histone succinyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone. [PMID:29211711]

Histone succinyltransferase activity is a crucial enzymatic process that plays a vital role in regulating gene expression and chromatin structure. Succinyltransferases, also known as succinyl-CoA:histone succinyltransferases, catalyze the transfer of a succinyl group from succinyl-CoA to lysine residues within histone proteins. This modification, known as histone succinylation, alters the electrostatic properties of histone tails, influencing their interactions with DNA and other chromatin-associated proteins.

Histone succinylation has been shown to impact a wide range of cellular processes, including:

* **Transcriptional regulation:** Histone succinylation can affect gene expression by modifying the accessibility of DNA to transcription factors. Succinylation at specific lysine residues may promote or inhibit gene transcription depending on the context and the specific histone protein involved.
* **Chromatin structure:** Histone succinylation can influence the organization and compaction of chromatin, which in turn regulates DNA replication, repair, and recombination. Succinylation can affect the formation of higher-order chromatin structures and the recruitment of specific chromatin-remodeling complexes.
* **Cellular signaling:** Histone succinylation has been implicated in cellular signaling pathways, potentially modulating the responses to environmental cues or developmental signals.

The molecular mechanisms underlying histone succinylation are complex and involve interactions with other histone modifications, enzymatic activity, and protein-protein interactions. Further research is ongoing to elucidate the precise roles of histone succinylation in different cellular contexts and its implications for human health and disease.'
"

Proteins (1)

Compounds (2)