minquartynoic acid: isolated from Minquartia guianensis & Ochanostachys amentacea; a tetra-alkyne [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
minquartynoic acid : A straight-chain, C18 polyunsaturated fatty acid having four conjugated C#C bonds at positions 9, 11, 13 and 15 as well as an (S)-hydroxy group at position 17. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Ochanostachys | genus | [no description available] | Olacaceae | A small plant family of the order Santalales, subclass Rosidae, class Magnoliopsida.[MeSH] |
| Minquartia | genus | [no description available] | Olacaceae | A small plant family of the order Santalales, subclass Rosidae, class Magnoliopsida.[MeSH] |
| Minquartia guianensis | species | [no description available] | Olacaceae | A small plant family of the order Santalales, subclass Rosidae, class Magnoliopsida.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 183614 |
| CHEMBL ID | 487989 |
| CHEBI ID | 542606 |
| MeSH ID | M0376042 |
| Synonym |
|---|
| minquartynoic acid |
| CHEMBL487989 |
| minquartic acid |
| (17s)-17-hydroxyoctadeca-9,11,13,15-tetraynoic acid |
| (-)-minquartynoic acid |
| 123154-43-8 |
| CHEBI:542606 , |
| (s)-minquartynoic acid |
| (s)-17-hydroxy-9,11,13,15-octadecatetraynoic acid |
| 17-hydroxyoctadeca-9,11,13,15-tetraynoic acid |
| DTXSID90153872 |
| 17s-hydroxyoctadecatetra-9,11,13,15-ynoic acid |
| LMFA01050459 |
| Q27105168 |
| Role | Description |
|---|---|
| antimalarial | A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. |
| antineoplastic agent | A substance that inhibits or prevents the proliferation of neoplasms. |
| antiviral agent | A substance that destroys or inhibits replication of viruses. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| tetrayne | Any acetylenic compound containing four carbon-carbon triple bonds. |
| long-chain fatty acid | A fatty acid with a chain length ranging from C13 to C22. |
| acetylenic fatty acid | Any unsaturated fatty acid containing at least one triple bond in the carbon chain framework. |
| straight-chain fatty acid | Any fatty acid whose skeletal carbon atoms form an unbranched open chain. |
| hydroxy polyunsaturated fatty acid | Any polyunsaturated fatty acid carrying one or more hydroxy substituents. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID377552 | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Absolute configuration and antiprotozoal activity of minquartynoic acid. |
| AID356705 | Cytotoxicity against mouse M109 cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID377554 | Inhibition of phytohemagglutininin A-induced proliferation in human lymphocytes assessed as radiolabeled thymidine uptake | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Absolute configuration and antiprotozoal activity of minquartynoic acid. |
| AID356700 | Cytotoxicity against multidrug-resistant human KB cells in presence of vinblastine | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356706 | Cytotoxicity against mouse P388 cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356702 | Cytotoxicity against human LNCAP cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356697 | Cytotoxicity against human Lu1 cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356698 | Cytotoxicity against human Col2 cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356703 | Cytotoxicity against human SW626 cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356704 | Cytotoxicity against human SK-N-SH cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356699 | Cytotoxicity against human KB cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356701 | Cytotoxicity against multidrug-resistant human KB cells in absence of vinblastine | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID356696 | Cytotoxicity against human BC1 cells | 2001 | Journal of natural products, Feb, Volume: 64, Issue:2 | Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea. |
| AID377553 | Antileishmanial activity against Leishmania major promastigotes after 20 hrs | 2000 | Journal of natural products, Sep, Volume: 63, Issue:9 | Absolute configuration and antiprotozoal activity of minquartynoic acid. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.99) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||