calcidiol binding
Definition
Target type: molecularfunction
Binding to calcidiol. [GOC:bf, GOC:TermGenie, PMID:11799400]
Calcidiol, also known as 25-hydroxyvitamin D3, is a precursor to the active form of vitamin D, calcitriol. It binds to the vitamin D binding protein (DBP) in the bloodstream, which acts as a carrier protein, ensuring the stable delivery of calcidiol to target tissues. Calcidiol binding to DBP is a crucial step in the vitamin D metabolic pathway. The binding occurs through a specific and high-affinity interaction, mediated by the hydrophobic interactions between the steroid ring of calcidiol and the hydrophobic pocket of DBP. This interaction protects calcidiol from degradation and facilitates its transport to the liver, where it is further metabolized to calcitriol. The calcidiol-DBP complex also plays a role in regulating the levels of free calcidiol in circulation, contributing to the overall homeostasis of vitamin D. While DBP is the primary carrier protein for calcidiol, other proteins like albumin can also bind calcidiol to a lesser extent. Overall, the binding of calcidiol to DBP is essential for its transport, protection, and regulation, enabling its effective delivery to target tissues for subsequent activation and function.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Vitamin D-binding protein | A vitamin D-binding protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P02774] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| calcitriol | dihydroxy-vitamin D3: as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes | D3 vitamins; hydroxycalciol; triol | antineoplastic agent; antipsoriatic; bone density conservation agent; calcium channel agonist; calcium channel modulator; hormone; human metabolite; immunomodulator; metabolite; mouse metabolite; nutraceutical |