ohmyungsamycin-a has been researched along with ecumicin* in 2 studies
2 other study(ies) available for ohmyungsamycin-a and ecumicin
| Article | Year |
|---|---|
Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A.
Ohmyungsamycin A and ecumicin are structurally related cyclic depsipeptide natural products that possess activity against Topics: Animals; Antitubercular Agents; Bacterial Proteins; Biological Products; Depsipeptides; Molecular Chaperones; Mycobacterium tuberculosis; Peptides, Cyclic; Zebrafish | 2022 |
Total Synthesis and Antimycobacterial Activity of Ohmyungsamycin A, Deoxyecumicin, and Ecumicin.
The ohmyungsamycin and ecumicin natural product families are structurally related cyclic depsipeptides that display potent antimycobacterial activity. Herein the total syntheses of ohmyungsamycin A, deoxyecumicin, and ecumicin are reported, together with the direct biological comparison of members of these natural product families against Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB). The synthesis of each of the natural products employed a solid-phase strategy to assemble the linear peptide precursor, involving a key on-resin esterification and an optional on-resin dimethylation step, before a final solution-phase macrolactamization between the non-proteinogenic N-methyl-4-methoxy-l-tryptophan amino acid and a bulky N-methyl-l-valine residue. The synthetic natural products possessed potent antimycobacterial activity against Mtb with MIC Topics: Antitubercular Agents; Humans; Mycobacterium tuberculosis; Peptides, Cyclic; Tuberculosis | 2020 |