S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine. [EC:2.1.1.49, GOC:pz]
S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity is a type of methyltransferase activity that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to beta-alanine. This reaction is crucial for the biosynthesis of carnosine and anserine, two dipeptides found primarily in skeletal muscle. Carnosine and anserine play roles in buffering intracellular pH, protecting against oxidative stress, and enhancing muscle function. The methyltransferase activity involves the following steps: 1. The enzyme binds both SAM and beta-alanine. 2. SAM undergoes a conformational change, bringing its methyl group close to the beta-alanine. 3. The methyl group is transferred from SAM to the nitrogen atom of beta-alanine. 4. S-adenosyl-L-homocysteine (SAH) is released as a byproduct. This process is essential for the synthesis of carnosine and anserine, which contribute to various physiological processes within the body.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Indolethylamine N-methyltransferase | An indolethylamine N-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95050] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| sinefungin | adenosines; non-proteinogenic alpha-amino acid | antifungal agent; antimicrobial agent | |
| 1,8-diazabicyclo(5.4.0)undec-7-ene | |||
| s-adenosylhomocysteine | S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine. S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. | adenosines; amino acid zwitterion; homocysteine derivative; homocysteines; organic sulfide | cofactor; EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor; EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor; epitope; fundamental metabolite |
| 5'-methylthioadenosine | 5'-methylthioadenosine: structure 5'-S-methyl-5'-thioadenosine : Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group. | thioadenosine | algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |