Compounds > caprazamycin b
Page last updated: 2024-10-14

caprazamycin b

Description

caprazamycin B: anti-tuberculosis lipo-nucleoside antibiotic from Streptomyces sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11332272
CHEMBL ID4542478
MeSH IDM0453394

Synonyms (9)

Synonym
caprazamycin b
327164-11-4
(2s,5s,6s)-2-[(s)-[(2s,3r,4s,5r)-5-(aminomethyl)-3,4-dihydroxyoxolan-2-yl]oxy-[(2s,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-1,4-dimethyl-6-[(3s)-14-methyl-3-[(3s)-3-methyl-5-oxo-5-[(2s,3r,4r,5s,6s)-3,4,5-trimethoxy-6-methylox
EX-A7040
CHEMBL4542478
CS-0167304
HY-N9425
caprazamycin
AKOS040758046
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID1603499Antibacterial activity against Mycobacterium avium2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603503Antibacterial activity against Staphylococcus aureus2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603496Antibacterial activity against Mycobacterium vaccae2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603508Antibacterial activity against Escherichia coli2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1724069Antimycobacterial activity against Mycobacterium tuberculosis H37Rv2020Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
Uridine natural products: Challenging targets and inspiration for novel small molecule inhibitors.
AID1603495Antibacterial activity against Mycobacterium phlei2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603505Antibacterial activity against Bacillus subtilis2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603506Antibacterial activity against Bacillus cereus2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603494Antibacterial activity against Mycobacterium smegmatis2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603507Antibacterial activity against Corynebacterium bovis2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603504Antibacterial activity against Bacillus anthracis2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603497Antibacterial activity against Mycobacterium fortuitum2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603500Antibacterial activity against Mycobacterium intracellulare2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603501Antibacterial activity against Mycobacterium bovis2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603502Antibacterial activity against Micrococcus luteus2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
AID1603498Antibacterial activity against Mycobacterium tuberculosis2019European journal of medicinal chemistry, Jun-01, Volume: 171Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (22.22%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (77.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
uridine
[no description available]		3.1450uridinesdrug metabolite;
fundamental metabolite;
human metabolite
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.05101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
4-cyclohexylaniline
4-cyclohexylaniline: analgesic activity		3.3510
oxazolidine
oxazolidine: structure given in first source		2.0510oxazolidine
caprazamycin c
caprazamycin C: an antituberculosis antibiotic; isolated from Streptomyces; structure in first source		3.1450
ribose
ribopyranose : The pyranose form of ribose.		2.0310D-ribose;
ribopyranose
caprazol
caprazol: an antituberculosis antibiotic; isolated from Streptomyces; structure in first source		2.4320
cpzen-45
CPZEN-45: caprazamycin derivative; structure in first source		4.2420
ConditionIndicatedRelationship StrengthStudiesTrials