hupehenine: commercially available antitussive and expectorant from Fritillaria hupehensis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Fritillaria | genus | A plant genus of the family LILIACEAE. Members of this genus produce imperialine, a steroidal alkaloid which acts at muscarinic receptors.[MeSH] | Liliaceae | A monocot family within the order Liliales.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 14240934 |
| MeSH ID | M0526712 |
| Synonym |
|---|
| S9475 |
| 98243-57-3 |
| hupehenine |
| delavine |
| AC-34288 |
| Q-100911 |
| AKOS030573536 |
| CS-0008943 |
| HY-N0413 |
| mfcd07781416 |
| (1r,2s,6s,9s,10r,11r,14s,15s,17r,18s,20s,23r,24s)-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosane-17,20-diol |
| HMS3887G07 |
| AS-56266 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The validated method was applied to the pharmacokinetic study of verticinone in rats after a single oral administration of 1 mg/kg." | ( Development and validation of a liquid chromatography-mass spectrometry method for the determination of verticinone in rat plasma and its application to pharmacokinetic study. Chen, H; Liang, Y; Peng, Y; Sun, J; Wang, G; Wu, J; Wu, X; Zhang, P, 2010) | 0.36 |
| " The method was successfully applied to a pharmacokinetic study of hupehenine after either oral or intravenous administration." | ( Determination and validation of hupehenine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study. Huang, X; Lin, Y; Liu, Z; Ma, J; Wang, S; Wang, X; Wen, C; Yang, S; Zhou, Y, 2015) | 0.94 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " For the first time, the bioavailability of hupehenine was reported as 13." | ( Determination and validation of hupehenine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study. Huang, X; Lin, Y; Liu, Z; Ma, J; Wang, S; Wang, X; Wen, C; Yang, S; Zhou, Y, 2015) | 0.96 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||