cyclic-GMP-AMP transmembrane transporter activity

Definition

Target type: molecularfunction

Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other. [PMID:31126740]

Cyclic-GMP-AMP (cGAMP) transmembrane transporter activity is a crucial molecular function involved in the innate immune response. cGAMP, a second messenger produced by the enzyme cGAS upon detection of foreign DNA, plays a critical role in activating the STING pathway. This pathway ultimately triggers the production of type I interferons (IFNs), potent antiviral cytokines.

cGAMP transmembrane transporters, also known as cGAMP importers, facilitate the transport of cGAMP across cellular membranes. This process is essential for the activation of STING in the cytoplasm, where the receptor is localized.

The precise mechanism of cGAMP transport remains under investigation, but it likely involves a facilitated diffusion process driven by the concentration gradient of cGAMP. The transporter protein likely interacts with cGAMP through specific binding sites, facilitating its movement across the membrane.

Overall, cGAMP transmembrane transporter activity is a vital component of the innate immune system. It enables the efficient transfer of cGAMP from the cytoplasm to the STING receptor, thereby triggering the activation of the antiviral signaling pathway. This function plays a critical role in the host's defense against viral infections.'
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Proteins (1)

Compounds (4)