Compounds > indanazoline
Page last updated: 2024-11-06

indanazoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Indanazoline is a sympathomimetic amine that acts as an α-adrenergic agonist. Its synthesis involves several steps, starting with the condensation of 2-indanone with ethyl cyanoacetate followed by a series of reactions. Indanazoline has been studied for its potential therapeutic applications, particularly in the treatment of nasal congestion, hypotension, and glaucoma. It exerts vasoconstrictive effects, leading to nasal decongestion and an increase in blood pressure. However, its clinical use is limited due to its adverse effects such as headache, insomnia, and tachycardia. Further research is ongoing to investigate its potential in other areas, including its role in neuroprotection and its ability to modulate the immune system.'

indanazoline: RN given refers to parent cpd; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID65979
CHEMBL ID2104824
CHEBI ID134863
SCHEMBL ID151815
MeSH IDM0089655

Synonyms (31)

Synonym
indanazolin
CHEBI:134863
indanazoline
n-(2,3-dihydro-1h-inden-4-yl)-4,5-dihydro-1h-imidazol-2-amine
40507-78-6
D08075
indanazoline (inn)
unii-l0u38ehd86
1h-imidazol-2-amine, n-(2,3-dihydro-1h-inden-4-yl)-4,5-dihydro-
l0u38ehd86 ,
indanazolina [spanish]
2-(4-indanylamino)-2-imidazoline
indanazolina [inn-spanish]
indanazoline [inn]
indanazolinum
indanazolina
indanazolinum [latin]
indanazolinum [inn-latin]
n-(2-imidazolin-2-yl)-n-(4-indanyl)amine
CHEMBL2104824
indanazoline [who-dd]
indanazoline [mi]
SCHEMBL151815
(4,5-dihydro-1h-imidazol-2-yl)-4-indanylamine
DTXSID40193521
AKOS027378075
HY-U00075
CS-6599
FT-0710425
DB13827
Q27282563

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The description of the quality of the active ingredient N-(2-imidazolin-2-yl)-N-(4-indanyl)amine monohydrochloride (indanazoline, Farial) and the dosage form allows a pharmaceutical evaluation."( [On the galenical development of a nose spray from N-(2-imidazolin-2-yl)-N-(4-indanyl)amine monohydrochloride (indanazoline) (author's transl)].
Dechow, HJ; Lämmerhirt, K; Pich, CH; Schikarski, M, 1980)		0.68
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
indanes
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (14.29%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
xylometazoline
xylometazoline: RN given refers to parent cpd; structure		3.3411alkylbenzene
phentolamine
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.. phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.		1.9510imidazoles;
phenols;
substituted aniline;
tertiary amino compound		alpha-adrenergic antagonist;
vasodilator agent
ConditionIndicatedRelationship StrengthStudiesTrials
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9510
Hay Fever
[description not available]		01.9610
Nasal Catarrh
[description not available]		01.9610
Rhinitis, Allergic, Nonseasonal
[description not available]		01.9610
Rhinitis, Allergic, Seasonal
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.		01.9610
Rhinitis
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.		01.9610
Rhinitis, Allergic, Perennial
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.		01.9610