Page last updated: 2024-12-09

necrostatin-7

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

necrostatin-7: a necroptosis inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1239801
CHEMBL ID514242
SCHEMBL ID12682782
MeSH IDM0525664

Synonyms (27)

Synonym
HMS621M06 ,
necrotatin-7
CHEMBL514242
necrostatin-7
AKOS001738191
351062-08-3
mfcd02140208
STK763743 ,
(5z)-5-{[3-(4-fluorophenyl)-1h-pyrazol-4-yl]methylidene}-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
(5z)-5-[[5-(4-fluorophenyl)-1h-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
nec-7
5-[[3-(4-fluorophenyl)-1h-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone
SMJGLNVGTJLIRV-KBEFMPHXSA-N
5'-[3-(4-fluoro-phenyl)-1h-pyrazol-4-ylmethylene]-2'-imino-[2,3']bithiazolyl-4'-one
(5z)-5-([3-(4-fluorophenyl)-1h-pyrazol-4-yl]methylene)-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one #
SCHEMBL12682782
sr-01000531116
SR-01000531116-1
DTXSID40361283
J-019941
5-((3-(4-fluorophenyl)-1h-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one
nec 7
necrostatin7
necrostatin 7
nec7
CS-0064314
HY-117200
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID387464Inhibition of TNF-alpha-induced necroptosis in FADD-deficient human Jurkat cells2008Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 18.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index18.31 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (18.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]