nsc 14575 profile

Cross-References

Synonym
9-ethyl mercaptopurine
ai3-50230
brn 0162062
6h-purine-6-thione, 9-ethyl-1,9-dihydro-
9-ethyl-1,9-dihydro-6h-purine-6-thione
wln: t56 bn dn fn hnj d2 ish
9h-purine-6(1h)-thione, 9-ethyl-
nsc 14575
9h-purine-6-thiol, 9-ethyl-
5427-20-3
nsc14575
9-ethyl-6-mercaptopurine
nsc-14575
9-ethyl-6-mp
purine, 9-ethyl-6-mercapto-
9-ethylpurine-6-thiol
9-ethyl-3h-purine-6-thione
AKOS006271454
CHEMBL2203444
SCHEMBL2116000
v24r30q68z ,
5-26-13-00225 (beilstein handbook reference)
unii-v24r30q68z
9-ethyl-9h-purine-6[1h]-thione
APDNCRBSYUOIKC-UHFFFAOYSA-N
DTXSID20202625
9-ethyl-1h-purine-6(9h)-thione
Q27291437
PD069589

Assay ID	Title	Year	Journal	Article
AID712403	Cytotoxicity against CHO cells	2012	ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12	Small Molecule Ligands For Active Targeting Of TrkC-expressing Tumor Cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (83.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (16.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
mercaptopurine Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.	3.2	6	aryl thiol; purines; thiocarbonyl compound	anticoronaviral agent; antimetabolite; antineoplastic agent
thioguanine anhydrous Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.	1.96	1	2-aminopurines	anticoronaviral agent; antimetabolite; antineoplastic agent
9-(n-butyl)-6-thioguanine [no description available]	1.96	1

Condition	Relationship Strength	Studies
Leucocythaemia [description not available]	2.34	2
Leukemia, Lymphocytic [description not available]	1.94	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.34	2
Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	1.94	1
EHS Tumor [description not available]	1.96	1