Page last updated: 2024-10-24

glutathione-dependent sulfide quinone oxidoreductase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: a quinone + glutathione + H+ + hydrogen sulfide = a quinol + S-sulfanylglutathione. [RHEA:55156]

Glutathione-dependent sulfide quinone oxidoreductase activity is a crucial enzyme activity involved in the detoxification of a wide range of substrates, including quinones, hydroquinones, and other reactive electrophiles. It catalyzes the reduction of quinones and other electrophilic compounds using glutathione as a reducing agent. This process is critical for protecting cells from oxidative stress and damage caused by reactive oxygen species (ROS). The reaction mechanism typically involves the transfer of electrons from glutathione to the substrate via a disulfide bond formed between the enzyme and glutathione. The enzyme then undergoes a conformational change, bringing the substrate and the reduced glutathione molecule into close proximity, facilitating electron transfer. This results in the reduction of the substrate and the oxidation of glutathione. The oxidized glutathione is then recycled back to its reduced form by glutathione reductase, utilizing NADPH as an electron donor. The overall reaction cycle serves to detoxify harmful compounds and maintain cellular redox homeostasis. This activity plays a significant role in various cellular processes, including antioxidant defense, signal transduction, and drug metabolism.'
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Proteins (1)

ProteinDefinitionTaxonomy
Sulfide:quinone oxidoreductase, mitochondrialA sulfide:quinone oxidoreductase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6N5]Homo sapiens (human)

Compounds (1)

CompoundDefinitionClassesRoles
carmofurorganohalogen compound;
pyrimidines