Page last updated: 2024-11-07

alpha-Cyclohexylmandelic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID97700
CHEMBL ID1333063
CHEBI ID165187
SCHEMBL ID198082

Synonyms (89)

Synonym
AC-16189
4335-77-7
nsc28945
nsc-28945
benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-
kl-007-m1
einecs 224-380-4
nsc 28945
(+-)-cyclohexylphenylglycolic acid
rcc 32
alpha-phenylcyclohexaneglycolic acid
alpha-cyclohexyl-alpha-hydroxybenzeneacetic acid
acide phenylcyclohexylhydroxyacetique [french]
nsc 93969
hexahydrobenzilic acid
phenyl-cyclohexylglycolic acid
cyclohexaneglycolic acid, alpha-phenyl-
OPREA1_543150
nsc93969
nsc-93969
CHEMDIV2_000672
STK364404
cyclohexyl(hydroxy)phenylacetic acid
cyclohexyl-hydroxy-phenyl-acetic acid
alpha-cyclohexylmandelic acid
smr000518539
MLS001211653
AKOS000300197
2-cyclohexyl-2-hydroxy-2-phenylacetic acid
CHEBI:165187
HMS1370O12
FT-0665346
FT-0665345
NCGC00245367-01
cyclohexylphenylglycolic acid
alpha-cyclohexyl-dl-mandelic acid
C2393
cyclohexylmandelic acid
acide phenylcyclohexylhydroxyacetique
unii-qh762w903u
qh762w903u ,
CCG-106579
2-cyclohexyl-2-hydroxy-phenylacetic acid
cyclohexyl mandelic acid
a-cyclohexylmandelic acid
alpha cyclohexylmandelic acid
a-cyclohexyl-a-hydroxyphenyl acetic acid
2-cyclohexyl-2-phenylglycolic acid
2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid
HMS2833F08
2-cyclohexylmandelic acid
FT-0635236
AM20040469
rcc-32
benzeneacetic acid, .alpha.-cyclohexyl-.alpha.-hydroxy-
cpga
.alpha.-phenylcyclohexylglycolic acid
oxybutynin hydrochloride impurity d [ep impurity]
.alpha.-cyclohexyl-.alpha.-phenylglycolic acid
.alpha.-cyclohexyl-dl-mandelic acid
SCHEMBL198082
SY011590
mfcd00194543
phenylcyclohexylglycolic acid
CHEMBL1333063
AKOS016842341
AE-641/03292035
cyclohexylphenyl glycolic acid
YTRNSQPXEDGWMR-UHFFFAOYSA-N
cyclohexyl (hydroxy) phenyl acetic acid
2-cyclohexyl-2-hydroxy-2-phenyl acetic acid
alpha-cyclohexylphenylglycolic acid
cyclohexyl-hydroxy-phenylacetic acid
W-106234
DS-1292
50896-04-3
alpha-cyclohexylmandelic acid, 97%
|a inverted exclamation mark-cyclohexylmandelic acid
(rs)-2-cyclohexyl-2-hydroxy-2-phenylacetic acid (phenylcyclohexylglycolic acid)
benzeneacetic acid,a-cyclohexyl-a-hydroxy-
BCP22302
BRD-A49752073-001-07-3
benzeneacetic acid, a-cyclohexyl-a-hydroxy-
Q27287264
EN300-7392541
CS-0156519
DTXSID50863369
2-cyclohexyl-2-hydroxy-2-phenylaceticacid
Z1741965610
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzenesAny benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency1.33710.003245.467312,589.2998AID2517
ATAD5 protein, partialHomo sapiens (human)Potency0.16350.004110.890331.5287AID504467
thioredoxin glutathione reductaseSchistosoma mansoniPotency89.12510.100022.9075100.0000AID485364
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1215579Activity of human recombinant CES2 expressed in baculovirus-infected High Five insect cells assessed as enzyme-mediated compound formation formation treated with oxybutynin at 10 uM for 30 mins by HPLC analysis in presence of 10 uM CES1 inhibitor NDGA2012Drug metabolism and disposition: the biological fate of chemicals, May, Volume: 40, Issue:5
Conclusive identification of the oxybutynin-hydrolyzing enzyme in human liver.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.35 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]