Page last updated: 2024-12-07
3,5-dimethoxytoluene
Description
3,5-Dimethoxytoluene, also known as 3,5-dimethyl anisole, is a white crystalline solid. It is a derivative of toluene with methoxy groups at the 3 and 5 positions. It is a common starting material in organic synthesis, particularly for the production of pharmaceuticals and agrochemicals. It can be synthesized through various methods, including methylation of 3,5-dihydroxytoluene or direct methylation of toluene with methanol in the presence of a suitable catalyst. Research on 3,5-dimethoxytoluene focuses on its potential applications in various fields, such as the synthesis of novel drugs, the development of new catalysts, and the study of its biological activity. For example, it is a precursor for the synthesis of the antipsychotic drug haloperidol and the antidepressant drug amitriptyline. Further research is ongoing to explore its potential in other areas like biofuel production and materials science.'
3,5-dimethoxytoluene: a component of rose fragrance; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
3,5-dimethoxytoluene : A member of the class of toluenes that is toluene in which the hydrogens at positions 3 and 5 have been replaced by methoxy groups. It is the major scent compound of many rose varieties. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 77844 |
| CHEBI ID | 141217 |
| SCHEMBL ID | 12501 |
| MeSH ID | M0438556 |
Synonyms (40)
| Synonym |
|---|
| 1,3-dimethoxy-5-methyl-benzene |
| nsc 72352 |
| einecs 224-048-9 |
| ai3-21137 |
| toluene, 3,5-dimethoxy- |
| 4179-19-5 |
| 3,5-dimethoxytoluene |
| nsc72352 |
| nsc-72352 |
| benzene,3-dimethoxy-5-methyl- |
| 5-methylresorcinol dimethyl ether |
| orcinol dimethyl ether |
| 1,3-dimethoxy-5-methylbenzene |
| benzene, 1,3-dimethoxy-5-methyl- |
| inchi=1/c9h12o2/c1-7-4-8(10-2)6-9(5-7)11-3/h4-6h,1-3h |
| 3,5-dimethoxytoluene, 98% |
| 3,5-dimethoxy toluene |
| D2526 |
| 1,5-dimethoxy-3-methylbenzene |
| CHEBI:141217 |
| 5-methyl-1,3-dimethoxybenzene |
| 1-methyl-3,5-dimethoxybenzene |
| A825658 |
| AKOS006222974 |
| FT-0614651 |
| SCHEMBL12501 |
| FS-1194 |
| 2,4-dimethoxy-6-methylbenzene |
| DTXSID8063339 |
| J-640285 |
| W-106295 |
| mfcd00015435 |
| J-800284 |
| SY049574 |
| AMY17947 |
| 1,3-dimethoxy-5-methylbenzene pound>>orcinol dimethyl ether pound>>5-methylresorcinol dimethyl ether |
| BCP30604 |
| 3,5-dimethoxy-toluene |
| CS-W010951 |
| EN300-103512 |
Roles (2)
| Role | Description |
|---|
| fragrance | A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (2)
| Class | Description |
|---|
| toluenes | Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group. |
| methoxybenzenes | Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 24.00
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 24.00 (24.57) | | Research Supply Index | 2.08 (2.92) | | Research Growth Index | 4.44 (4.65) | | Search Engine Demand Index | 23.28 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (85.71%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |