Page last updated: 2024-10-24

proteasome regulatory particle binding

Definition

Target type: molecularfunction

Binding to a proteasome regulatory particle. [GOC:TermGenie, PMID:16096059]

Proteasome regulatory particle binding is a molecular function that describes the interaction of proteins with the regulatory particle (RP) of the proteasome. The RP is a multi-subunit complex that recognizes and binds to ubiquitinated proteins, marking them for degradation by the proteasome core particle.

The RP has two major sub-complexes: the 19S regulatory particle and the 11S regulatory particle.

* The 19S RP is composed of 19 subunits that can be broadly categorized into two functional modules: the lid and the base. The lid module functions in the recognition and unfolding of ubiquitinated proteins, while the base module acts as a gatekeeper for the proteasome core particle.

* The 11S RP, also known as PA28, functions in the removal of short-lived proteins that are not necessarily ubiquitinated.

The binding of proteins to the RP is essential for the proper functioning of the proteasome. The RP acts as a gatekeeper, controlling access to the proteasome core particle. The RP also plays a role in unfolding and translocating ubiquitinated proteins into the proteasome core particle for degradation.

In summary, the molecular function of proteasome regulatory particle binding involves the recognition, binding, unfolding, and translocation of proteins to the proteasome core particle for degradation.'
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Proteins (1)

ProteinDefinitionTaxonomy
Ubiquitin-like domain-containing CTD phosphatase 1A ubiquitin-like domain-containing CTD phosphatase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8WVY7]Homo sapiens (human)

Compounds (1)

CompoundDefinitionClassesRoles
salicylic acidScalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite