Page last updated: 2024-12-07

3,5-dimethoxytoluene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,5-Dimethoxytoluene, also known as 3,5-dimethyl anisole, is a white crystalline solid. It is a derivative of toluene with methoxy groups at the 3 and 5 positions. It is a common starting material in organic synthesis, particularly for the production of pharmaceuticals and agrochemicals. It can be synthesized through various methods, including methylation of 3,5-dihydroxytoluene or direct methylation of toluene with methanol in the presence of a suitable catalyst. Research on 3,5-dimethoxytoluene focuses on its potential applications in various fields, such as the synthesis of novel drugs, the development of new catalysts, and the study of its biological activity. For example, it is a precursor for the synthesis of the antipsychotic drug haloperidol and the antidepressant drug amitriptyline. Further research is ongoing to explore its potential in other areas like biofuel production and materials science.'

3,5-dimethoxytoluene: a component of rose fragrance; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

3,5-dimethoxytoluene : A member of the class of toluenes that is toluene in which the hydrogens at positions 3 and 5 have been replaced by methoxy groups. It is the major scent compound of many rose varieties. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID77844
CHEBI ID141217
SCHEMBL ID12501
MeSH IDM0438556

Synonyms (40)

Synonym
1,3-dimethoxy-5-methyl-benzene
nsc 72352
einecs 224-048-9
ai3-21137
toluene, 3,5-dimethoxy-
4179-19-5
3,5-dimethoxytoluene
nsc72352
nsc-72352
benzene,3-dimethoxy-5-methyl-
5-methylresorcinol dimethyl ether
orcinol dimethyl ether
1,3-dimethoxy-5-methylbenzene
benzene, 1,3-dimethoxy-5-methyl-
inchi=1/c9h12o2/c1-7-4-8(10-2)6-9(5-7)11-3/h4-6h,1-3h
3,5-dimethoxytoluene, 98%
3,5-dimethoxy toluene
D2526
1,5-dimethoxy-3-methylbenzene
CHEBI:141217
5-methyl-1,3-dimethoxybenzene
1-methyl-3,5-dimethoxybenzene
A825658
AKOS006222974
FT-0614651
SCHEMBL12501
FS-1194
2,4-dimethoxy-6-methylbenzene
DTXSID8063339
J-640285
W-106295
mfcd00015435
J-800284
SY049574
AMY17947
1,3-dimethoxy-5-methylbenzene pound>>orcinol dimethyl ether pound>>5-methylresorcinol dimethyl ether
BCP30604
3,5-dimethoxy-toluene
CS-W010951
EN300-103512
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
fragranceA substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
toluenesAny member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group.
methoxybenzenesAny aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
3,5-dimethoxytoluene biosynthesis46

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.00 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.44 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]