Page last updated: 2024-12-08
l 163255
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
L 163255: a growth hormone secretagogue; RN given for (R)-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 196958 |
| CHEMBL ID | 107751 |
| SCHEMBL ID | 5015356 |
| MeSH ID | M0267498 |
Synonyms (13)
| Synonym |
|---|
| l 163255 |
| l-163255 |
| CHEMBL107751 |
| 2-amino-2-methyl-n-[(2r)-1-(1-methylsulfonylspiro[2h-indole-3,4'-piperidine]-1'-yl)-1-oxo-5-phenylpentan-2-yl]propanamide |
| l-163,255 |
| 159634-54-5 |
| l 163,255 |
| n-(1-(1,2-dihydro-1-methanesulfonylspiro(3h-indole-3,4'-piperidine-1'-yl)carbonyl)-4-phenylbutyl)-2-amino-2-methylpropanamide hydrochloride |
| SCHEMBL5015356 |
| DTXSID50166701 |
| PD161188 |
| AKOS040752293 |
| propanamide, 2-amino-n-[(1r)-1-[[1,2-dihydro-1-(methylsulfonyl)spiro[3h-indole-3,4'-piperidin]-1'-yl]carbonyl]-4-phenylbutyl]-2-methyl- |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (4)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID209316 | Compound was measured for IGF-1 increases in swine on days 4, 7, 10, and 14 approximately | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17 | Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential. |
| AID209317 | Compound was measured for elevated mean plasma IGF-1 (insulin like growth factor) concentrations in Swine | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17 | Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential. |
| AID61096 | Loss of body weight in dog is evaluated after compound was administered perorally to dog at a dose 5 mg/kg, once daily (control (wt) = 1.13+/-0.19) | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17 | Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential. |
| AID228874 | The intrinsic potency studied extensively in animals | 1998 | Journal of medicinal chemistry, Aug-13, Volume: 41, Issue:17 | Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (13)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.71
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.71) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (23.08%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (76.92%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||