poly-ADP-D-ribose binding

Definition

Target type: molecularfunction

Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. [GOC:mah, GOC:sart, PMID:20088964]

Poly-ADP-ribose (PAR) binding is a molecular function that involves the recognition and interaction of proteins with PAR, a highly branched polymer of ADP-ribose units. PAR is synthesized by PAR polymerases (PARPs) and plays a crucial role in various cellular processes, including DNA repair, transcription, apoptosis, and inflammation. PAR binding proteins contain specific domains that bind to PAR, such as the PAR-binding zinc finger (PBZ) domain, the macro domain, and the WWE domain. These domains are characterized by their ability to recognize the unique structural features of PAR, such as its negatively charged phosphate groups and its branched structure. Upon binding to PAR, PAR binding proteins can act as scaffold proteins to recruit other proteins to sites of DNA damage or as signal transducers to initiate downstream signaling pathways. For example, PAR binding proteins involved in DNA repair, such as PARP1, can recruit other DNA repair factors to the site of damage to facilitate DNA repair. Other PAR binding proteins, such as the apoptotic protease-activating factor 1 (Apaf-1), can bind to PAR and initiate the caspase cascade, leading to apoptosis. Therefore, PAR binding is a crucial molecular function involved in a wide range of cellular processes and is essential for maintaining cellular homeostasis.'
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Proteins (1)

Compounds (14)