histone H3T3 kinase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: histone H3-threonine (position 3) + ATP = histone H3-phosphothreonine (position 3) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 3 of histone H3. [GOC:mah]
Histone H3T3 kinase activity refers to the enzymatic activity of transferring a phosphate group from ATP to the threonine residue at position 3 (T3) on the histone H3 protein. This phosphorylation event plays a crucial role in regulating chromatin structure and gene expression. Histone H3T3 phosphorylation is associated with a number of cellular processes, including:
* **Chromatin condensation:** Phosphorylation at T3 can contribute to the condensation of chromatin, which can suppress gene expression.
* **DNA replication:** Phosphorylation at T3 is involved in the recruitment of DNA replication factors and the initiation of DNA replication.
* **DNA repair:** Phosphorylation at T3 can be involved in the recruitment of DNA repair factors and the repair of damaged DNA.
* **Cell cycle regulation:** Phosphorylation at T3 is involved in the regulation of cell cycle progression.
* **Gene expression:** Phosphorylation at T3 can influence gene expression by altering the accessibility of DNA to transcription factors.
The specific role of H3T3 phosphorylation in these processes can vary depending on the cellular context and the specific kinases and phosphatases involved. For example, phosphorylation at T3 can be influenced by the activity of different kinases, such as the Aurora kinases, which are involved in cell cycle regulation, and the ATM kinase, which is involved in DNA repair. In addition to the above, H3T3 phosphorylation can also influence the binding of other proteins to chromatin, thus contributing to the overall regulation of gene expression and chromatin structure. Overall, H3T3 kinase activity is a dynamic and multifaceted process that plays a critical role in regulating a wide range of cellular processes.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Serine/threonine-protein kinase VRK1 | A serine/threonine-protein kinase VRK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99986] | Homo sapiens (human) |
| Serine/threonine-protein kinase haspin | A serine/threonine-protein kinase haspin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TF76] | Homo sapiens (human) |
Compounds (12)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| ro 31-8220 | Ro 31-8220: a protein kinase C inhibitor | imidothiocarbamic ester; indoles; maleimides | EC 2.7.11.13 (protein kinase C) inhibitor |
| staurosporine | indolocarbazole alkaloid; organic heterooctacyclic compound | apoptosis inducer; bacterial metabolite; EC 2.7.11.13 (protein kinase C) inhibitor; geroprotector | |
| harmol | harmol: harmol is oxidized form of alkaloid harmolol; RN given refers to parent cpd; structure | harmala alkaloid | |
| adenosine-5'-carboxylic acid | purine nucleoside | ||
| cercosporamide | cercosporamide : A member of the class of dibenzofurans that is a potent broad spectrum antifungal agent isolated from the fungus Cercosporidium henningsii. cercosporamide: antineoplastic; RN refers to (S)-isomer | dibenzofurans; methyl ketone; monocarboxylic acid amide; polyphenol | antifungal agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; fungal metabolite; phytotoxin |
| harmine | harmine : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7. Harmine: Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920's. | harmala alkaloid | anti-HIV agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; metabolite |
| sgi 1776 | SGI 1776: a Pim kinase inhibitor; structure in first source | imidazoles | |
| bi d1870 | |||
| nms p937 | NMS P937: a polo-like kinase 1 inhibitor; structure in first source | ||
| nms-p118 | NMS-P118: a PARP-1 inhibitor; structure in first source | ||
| chr-6494 | |||
| nms-e973 | NMS-E973: structure in first source |