pedilstatin and Leukemia-P388

pedilstatin has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for pedilstatin and Leukemia-P388

Article	Year
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. Journal of natural products, 2002, Volume: 65, Issue:9 A new cancer cell growth inhibitor designated pedilstatin (1) was isolated from a Republic of Maldives Pedilanthus sp. The structure was determined to be 13-O-acetyl-12-O-[2'Z,4'E-octadienoyl]-4alpha-deoxyphorbol on the basis of high-resolution mass spectral and 2D NMR assignments. Pedilstatin was found to significantly inhibit growth of the P388 lymphocytic leukemia cell line with an ED(50) of 0.28 microg/mL, to afford, at concentrations of 2-5 microM, protection (to 80%) of human-derived lymphoblastoid CEM-SS cells from infection and cell-killing by HIV-1, and to show inhibition of protein kinase C with a K(i) of 620 +/- 20 nM. Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Cell Survival; Enzyme Inhibitors; Euphorbiaceae; HIV-1; Humans; Indian Ocean Islands; Leukemia P388; Lymphocytes; Mice; Molecular Structure; Phorbols; Plants, Medicinal; Protein Kinase C; Structure-Activity Relationship; Tumor Cells, Cultured	2002

Article

Year

Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.

Journal of natural products, 2002, Volume: 65, Issue:9

A new cancer cell growth inhibitor designated pedilstatin (1) was isolated from a Republic of Maldives Pedilanthus sp. The structure was determined to be 13-O-acetyl-12-O-[2'Z,4'E-octadienoyl]-4alpha-deoxyphorbol on the basis of high-resolution mass spectral and 2D NMR assignments. Pedilstatin was found to significantly inhibit growth of the P388 lymphocytic leukemia cell line with an ED(50) of 0.28 microg/mL, to afford, at concentrations of 2-5 microM, protection (to 80%) of human-derived lymphoblastoid CEM-SS cells from infection and cell-killing by HIV-1, and to show inhibition of protein kinase C with a K(i) of 620 +/- 20 nM.

Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Cell Survival; Enzyme Inhibitors; Euphorbiaceae; HIV-1; Humans; Indian Ocean Islands; Leukemia P388; Lymphocytes; Mice; Molecular Structure; Phorbols; Plants, Medicinal; Protein Kinase C; Structure-Activity Relationship; Tumor Cells, Cultured

2002