Compounds > 1-(2-fluoro-5-nitrophenyl)-3-phenylurea
Page last updated: 2024-09-28

1-(2-fluoro-5-nitrophenyl)-3-phenylurea

Cross-References

ID SourceID
PubMed CID832988
CHEMBL ID1489283
CHEBI ID121266

Synonyms (14)

Synonym
n-(2-fluoro-5-nitrophenyl)-n'-phenylurea
MLS000680561
smr000268747
n-{2-fluoro-5-nitrophenyl}-n'-phenylurea
AN-329/40487560
1-(2-fluoro-5-nitrophenyl)-3-phenylurea
STK033464
CHEBI:121266
AKOS000488443
HMS2524C23
CHEMBL1489283
Q27209798
sr-01000231641
SR-01000231641-1

Drug Classes (1)

ClassDescription
ureas
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency2.23870.044717.8581100.0000AID485294
LuciferasePhotinus pyralis (common eastern firefly)Potency37.93300.007215.758889.3584AID588342
glp-1 receptor, partialHomo sapiens (human)Potency22.38720.01846.806014.1254AID624417
WRNHomo sapiens (human)Potency11.22020.168331.2583100.0000AID651768
TDP1 proteinHomo sapiens (human)Potency29.09290.000811.382244.6684AID686978
importin subunit beta-1 isoform 1Homo sapiens (human)Potency125.89205.804836.130665.1308AID540263
snurportin-1Homo sapiens (human)Potency125.89205.804836.130665.1308AID540263
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency35.48130.00798.23321,122.0200AID2551
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency0.14130.00419.962528.1838AID2675
lamin isoform A-delta10Homo sapiens (human)Potency22.38720.891312.067628.1838AID1487
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
allantoic acid[no description available]low00ureasmouse metabolite;
plant metabolite
allantoin[no description available]low00imidazolidine-2,4-dione;
ureas		Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite;
vulnerary
oxaluric acid[no description available]low002-oxo monocarboxylic acid;
ureas		Escherichia coli metabolite
pd 173074[no description available]low00aromatic amine;
biaryl;
dimethoxybenzene;
pyridopyrimidine;
tertiary amino compound;
ureas		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
fibroblast growth factor receptor antagonist
carbamazepine[no description available]low00dibenzoazepine;
ureas		analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic
carbamazepine epoxide[no description available]low00dibenzoazepine;
epoxide;
ureas		allergen;
drug metabolite;
marine xenobiotic metabolite
dimorpholamine[no description available]low00morpholines;
ureas
hydroxymethyltolbutamide[no description available]low00benzyl alcohols;
sulfonamide;
ureas		metabolite
hydroxyurea[no description available]low00one-carbon compound;
ureas		antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent
1,3-dicyclohexylurea[no description available]low00ureas
carbamylhydrazine[no description available]low00carbohydrazide;
monocarboxylic acid amide;
one-carbon compound;
ureas
n-phenylurea[no description available]low00ureas
1,3-dimethylurea[no description available]low00ureas
ethylene urea[no description available]low00imidazolidinone;
ureas
carbarson[no description available]low00ureas
carbamol[no description available]low00ureas
dulcin[no description available]low00ureas
hydantoic acid[no description available]low00monocarboxylic acid;
N-acylglycine;
ureas		rat metabolite;
xenobiotic metabolite
neburon[no description available]low00ureas
methylurea[no description available]low00ureas
1,1,3,3-tetramethylurea[no description available]low00ureashuman metabolite
monolinuron[no description available]low00ureas
siduron[no description available]low00ureas
metobromuron[no description available]low00ureas
imidocarb[no description available]low00ureasantiprotozoal drug
chlormerodrin[no description available]low00organomercury compound;
ureas		diagnostic agent;
diuretic
chlorbromuron[no description available]low00ureas
carbuterol[no description available]low00ureas
iprodione[no description available]low00benzenes;
dichlorophenyl dicarboximide fungicide;
imidazole fungicide;
imidazolidine-2,4-dione;
ureas		antifungal agrochemical;
nematicide
imidazolidinyl urea[no description available]low00ureasantimicrobial agent
dymron[no description available]low00ureas
thidiazuron[no description available]low00ureas
lidamidine[no description available]low00ureas
buprofezin[no description available]low00thiadiazinane;
ureas
zileuton[no description available]low001-benzothiophenes;
ureas		anti-asthmatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor;
leukotriene antagonist;
non-steroidal anti-inflammatory drug
glycoluril[no description available]low00azabicycloalkane;
ureas
homocitrulline[no description available]low00amino acid zwitterion;
L-lysine derivative;
non-proteinogenic L-alpha-amino acid;
ureas		human metabolite;
mouse metabolite
talinolol[no description available]low00ureas
mecloralurea[no description available]low00ureas
dmp 323[no description available]low00diazepanone;
ureas		anti-HIV agent;
metabolite
amperozide[no description available]low00diarylmethane;
monofluorobenzenes;
N-alkylpiperazine;
secondary carboxamide;
ureas		anxiolytic drug;
dopamine uptake inhibitor;
geroprotector;
second generation antipsychotic;
serotonergic antagonist
prochloraz[no description available]low00amide fungicide;
aromatic ether;
conazole fungicide;
imidazole fungicide;
imidazoles;
trichlorobenzene;
ureas		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic
biocytin[no description available]low00azabicycloalkane;
L-alpha-amino acid zwitterion;
L-lysine derivative;
monocarboxylic acid amide;
non-proteinogenic L-alpha-amino acid;
thiabicycloalkane;
ureas		mouse metabolite
10-hydroxycarbamazepine[no description available]low00carboxamide;
dibenzoazepine;
ureas		anticonvulsant;
drug allergen;
sodium channel blocker
carglumic acid[no description available]low00N-acyl-L-glutamic acid;
ureas		carbamylphosphate synthetase I activator;
orphan drug
ici 89406[no description available]low00ureas
ns 1608[no description available]low00ureas
1,3-bis(3-chlorophenyl)urea[no description available]low00ureas
allophanic acid[no description available]low00ureas
birb 796[no description available]low00aromatic ether;
morpholines;
naphthalenes;
pyrazoles;
ureas		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
immunomodulator
eslicarbazepine acetate[no description available]low00acetate ester;
carboxamide;
dibenzoazepine;
ureas		anticonvulsant;
drug allergen
9-mercaptodethiobiotin[no description available]low00imidazolidinone;
monocarboxylic acid;
thiol;
ureas		Escherichia coli metabolite
1,1,3,3-tetraphenylurea[no description available]low00ureas
N-cyclooctylurea[no description available]low00ureas
1-(4-chlorophenyl)-3-(2-ethoxyphenyl)urea[no description available]low00ureas
2-[[[4-(methylthio)anilino]-oxomethyl]amino]benzamide[no description available]low00ureas
pnu 120596[no description available]low00ureas
N-[4-[[(3,4-dimethylanilino)-oxomethyl]amino]phenyl]-N-methylacetamide[no description available]low00ureas
1-(4-methyl-1,3-benzothiazol-2-yl)-3-[3-(methylthio)phenyl]urea[no description available]low00ureas
1-(2,6-dichlorophenyl)-3-(6-methyl-3-pyridinyl)urea[no description available]low00ureas
ritonavir[no description available]low001,3-thiazoles;
carbamate ester;
carboxamide;
L-valine derivative;
ureas		antiviral drug;
environmental contaminant;
HIV protease inhibitor;
xenobiotic
xv 638[no description available]low001,3-thiazoles;
benzamides;
diazepanone;
diol;
secondary alcohol;
secondary carboxamide;
ureas		HIV protease inhibitor
1-[[(5-hex-1-ynyl-2-furanyl)-oxomethyl]amino]-3-phenylurea[no description available]low00ureas
1-(3-chlorophenyl)-3-[4-[4-morpholinyl(oxo)methyl]phenyl]urea[no description available]low00ureas
1-(4-cyanophenyl)-3-[1-[(4-methoxyphenyl)methyl]-2-oxo-3-pyridinyl]urea[no description available]low00ureas
N3-(2,3-dimethylphenyl)-N1-(2-methoxyphenyl)piperidine-1,3-dicarboxamide[no description available]low00ureas
1-[5-[[anilino(oxo)methyl]amino]-1,3-dimethyl-2-oxo-4-imidazolidinyl]-3-phenylurea[no description available]low00ureas
1-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea[no description available]low00thiadiazoles;
ureas
1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea[no description available]low00thiadiazoles;
ureas
1-(4-hydroxyphenyl)-3-[1,1,1-trifluoro-2-(trifluoromethyl)butan-2-yl]urea[no description available]low00ureas
2-[[anilino(oxo)methyl]amino]-4,5-dimethyl-3-thiophenecarboxamide[no description available]low00ureas
1-(1,3-benzothiazol-2-yl)-3-phenylurea[no description available]low00ureas
1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-3-(4-chlorophenyl)urea[no description available]low00ureas
1-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)urea[no description available]low00ureas
1-(3,5-dichlorophenyl)-3-phenylurea[no description available]low00ureas
1-(4,5-dihydrothiazol-2-yl)-3-phenylurea[no description available]low00ureas
1-(4-methoxyphenyl)-3-(6-methyl-2-pyridinyl)urea[no description available]low00ureas
1-cyclohexyl-3-(2-ethylphenyl)urea[no description available]low00ureas
2-[[anilino(oxo)methyl]amino]-N-(2-furanylmethyl)benzamide[no description available]low00ureas
1-(4-methoxyphenyl)-1-methyl-3-(1-methyl-5-benzotriazolyl)urea[no description available]low00ureas
1-(4-methoxyphenyl)-3-(2-methyl-1,3-benzoxazol-5-yl)urea[no description available]low00ureas
1-cyclohexyl-3-(3-ethylphenyl)urea[no description available]low00ureas
1-(2,4-dichlorophenyl)-3-(1-methyl-3-pyrazolyl)urea[no description available]low00ureas
1-[tert-butyl-[(3,5-dimethylphenyl)-oxomethyl]amino]-3-(4-chlorophenyl)urea[no description available]low00ureas
1-(3,4-dichlorophenyl)-3-(6-methylsulfonyl-1,3-benzothiazol-2-yl)urea[no description available]low00ureas
1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea[no description available]low00ureas
1-[1-methyl-2-(1-pyrrolidinylmethyl)-5-benzimidazolyl]-3-phenylurea[no description available]low00ureas
1-[2-(difluoromethoxy)-4-methylphenyl]-3-(2,4-difluorophenyl)urea[no description available]low00ureas
1-(2-fluorophenyl)-3-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea[no description available]low00ureas
3-amino-N-(4-methylphenyl)-5-(methylthio)-1,2,4-triazole-4-carboxamide[no description available]low00ureas
1-(4-chlorophenyl)-3-[5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-yl]urea[no description available]low00ureas
1-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-3-butyl-1-ethylurea[no description available]low00pyrimidone;
ureas
1-(4-bromo-2-fluorophenyl)-3-(3-chlorophenyl)urea[no description available]low00ureas
1-(2,5-dimethoxyphenyl)-3-[2-(trifluoromethyl)-1,3-benzodioxol-2-yl]urea[no description available]low00ureas
1-(4-bromophenyl)-3-[2-(2-methoxyphenoxy)ethyl]urea[no description available]low00ureas
thiourea[no description available]low00one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
1-(2,4-difluorophenyl)-3-[(5-methyl-3-phenyl-4-isoxazolyl)methyl]urea[no description available]low00ureas
4-benzyl-N-(3,5-dichlorophenyl)-1,4-diazepane-1-carboxamide[no description available]low00ureas
N1-(4-chlorophenyl)-3-(1H-pyrrol-1-ylmethyl)piperidine-1-carboxamide[no description available]low00ureas
1-(4-fluorophenyl)-3-[2-methyl-5-(1-piperidinylsulfonyl)-3-furanyl]urea[no description available]low00ureas
