Target type: molecularfunction
Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis. [GOC:dph, PMID:26277776]
Forked DNA-dependent helicase activity is a molecular function that involves the unwinding of DNA at replication forks. These forks are Y-shaped structures that form during DNA replication, where the two strands of the DNA double helix are separated to allow for the synthesis of new DNA strands. Helicases, enzymes that catalyze this process, use energy from ATP hydrolysis to break the hydrogen bonds between complementary base pairs, allowing the two strands to separate. Forked DNA-dependent helicases specifically target these replication forks and play a crucial role in DNA replication by ensuring that the DNA strands are unwound in a controlled and efficient manner. They also help to prevent the formation of secondary structures in the single-stranded DNA that could interfere with replication. In addition to DNA replication, forked DNA-dependent helicases are also involved in other processes, such as DNA repair and recombination.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Werner syndrome ATP-dependent helicase | A bifunctional 3-5 exonuclease/ATP-dependent helicase WRN that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14191] | Homo sapiens (human) |
| Bloom syndrome protein | A RecQ-like DNA helicase BLM that is encoded in the genome of human. [PRO:DNx, UniProtKB:P54132] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea | ureas | ||
| 1-[4-fluoro-3-(trifluoromethyl)phenyl]-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea | ureas |