epsilon-N-methyllysine: RN given refers to (L-Lys)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
N(6)-methyllysine : A lysine derivative that is lysine in which one of the hydrogens attached to N(6) is substituted by a methyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
N(6)-methyl-L-lysine : An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by a methyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 164795 |
| CHEBI ID | 17604 |
| SCHEMBL ID | 64149 |
| MeSH ID | M0046580 |
| Synonym |
|---|
| (s)-2-amino-6-methylaminohexanoic acid |
| epsilon-n-methyllysine |
| n(epsilon)-methyl-l-lysine |
| CHEBI:17604 |
| n-methyl-l-lysine |
| epsilon-methyllysine |
| 1188-07-4 |
| n(6)-methyllysine |
| n(zeta)-methyllysine |
| n-epsilon-methyllysine |
| n(6)-methyl-l-lysine |
| melys |
| (2s)-2-amino-6-(methylamino)hexanoic acid |
| n-methyl-lysine |
| mlz , |
| n6-methyl-l-lysine , |
| C02728 |
| DB01714 |
| 1P0Y |
| unii-fcr6t2iyvu |
| l-lysine, n6-methyl- |
| fcr6t2iyvu , |
| SCHEMBL64149 |
| PQNASZJZHFPQLE-LURJTMIESA-N |
| DTXSID70152242 |
| n6-methyllysine |
| .epsilon.-methyl-l-lysine |
| .epsilon.-n-methyl-l-lysine |
| .epsilon.-methyllysine |
| (2s)-2-amino-6-(methylamino)hexanoate |
| (s)-2-amino-6-methylaminohexanoate |
| n-epsilon-methyl-l-lysine |
| n~6~-methyl-l-lysine |
| Q3334174 |
| n6-methyl-lysine; lc-tdda; ce10 |
| (2s)-2-amino-6-methylamino-hexanoic acid |
| Class | Description |
|---|---|
| L-lysine derivative | A proteinogenic amino acid derivative resulting from reaction of L-lysine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-lysine by a heteroatom. |
| non-proteinogenic L-alpha-amino acid | Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast | Pisum sativum (garden pea) | Ki | 100,800.0000 | 36,600.0000 | 68,700.0000 | 100,800.0000 | AID977610 |
| Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast | Pisum sativum (garden pea) | Ki | 100,800.0000 | 36,600.0000 | 68,700.0000 | 100,800.0000 | AID977610 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2003 | Nature structural biology, Jul, Volume: 10, Issue:7 | Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 10 (37.04) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 27 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| Bioavailability of some lysine derivatives in mice. The Journal of nutrition, Volume: 111, Issue: 8 | 1981 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |