Page last updated: 2024-10-24

S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine. [EC:2.1.1.49, GOC:pz]

S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity is a type of methyltransferase activity that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to beta-alanine. This reaction is crucial for the biosynthesis of carnosine and anserine, two dipeptides found primarily in skeletal muscle. Carnosine and anserine play roles in buffering intracellular pH, protecting against oxidative stress, and enhancing muscle function. The methyltransferase activity involves the following steps: 1. The enzyme binds both SAM and beta-alanine. 2. SAM undergoes a conformational change, bringing its methyl group close to the beta-alanine. 3. The methyl group is transferred from SAM to the nitrogen atom of beta-alanine. 4. S-adenosyl-L-homocysteine (SAH) is released as a byproduct. This process is essential for the synthesis of carnosine and anserine, which contribute to various physiological processes within the body.'
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Proteins (1)

ProteinDefinitionTaxonomy
Indolethylamine N-methyltransferaseAn indolethylamine N-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95050]Homo sapiens (human)

Compounds (4)

CompoundDefinitionClassesRoles
sinefunginadenosines;
non-proteinogenic alpha-amino acid
antifungal agent;
antimicrobial agent
1,8-diazabicyclo(5.4.0)undec-7-ene
s-adenosylhomocysteineS-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine.

S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide
cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite
5'-methylthioadenosine5'-methylthioadenosine: structure

5'-S-methyl-5'-thioadenosine : Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.
thioadenosinealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite