Target type: molecularfunction
Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid. [KEGG_REACTION:R04034]
Phosphatidylserine 1-acylhydrolase activity refers to the enzymatic hydrolysis of the ester bond at the sn-1 position of phosphatidylserine. This enzyme, also known as lysophosphatidylserine acylhydrolase, catalyzes the removal of a fatty acid from the sn-1 position of phosphatidylserine, generating lysophosphatidylserine and a free fatty acid. The reaction requires water as a substrate. This activity is essential for the breakdown of phosphatidylserine, a major phospholipid component of cell membranes, and plays a crucial role in various cellular processes, including membrane remodeling, lipid signaling, and the generation of bioactive lysophospholipids. Notably, phosphatidylserine 1-acylhydrolase activity can be regulated by various factors, including pH, calcium ions, and the presence of specific inhibitors. Its dysregulation has been linked to various diseases, highlighting its importance in maintaining cellular homeostasis.'
"
| Protein | Definition | Taxonomy |
|---|---|---|
| Endothelial lipase | An endothelial lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5X9] | Homo sapiens (human) |
| Hepatic triacylglycerol lipase | A hepatic triacylglycerol lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P11150] | Homo sapiens (human) |
| Lipoprotein lipase | A lipoprotein lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06858] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| nutlin 3 | stilbenoid | ||
| orlistat | orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity. | beta-lactone; carboxylic ester; formamides; L-leucine derivative | anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor |
| xen445 |