Chlormethoxynil is a herbicide that was developed in the 1960s and used for weed control in a variety of crops. It is a member of the chlorophenoxy herbicides, which are known for their broad-spectrum activity. It was commonly used to control broadleaf weeds in cereals and other crops, but its use has declined in recent years due to concerns about its environmental impact and potential for resistance development. Chlormethoxynil is absorbed by plants through the roots and leaves, and it works by disrupting plant growth hormones. The mode of action of chlormethoxynil is related to auxin, a plant growth hormone that promotes cell division and elongation. It is a potent inhibitor of the synthesis of auxin, leading to distorted growth and ultimately death of the plant. Research on chlormethoxynil has focused on its environmental fate, potential for resistance development, and impact on non-target organisms. Chlormethoxynil is a relatively persistent herbicide in the environment, and it can accumulate in soil and water. It is also known to be toxic to aquatic organisms, and it has been linked to declines in fish populations in some areas. In addition, chlormethoxynil can be harmful to birds and other wildlife. Due to these concerns, the use of chlormethoxynil has been restricted in many countries.'
| ID Source | ID |
|---|---|
| PubMed CID | 36250 |
| CHEMBL ID | 2268939 |
| CHEBI ID | 82192 |
| SCHEMBL ID | 38653 |
| MeSH ID | M0153667 |
| Synonym |
|---|
| einecs 251-266-1 |
| ether, (2,4-dichlorophenyl) (3-methoxy-4-nitrophenyl) |
| chlormethoxynil |
| chlomethoxyfen |
| chlomethoxyfen [bsi:iso] |
| ccris 7157 |
| ekkusagoni |
| x-52 |
| 4-(2,4-dichlorophenoxy)-2-methoxy-1-nitrobenzene |
| 5-(2,4-dichlorophenoxy)-2-nitroanisole |
| diphenex |
| brn 2158908 |
| chlomethoxynil |
| 2,4-dichlorophenyl 3'-methoxy-4'-nitrophenyl ether |
| 2,4-dichlorophenyl 3-methoxy-4-nitrophenyl ether |
| 32861-85-1 |
| 2,4-dichloro-1-(3-methoxy-4-nitrophenoxy)benzene |
| C19066 |
| vo5437p1a2 , |
| unii-vo5437p1a2 |
| chebi:82192 , |
| CHEMBL2268939 |
| chlomethoxyfen [iso] |
| SCHEMBL38653 |
| DTXSID6058055 |
| benzene, 2,4-dichloro-1-(3-methoxy-4-nitrophenoxy)- |
| Q15726992 |
| AKOS040751150 |
| Class | Description |
|---|---|
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.58) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (11.11%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (88.89%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||