Target type: molecularfunction
Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O . [MetaCyc:RXN-11003]
Tocotrienol omega-hydroxylase activity refers to the enzymatic catalysis of the hydroxylation reaction at the omega position of tocotrienols. Tocotrienols are a type of vitamin E that possess a unique isoprenoid side chain, which distinguishes them from tocopherols. This enzyme catalyzes the addition of a hydroxyl group (-OH) to the terminal carbon of the isoprenoid side chain, converting tocotrienol into its corresponding omega-hydroxy derivative. The reaction involves the incorporation of molecular oxygen (O2) and typically requires the presence of a cofactor, such as NADPH or NADH. This hydroxylation reaction is essential for the metabolism and detoxification of tocotrienols within the body. It has been shown to play a role in regulating the levels of tocotrienols in various tissues, including the liver and brain. The specific mechanism of tocotrienol omega-hydroxylase activity involves the formation of a reactive oxygen species intermediate, which then attacks the omega carbon of the tocotrienol molecule. This process results in the addition of a hydroxyl group and the formation of the omega-hydroxy derivative. The precise molecular details of this reaction, including the specific enzyme involved and its active site structure, are still being investigated. However, the overall function of tocotrienol omega-hydroxylase activity is to convert tocotrienols into their hydroxylated forms, which may have different biological activities and metabolic fates.'
"
| Protein | Definition | Taxonomy |
|---|---|---|
| Cytochrome P450 4F2 | A cytochrome P450 4F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78329] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 17-octadecynoic acid | octadec-17-ynoic acid : An acetylenic fatty acid that is octadecanoi acid (stearic acid) which has been doubly dehydrogenated at positions 17 and 18 to give the corresponding alkynoic acid. | acetylenic fatty acid; long-chain fatty acid; monounsaturated fatty acid; terminal acetylenic compound | EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitor; EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor; P450 inhibitor |
| ketoconazole | 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively. | dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine | |
| tranylcypromine | (1R,2S)-tranylcypromine : A 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine. tranylcypromine : A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine). Tranylcypromine: A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) | 2-phenylcyclopropan-1-amine | |
| proadifen hydrochloride | |||
| pirlindole | pirlindole: RN given refers to parent cpd; synonym pyrazidol refers to mono-HCl; structure in Negwer, 5th ed, #2812 | carbazoles | |
| kaf156 | ganaplacide: antimalarial |