Target type: molecularfunction
Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. [GOC:pz, PMID:1676842, PMID:9139674]
Leukotriene C4 gamma-glutamyl transferase activity is a crucial enzyme involved in the biosynthesis of leukotriene D4 (LTD4), a potent bronchoconstrictor and inflammatory mediator. This enzyme catalyzes the transfer of a gamma-glutamyl residue from glutathione to leukotriene C4 (LTC4), resulting in the formation of LTD4. The reaction involves the formation of a covalent intermediate between the enzyme and LTC4, followed by the transfer of the gamma-glutamyl moiety from glutathione to the cysteinyl residue of LTC4. This enzymatic activity is critical for the development of the inflammatory cascade associated with allergic and asthmatic responses. Specifically, LTD4 contributes to bronchoconstriction, mucus secretion, vascular permeability, and leukocyte chemotaxis, all contributing to the symptoms of asthma and other inflammatory disorders.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Glutathione hydrolase 1 proenzyme | A glutathione hydrolase 1 proenzyme that is encoded in the genome of human. [PRO:CNA, UniProtKB:P19440] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| aspirin | acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) | benzoic acids; phenyl acetates; salicylates | anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent |