110
ra v
RA V: structure given in first source		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Colitis-Associated Cancer
[description not available]		02.4110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.4110
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.		02.4110
Colorectal Cancer
[description not available]		02.6620
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.6620
Benign Neoplasms
[description not available]		02.3110
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.3110
Cancer of Colon
[description not available]		02.3110
Colonic Neoplasms
Tumors or cancer of the COLON.		02.3110
Acute Kidney Failure
[description not available]		02.1710
Acute Kidney Injury
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.		02.1710
Cancer of Liver
[description not available]		02.2110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.2110
Lymph Node Metastasis
[description not available]		02.1110
Experimental Mammary Neoplasms
[description not available]		02.1110
Invasiveness, Neoplasm
[description not available]		02.1110