Target type: molecularfunction
Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate. [EC:3.1.1.32]
1-acyl-2-lysophosphatidylserine acylhydrolase activity is a type of hydrolase that specifically cleaves the ester bond between the fatty acid at the sn-1 position of 1-acyl-2-lysophosphatidylserine, releasing a free fatty acid and lysophosphatidylserine. This enzyme plays a crucial role in the metabolism of phospholipids, particularly in the breakdown of lysophosphatidylserine, a product of phospholipase A2 activity. It is involved in the recycling of fatty acids and the generation of lysophospholipids, which serve as signaling molecules and precursors for the synthesis of other phospholipids. 1-acyl-2-lysophosphatidylserine acylhydrolase activity is also implicated in the regulation of membrane fluidity and cellular signaling pathways. Its specific action on 1-acyl-2-lysophosphatidylserine distinguishes it from other acylhydrolases that act on different phospholipid substrates.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Endothelial lipase | An endothelial lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5X9] | Homo sapiens (human) |
| Hepatic triacylglycerol lipase | A hepatic triacylglycerol lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11150] | Homo sapiens (human) |
| Lipoprotein lipase | A lipoprotein lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06858] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| nutlin 3 | stilbenoid | ||
| orlistat | orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity. | beta-lactone; carboxylic ester; formamides; L-leucine derivative | anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor |
| xen445 |