6-methyl-2-[[(4-methylanilino)-oxomethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester[no description available]low00ureas
1-[2-(4-chlorophenyl)sulfonylethyl]-1-ethyl-3-phenylurea[no description available]low00ureas
1-(3-chloro-4-propan-2-ylsulfonyl-2-thiophenyl)-3-(3-nitrophenyl)urea[no description available]low00ureas
1-(5-tert-butyl-2-methyl-3-pyrazolyl)-3-(3,5-dichlorophenyl)urea[no description available]low00ureas
1-(3,5-dichlorophenyl)-3-[2-(2-furanylmethylthio)ethyl]urea[no description available]low00ureas
3-methyl-4,7-bis(methylsulfonyl)-3a,5,6,7a-tetrahydro-1H-imidazo[4,5-b]pyrazin-2-one[no description available]low00imidazopyrazine;
sulfonamide;
ureas
1-[2-[[4,6-bis(1-piperidinyl)-1,3,5-triazin-2-yl]oxy]ethyl]-3-phenylurea[no description available]low00ureas
1-[2-[[4,6-bis(4-morpholinyl)-1,3,5-triazin-2-yl]oxy]ethyl]-3-phenylurea[no description available]low00ureas
1-(1,3-benzodioxol-5-yl)-3-(5-tert-butyl-2-methoxyphenyl)urea[no description available]low00ureas
1-[4-(4-morpholinyl)-2,1,3-benzoxadiazol-7-yl]-3-(4-nitrophenyl)urea[no description available]low00ureas
1-(3,5-dimethylphenyl)-3-(9-prop-2-enyl-9-azabicyclo[3.3.1]nonan-3-yl)urea[no description available]low00ureas
4-[butan-2-yl-[(3,4-dichloroanilino)-oxomethyl]amino]-1-piperidinecarboxylic acid ethyl ester[no description available]low00ureas
1-(2,6-dimethylphenyl)-3-thiophen-2-ylurea[no description available]low00ureas
1-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-3-thiophen-2-ylurea[no description available]low00ureas
N-(3,4-dimethylphenyl)-3-[(4-fluorophenyl)methyl]-1,3-diazinane-1-carboxamide[no description available]low00ureas
N-(4-fluorophenyl)-6-methyl-1-propyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxamide[no description available]low00ureas
n-(1-methyl-5-indolyl)-n'-(3-methyl-5-isothiazolyl)urea[no description available]low001,2-thiazoles;
indoles;
ureas		receptor modulator;
serotonergic antagonist
gw 7647[no description available]low00aryl sulfide;
monocarboxylic acid;
ureas		PPARalpha agonist
1-(2,5-dimethoxyphenyl)-3-[5-(2-methyl-1-piperidinyl)-1,3,4-thiadiazol-2-yl]urea[no description available]low00ureas
1-(3-methoxyphenyl)-3-[5-(2-methyl-1-piperidinyl)-1,3,4-thiadiazol-2-yl]urea[no description available]low00ureas
1-(3,4-dichlorophenyl)-3-[1-(4-morpholinyl)-1-phenylpropan-2-yl]urea[no description available]low00ureas
n-carbamylglutamate[no description available]low00glutamic acid derivative;
ureas		human metabolite
1-(1,3-benzodioxol-5-yl)-3-(4-fluorophenyl)urea[no description available]low00ureas
1-[(4-chlorophenyl)methyl]-3-(3-fluorophenyl)-1-(3,3,3-trifluoro-2-hydroxypropyl)urea[no description available]low00ureas
1-(4-chlorophenyl)-3-[2-(2-furanylmethyl)cyclohexyl]urea[no description available]low00ureas
1-(2,4-dichlorophenyl)-3-[3-(1-imidazolyl)propyl]urea[no description available]low00ureas
1-(3,4-dichlorophenyl)-3-[diethoxyphosphoryl(phenyl)methyl]urea[no description available]low00ureas
1-(3-chloro-4-methoxyphenyl)-3-(2-fluorophenyl)urea[no description available]low00ureas
1-(3-chlorophenyl)-3-pyridin-4-ylurea[no description available]low00ureas
1-(2,4-difluorophenyl)-3-[4-(2-pyridinyl)-2-thiazolyl]urea[no description available]low00ureas
2-(Chloroacetyl)-N,2-diphenylhydrazinecarboxamide[no description available]low00ureasanticoronaviral agent
1-(3,4-dichlorophenyl)-3-(1,3,5-trimethyl-4-pyrazolyl)urea[no description available]low00ureas
1-[(4-methylphenyl)methyl]-1,3-diazinan-2-one[no description available]low00pyrimidone;
ureas
l796778[no description available]low00benzenes;
C-nitro compound;
L-lysine derivative;
L-phenylalanine derivative;
methyl ester;
oligopeptide;
secondary carboxamide;
ureas		somatostatin receptor agonist
pd 166866[no description available]low00biaryl;
dimethoxybenzene;
primary arylamine;
pyridopyrimidine;
ureas		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
bw b70c[no description available]low00aromatic ether;
hydroxamic acid;
organofluorine compound;
ureas		EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
3-[[(3-methoxyanilino)-oxomethyl]amino]benzoic acid[no description available]low00ureas
1-(3-methoxyphenyl)-3-[2-(methylthio)phenyl]urea[no description available]low00ureas
4-[[(2,4-difluoroanilino)-oxomethyl]amino]benzoic acid[no description available]low00ureas
1-(2-methoxy-5-methylphenyl)-3-pyridin-4-ylurea[no description available]low00ureas
1-(3,4-dimethoxyphenyl)-3-(2-fluoro-5-methylphenyl)urea[no description available]low00ureas
1-butan-2-yl-3-(4-ethoxyphenyl)urea[no description available]low00ureas
avibactam[no description available]low00azabicycloalkane;
hydroxylamine O-sulfonic acid;
monocarboxylic acid amide;
ureas		antibacterial drug;
antimicrobial agent;
EC 3.5.2.6 (beta-lactamase) inhibitor
lonafarnib[no description available]low00benzocycloheptapyridine;
heteroarylpiperidine;
N-acylpiperidine;
organobromine compound;
organochlorine compound;
ureas
ly2090314[no description available]low00diazepinoindole;
imidazopyridine;
maleimides;
monofluorobenzenes;
piperidinecarboxamide;
ureas		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
Wnt signalling activator
pimavanserin[no description available]low00aromatic ether;
monofluorobenzenes;
piperidines;
tertiary amino compound;
ureas		5-hydroxytryptamine 2A receptor inverse agonist;
antipsychotic agent;
serotonergic antagonist
bx795[no description available]low00ureas
ns3694[no description available]low00ureas
n-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide[no description available]low00tripeptide;
ureas		antiviral drug;
hepatitis C protease inhibitor;
peptidomimetic
cyt997[no description available]low00ureas
pd 0348292[no description available]low00monochlorobenzenes;
monofluorobenzenes;
pyridone;
pyrrolidines;
secondary carboxamide;
ureas		anticoagulant;
EC 3.4.21.6 (coagulation factor Xa) inhibitor;
serine protease inhibitor
omecamtiv mecarbil[no description available]low00ureas
N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide[no description available]low00ureas
narlaprevir[no description available]low00azabicyclohexane;
cyclopropanes;
pyrrolidinecarboxamide;
secondary carboxamide;
sulfone;
tertiary carboxamide;
ureas		anticoronaviral agent;
antiviral drug;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
hepatitis C protease inhibitor
ly2603618[no description available]low00ureas
dactolisib[no description available]low00imidazoquinoline;
nitrile;
quinolines;
ring assembly;
ureas		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
mTOR inhibitor
1-(2,3-dihydro-1H-inden-5-yl)-3-(2-ethoxyphenyl)urea[no description available]low00ureas
1-(2,3-dichlorophenyl)-3-pyridin-4-ylurea[no description available]low00ureas
sns 314[no description available]low00ureas
cobicistat[no description available]low001,3-thiazoles;
carbamate ester;
monocarboxylic acid amide;
morpholines;
ureas		P450 inhibitor
wye 125132[no description available]low00ureas
3-cyclohexyl-1-[[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-8-[[(4-methoxyanilino)-oxomethyl]amino]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methylurea[no description available]low00ureas
1-[[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-8-[[oxo-(propan-2-ylamino)methyl]amino]-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-phenylurea[no description available]low00ureas
