pedilstatin: from a republic of maldives Pedilanthus sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
pedilstatin : A phorbol ester that is 4-deoxyphorbol in which the hydroxy groups at positions 12 and 13 have been replaced by octa-2,4-dienoyloxy and acetyloxy groups respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 643665 |
| CHEMBL ID | 519593 |
| CHEBI ID | 743 |
| MeSH ID | M0444649 |
| Synonym |
|---|
| (1ar,1bs,4ar,7ar,7br,8r,9r,9as)-9a-acetoxy-7b-hydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1h-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl (2z,4e)-octa-2,4-dienoate |
| CHEBI:743 , |
| 4-deoxy-4alpha-phorbol 13-acetate 12-(2z,4e)-octa-2,4-dienoate |
| 13-o-acetyl-12-o-(z,e)-2,4-octadienoyl-4-desoxyphorbol |
| octa-2,4-dienoic acid 9a-acetoxy-7b-hydroxy-3-hydroxymethyl-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1h-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl ester |
| inchi=1/c30h40o7/c1-7-8-9-10-11-12-24(33)36-27-18(3)29(35)22-13-17(2)25(34)21(22)14-20(16-31)15-23(29)26-28(5,6)30(26,27)37-19(4)32/h9-13,15,18,21-23,26-27,31,35h,7-8,14,16h2,1-6h3/b10-9+,12-11-/t18-,21-,22-,23+,26-,27-,29+,30-/m1/s |
| 2,4-octadienoic acid, (1ar,1bs,4ar,7ar,7br,8r,9r,9as)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-7b-hydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1h-cyclopropa[3,4]benz[1,2-e]azulen-9-yl |
| (1ar,1bs,4ar,7ar,7br,8r,9r,9as)-9a-(acetyloxy)-7b-hydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1h-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl rel-(2z,4e)-octa-2,4 |
| pedilstatin |
| CHEMBL519593 |
| LMPR0104330004 |
| Q27105346 |
| [(1r,2r,6r,10s,11r,13s,14r,15r)-13-acetyloxy-1-hydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] (2z,4e)-octa-2,4-dienoate |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| phorbol ester | Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C. |
| acetate ester | Any carboxylic ester where the carboxylic acid component is acetic acid. |
| primary allylic alcohol | An allylic alcohol in which the carbon atom that links the double bond to the hydroxy group is also attached to two hydrogens. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID335900 | Cytotoxicity against mouse P388 cells | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. |
| AID335898 | Cytotoxicity against human CEM-SS cells assessed as inhibition of cell metabolic activity after 7 days by XTT assay | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. |
| AID335897 | Inhibition of [20-3H]phorbol 12,13-dibutyrate binding to protein kinase C | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. |
| AID335896 | Antiviral activity against HIV1 RF in human CEM-SS cells assessed as cell protection from infection at 2 to 5 uM after 7 days relative to control | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. |
| AID335899 | Antiviral activity against HIV1 RF in human CEM-SS cells assessed as cell protection from infection after 7 days | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.26) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||