NuA4 histone acetyltransferase complex binding
Definition
Target type: molecularfunction
Binding to a NuA4 histone acetyltransferase complex. [PMID:15528408]
The NuA4 histone acetyltransferase (HAT) complex is a multi-protein complex that plays a crucial role in regulating gene expression by catalyzing the acetylation of lysine residues on histone proteins. This acetylation process is a key component of chromatin remodeling, which involves changes in the structure of chromatin, the complex of DNA and proteins that package DNA in the nucleus.
NuA4 HAT complex binding is a complex molecular function involving multiple steps and interactions:
1. **Recruitment:** NuA4 is recruited to specific DNA regions through interactions with DNA binding proteins, such as transcription factors, and other chromatin-associated proteins. These interactions are often mediated by specific domains or motifs present in NuA4 subunits.
2. **Chromatin Association:** Once recruited, NuA4 associates with nucleosomes, the basic repeating units of chromatin that consist of DNA wrapped around histone proteins. The association of NuA4 with nucleosomes is facilitated by its interaction with histone tails and other histone modifications.
3. **Acetylation Catalysis:** The catalytic subunit of NuA4, known as Tip60, possesses HAT activity and catalyzes the transfer of an acetyl group from acetyl-CoA to lysine residues on histone tails. Specifically, NuA4 primarily acetylates histones H4 and H2A at specific lysine residues, including H4K5, H4K8, H4K12, H4K16, and H2AK5.
4. **Chromatin Remodeling:** The acetylation of histone tails by NuA4 alters the electrostatic interactions between histones and DNA, leading to a more open and accessible chromatin structure. This chromatin remodeling process facilitates the recruitment of other factors involved in gene expression, such as transcription factors and RNA polymerase II, promoting gene transcription.
5. **Gene Expression Regulation:** The acetylation of histone tails by NuA4, by promoting chromatin remodeling and gene transcription, ultimately contributes to the regulation of gene expression. NuA4 is involved in the activation of a variety of genes, including those involved in cell cycle progression, DNA repair, and developmental processes.
Overall, the molecular function of NuA4 HAT complex binding is a complex process that involves multiple steps, from the initial recruitment of the complex to the final modulation of gene expression. The acetylation of histone tails by NuA4 is a crucial step in chromatin remodeling and plays a vital role in regulating gene expression in various cellular processes.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| MBT domain-containing protein 1 | An MBT domain-containing protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05BQ5] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| bifemelane | bifemelane: structure given in first source | diarylmethane | |
| chlorpheniramine | chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE. | monochlorobenzenes; pyridines; tertiary amino compound | anti-allergic agent; antidepressant; antipruritic drug; H1-receptor antagonist; histamine antagonist; serotonin uptake inhibitor |
| maprotiline | Maprotiline: A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use. | anthracenes | |
| oxybutynin | oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder. oxybutynin: RN given refers to parent cpd | acetylenic compound; carboxylic ester; racemate; tertiary alcohol; tertiary amino compound | antispasmodic drug; calcium channel blocker; local anaesthetic; muscarinic antagonist; muscle relaxant; parasympatholytic |
| (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone | aromatic carboxylic acid; pyridinemonocarboxylic acid | ||
| entecavir | benzamides; N-acylpiperidine |