S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity

Definition

Target type: molecularfunction

Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+. [RHEA:19981]

S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity catalyzes the oxidation of S-(hydroxymethyl)glutathione to formaldehyde and glutathione. This reaction is important in the detoxification of formaldehyde, a toxic compound that can be produced as a byproduct of various metabolic processes. The enzyme uses NADP+ as a cofactor and requires the presence of both S-(hydroxymethyl)glutathione and NADP+ for optimal activity. The reaction mechanism involves the transfer of two electrons from S-(hydroxymethyl)glutathione to NADP+, resulting in the formation of formaldehyde, glutathione, and NADPH. S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity is found in a wide range of organisms, including bacteria, plants, and animals. In humans, the enzyme is primarily located in the liver, where it plays a key role in the detoxification of formaldehyde. Deficiencies in S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity can lead to the accumulation of formaldehyde in the body, which can cause various health problems.'
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Proteins (1)

Compounds (3)