1-[(2S,3R)-2-[[cyclohexylmethyl(methyl)amino]methyl]-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]-3-(4-methoxyphenyl)urea[no description available]low00ureas
N-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-2-[[[(4-methoxyanilino)-oxomethyl]-methylamino]methyl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]cyclohexanecarboxamide[no description available]low00ureas
1-[[(2R,3S)-8-[[(cyclohexylamino)-oxomethyl]amino]-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-[4-(trifluoromethyl)phenyl]urea[no description available]low00ureas
4,4,4-trifluoro-N-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-2-[[[(4-methoxyanilino)-oxomethyl]-methylamino]methyl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]butanamide[no description available]low00ureas
N-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-2-[[methyl-[oxo-[4-(trifluoromethyl)anilino]methyl]amino]methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]-2-phenylacetamide[no description available]low00ureas
1-[[(2S,3S)-10-[[(cyclohexylamino)-oxomethyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-3-(4-methoxyphenyl)-1-methylurea[no description available]low00ureas
1-(4-fluorophenyl)-3-[(2R,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-2-[[methyl-(phenylmethyl)amino]methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]urea[no description available]low00ureas
1-[[(2S,3S)-10-[[(cyclohexylamino)-oxomethyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-[4-(trifluoromethyl)phenyl]urea[no description available]low00ureas
1-[[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-10-[[oxo-(propan-2-ylamino)methyl]amino]-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-phenylurea[no description available]low00ureas
N-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-2-[[methyl-[oxo-[4-(trifluoromethyl)anilino]methyl]amino]methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]-4-pyridinecarboxamide[no description available]low00ureas
1-[[(2S,3R)-10-[[(cyclohexylamino)-oxomethyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-[4-(trifluoromethyl)phenyl]urea[no description available]low00ureas
N-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-2-[[methyl-[oxo-[4-(trifluoromethyl)anilino]methyl]amino]methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]cyclohexanecarboxamide[no description available]low00ureas
1-[[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-10-[[oxo-[4-(trifluoromethyl)anilino]methyl]amino]-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-phenylurea[no description available]low00ureas
1-[[(2S,3S)-10-(dimethylamino)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-[4-(trifluoromethyl)phenyl]urea[no description available]low00ureas
1-[[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-10-[[(4-methoxyanilino)-oxomethyl]amino]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methyl-3-propan-2-ylurea[no description available]low00ureas
1-[[(2R,3R)-5-[(2R)-1-hydroxypropan-2-yl]-9-[[(4-methoxyanilino)-oxomethyl]amino]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-2-yl]methyl]-1-methyl-3-phenylurea[no description available]low00ureas
N-[(2S,3S)-5-[(2S)-1-hydroxypropan-2-yl]-2-[[[(4-methoxyanilino)-oxomethyl]-methylamino]methyl]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]cyclopropanecarboxamide[no description available]low00ureas
CAY10626[no description available]low00ureas
1-[4-fluoro-3-(trifluoromethyl)phenyl]-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea[no description available]low00ureas
1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea[no description available]low00ureas
fenobam[no description available]low00ureas
ConditionIndicatedRelationship StrengthStudiesTrials
Inflammation0low10
Innate Inflammatory Response0low10