Target type: molecularfunction
Catalysis of the reaction: 16-hydroxypalmitate + NADP = H+ + 16-oxo-palmitate + NADPH. [GOC:pz]
16-Hydroxypalmitate dehydrogenase activity is an enzyme-catalyzed reaction that specifically removes a hydrogen atom from the 16th carbon of palmitate, a saturated fatty acid with 16 carbon atoms, and oxidizes it to form 16-hydroxypalmitate. This reaction plays a crucial role in fatty acid metabolism, particularly in the biosynthesis of very long-chain fatty acids (VLCFAs).
Specifically, 16-hydroxypalmitate dehydrogenase is involved in the elongation of palmitate to produce VLCFAs, which are essential components of various cellular structures, including myelin sheaths, cell membranes, and lipids involved in signal transduction.
The enzymatic activity of 16-hydroxypalmitate dehydrogenase is dependent on the presence of a cofactor, such as NAD+ (nicotinamide adenine dinucleotide) or NADP+ (nicotinamide adenine dinucleotide phosphate). These cofactors act as electron acceptors, accepting the hydrogen atom removed from palmitate.
The overall reaction catalyzed by 16-hydroxypalmitate dehydrogenase can be summarized as follows:
Palmitate + NAD+ --u003e 16-Hydroxypalmitate + NADH + H+
This reaction is highly specific and requires the presence of a specific substrate, palmitate, and a cofactor, NAD+ or NADP+. The enzyme responsible for this activity is known as 16-hydroxypalmitate dehydrogenase and is a key component in the metabolic pathways involved in VLCFA biosynthesis.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Cytochrome P450 4A22 | A cytochrome P450 4A22 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q5TCH4] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tranylcypromine | (1R,2S)-tranylcypromine : A 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine. tranylcypromine : A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine). Tranylcypromine: A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) | 2-phenylcyclopropan-1-amine | |
| proadifen hydrochloride | |||
| pirlindole | pirlindole: RN given refers to parent cpd; synonym pyrazidol refers to mono-HCl; structure in Negwer, 5th ed, #2812 | carbazoles | |
| kaf156 | ganaplacide: antimalarial |