histone H3T3 kinase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: histone H3-threonine (position 3) + ATP = histone H3-phosphothreonine (position 3) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 3 of histone H3. [GOC:mah]

Histone H3T3 kinase activity refers to the enzymatic activity of transferring a phosphate group from ATP to the threonine residue at position 3 (T3) on the histone H3 protein. This phosphorylation event plays a crucial role in regulating chromatin structure and gene expression. Histone H3T3 phosphorylation is associated with a number of cellular processes, including:
* **Chromatin condensation:** Phosphorylation at T3 can contribute to the condensation of chromatin, which can suppress gene expression.
* **DNA replication:** Phosphorylation at T3 is involved in the recruitment of DNA replication factors and the initiation of DNA replication.
* **DNA repair:** Phosphorylation at T3 can be involved in the recruitment of DNA repair factors and the repair of damaged DNA.
* **Cell cycle regulation:** Phosphorylation at T3 is involved in the regulation of cell cycle progression.
* **Gene expression:** Phosphorylation at T3 can influence gene expression by altering the accessibility of DNA to transcription factors.
The specific role of H3T3 phosphorylation in these processes can vary depending on the cellular context and the specific kinases and phosphatases involved. For example, phosphorylation at T3 can be influenced by the activity of different kinases, such as the Aurora kinases, which are involved in cell cycle regulation, and the ATM kinase, which is involved in DNA repair. In addition to the above, H3T3 phosphorylation can also influence the binding of other proteins to chromatin, thus contributing to the overall regulation of gene expression and chromatin structure. Overall, H3T3 kinase activity is a dynamic and multifaceted process that plays a critical role in regulating a wide range of cellular processes.'
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Proteins (2)

Compounds (12)