papuamine: antineoplastic from an Indonesian sponge Haliclona sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10248478 |
| CHEMBL ID | 3577062 |
| SCHEMBL ID | 3199723 |
| MeSH ID | M0590420 |
| Synonym |
|---|
| papuamine |
| papuamine, (-)- |
| (-)-papuamine |
| unii-6695rbd96k |
| 1h-diindeno(2,1-f:1',2'-l)(1,5)diazacyclotridecine, 2,3,4,4a,5,5a,6,7,8,9,10,10a,11,11a,12,13,14,15,15a,15b,19a,19b-docosahydro-, (4as,5ar,10ar,11as,15ar,15bs,16e,18e,19as,19br)- |
| 6695rbd96k , |
| papuamine [mi] |
| (4as,5ar,10ar,11as,15ar,15bs,16e,18e,19as,19br)-2,3,4,4a,5,5a,6,7,8,9,10,10a,11,11a,12,13,14,15,15a,15b,19a,19b-docosahydro-1h-diindeno(2,1-f:1',2'-1)(1,5)diazacyclotridecine |
| 112455-84-2 |
| SCHEMBL3199723 |
| CHEMBL3577062 |
| J-002780 |
| DTXSID301019061 |
| Q27263982 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Papuamine has a potential as a novel mitochondria-targeting anticancer agent." | ( Papuamine Inhibits Viability of Non-small Cell Lung Cancer Cells by Inducing Mitochondrial Dysfunction. Jung, Y; Lee, HY; Min, HY; Park, KH, 2020) | 3.44 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1225347 | Cytotoxicity against human SF295 cells after 48 hrs by XTT assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Neopetrocyclamines A and B, polycyclic diamine alkaloids from the sponge Neopetrosia cf exigua. |
| AID1635084 | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by WST-1 assay | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Haliclonadiamine Derivatives and 6-epi-Monanchorin from the Marine Sponge Halichondria panicea Collected at Iriomote Island. |
| AID1635082 | Antimycobacterial activity against Mycobacterium smegmatis NBRC 3207 at 10 ug/disc after 2 days by paper disc method | 2016 | Journal of natural products, Apr-22, Volume: 79, Issue:4 | Haliclonadiamine Derivatives and 6-epi-Monanchorin from the Marine Sponge Halichondria panicea Collected at Iriomote Island. |
| AID1225346 | Cytotoxicity against human A498 cells after 48 hrs by XTT assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Neopetrocyclamines A and B, polycyclic diamine alkaloids from the sponge Neopetrosia cf exigua. |
| AID1225345 | Cytotoxicity against human UO31 cells after 48 hrs by XTT assay | 2015 | Journal of natural products, Mar-27, Volume: 78, Issue:3 | Neopetrocyclamines A and B, polycyclic diamine alkaloids from the sponge Neopetrosia cf exigua. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.90) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||