folic acid:proton symporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid. [PMID:24745983]

Folic acid:proton symporter activity is a transmembrane transport process that involves the simultaneous movement of folic acid and protons across a cell membrane. This process is driven by the proton motive force, which is the electrochemical gradient of protons across the membrane. The folic acid:proton symporter protein is responsible for facilitating the movement of these molecules. This activity is essential for the uptake of folate into cells, where folate is required for a variety of metabolic processes, including DNA synthesis and repair. The symporter protein binds to both folic acid and protons, and the binding of one molecule facilitates the binding of the other. This coupling of binding events allows for the simultaneous movement of both molecules across the membrane. The folic acid:proton symporter is a highly specific protein that only transports folic acid and protons. This specificity is crucial for maintaining the appropriate intracellular levels of folate, which are essential for normal cell function.'
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Proteins (1)

Compounds (4)