Target type: molecularfunction
The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way. [PMID:27664236]
Ubiquitin ligase complex scaffold activity is a molecular function that involves the assembly and organization of ubiquitin ligase (E3) complexes. These complexes are essential for the ubiquitination process, which involves the covalent attachment of ubiquitin, a small protein, to target proteins. This process plays a crucial role in regulating a wide range of cellular processes, including protein degradation, signal transduction, DNA repair, and immune responses.
Ubiquitin ligase complex scaffolds act as platforms that bring together multiple components of the ubiquitination machinery, including E3 ligases, E2 ubiquitin-conjugating enzymes, and target proteins. By bringing these components into close proximity, scaffolds facilitate the transfer of ubiquitin from E2 enzymes to target proteins by E3 ligases.
Scaffold proteins can modulate the activity of ubiquitin ligase complexes in several ways. They can:
* **Recruit specific E2 and E3 enzymes** to the complex, determining the substrate specificity and ubiquitination outcome.
* **Provide a platform for the assembly of multi-protein complexes**, allowing for the coordinated regulation of multiple signaling pathways.
* **Act as allosteric regulators**, modulating the activity of E3 ligases by interacting with their active sites or by altering their conformation.
The assembly and regulation of ubiquitin ligase complex scaffolds are critical for maintaining cellular homeostasis. Dysregulation of these scaffolds can lead to various diseases, including cancer, neurodegenerative disorders, and immune system dysfunction.
In summary, ubiquitin ligase complex scaffold activity is a crucial molecular function that governs the assembly, organization, and regulation of ubiquitination complexes. These complexes are essential for a wide range of cellular processes, and their dysregulation can contribute to various diseases.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| DNA damage-binding protein 1 | A DNA damage-binding protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16531] | Homo sapiens (human) |
| Cullin-4A | A cullin-4A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13619] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| thalidomide | 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group. thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide. Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. | phthalimides; piperidones | |
| pomalidomide | 3-aminophthalimidoglutarimide: structure in first source | aromatic amine; dicarboximide; isoindoles; piperidones | angiogenesis inhibitor; antineoplastic agent; immunomodulator |
| lenalidomide | aromatic amine; dicarboximide; isoindoles; piperidones | angiogenesis inhibitor; antineoplastic agent; immunomodulator | |
| 4-pyridin-4-yl-2-sulfanylidene-5,6,7,8-tetrahydro-1H-quinoline-3-carbonitrile | bipyridines | ||
| jq1 compound | carboxylic ester; organochlorine compound; tert-butyl ester; thienotriazolodiazepine | angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; bromodomain-containing protein 4 inhibitor; cardioprotective agent; ferroptosis inducer | |
| MZ1 | organic molecular entity |