ubiquitin-modified protein reader activity

Definition

Target type: molecularfunction

A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. [PMID:26060076]

Ubiquitin-modified protein reader activity refers to the ability of a protein to recognize and bind to ubiquitin modifications on other proteins. Ubiquitination is a reversible post-translational modification where a small protein called ubiquitin is attached to a target protein. Ubiquitin modification can have a variety of effects on target proteins, including altering their stability, localization, and activity.

Ubiquitin-modified protein reader domains often bind to specific ubiquitin linkages, which are formed by the covalent attachment of ubiquitin to lysine residues on target proteins. These domains can recognize different ubiquitin linkages, such as mono-ubiquitination, poly-ubiquitination, and multi-monoubiquitination.

Ubiquitin-modified protein readers play crucial roles in various cellular processes, including:

* **Protein degradation:** Ubiquitin-modified protein readers can bind to polyubiquitinated proteins, targeting them for degradation by the proteasome.
* **Signal transduction:** Some ubiquitin-modified protein readers can activate or inhibit downstream signaling pathways by interacting with ubiquitinated signaling proteins.
* **DNA repair:** Ubiquitin-modified protein readers can participate in DNA damage repair pathways by recognizing and binding to ubiquitinated DNA repair proteins.
* **Immune response:** Ubiquitin-modified protein readers can regulate immune responses by interacting with ubiquitinated immune receptors and signaling molecules.

These readers function as critical regulators of protein fate and cellular function, ensuring proper cellular homeostasis and response to various stimuli.'
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Proteins (1)

Compounds (6)